The Basic Residue-Rich Sequence (BRS) is a conserved signaling motif widely present in immunoreceptors but remains poorly understood. By forming electrostatic networks with charged lipids and proteins near the membrane, BRS regulates phosphorylation, ubiquitination, condensation, and mechanotransduction. It also coordinates with tyrosine-based motifs to define immunoreceptor function. Evidence from animal and clinical studies shows that harnessing BRS signaling enhances T-cell persistence and sensitivity, unveiling a new avenue for designing next-generation immunotherapies.
開催日
-
2025/11/18
15：00-16：00
開催場所（方法）
BMS棟1階ニトリホール（Zoomなし）
詳細
Speaker: Dr. Chenqi Xu, Professor / Deputy Director, Shanghai Institute of Biochemistry and Cell Biology / Chinese Academy of Sciences
Title: "Uncovering the Basic Residue-Rich Sequence: from immunoreceptor signaling to immunotherapy"
Date & Time: November 18, 2025 (Tue) 3:00pm – 4:00pm
Venue: NITORI Hall on 1st floor, CCII-BMS Bld.
Language: English
Registration: No registration required
Fee: Free
Contact: 075-753-9518
申し込み
不要
参加費
無料
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