Joint inflammation is a common manifestation of systemic immune challenges, yet the anatomical basis for joint sensitivity remains unclear. Using whole-mount imaging of the synovium, we identify fenestrated capillaries localized to the lining–sublining interface of the lateral synovial compartment creating discrete permeable vascular niches. These capillaries permit entry of circulating inflammatory stimuli and are closely associated with specialized macrophage subsets and nociceptor neurons, forming a blood–joint barrier that coordinates immune defense and pain signaling.
開催日
-
2026/3/25
15:30-16:30
開催場所（方法）
CCIIがん免疫総合研究センター BMS棟1階ニトリホール（Zoomなし）
NITORI Hall on 1st floor, CCII-BMS Bld. (Onsite only)
詳細
講演者/Speaker: Dr. Tetsuo Hasegawa
Principal Investigator of Molecular Immunity Unit,
MRC Laboratory of Molecular Biology, University of Cambridge
タイトル/Title: “Fenestrated capillaries and the sentinel macrophage-nociceptor unit in joint immunity”
日時/Date & Time: March 25 (Wed) 15:30-16:30
会場/Venue: NITORI Hall on 1st floor, CCII-BMS Bld.
言語/Language: English
詳細/Details: https://www.ccii.med.kyoto-u.ac.jp/event/event_20568/
申し込み
不要
参加費
Free / 無料
お問い合わせ
京都大学 白眉センター／がん免疫総合研究センター（CCII） 特定准教授 佐藤 有紀
Yuki Sato, Associate Professor, Hakubi Center for Advanced Research / CCII, Kyoto University
e-mail: yukisato@kuhp.kyoto-u.ac.jp