Vijay Kuchroo 教授 (Harvard University / Brigham and Women's Hospital) をお招きして、特別講演会を開催します。
Kuchroo 教授は、Th17細胞 / 免疫exhaustion / 免疫チェックポイント分子 / 抗腫瘍免疫といった分野において、世界的にインパクトのある仕事をされています。
皆様のご参加を心よりお待ちしております。
開催日
-
2025/10/10
17:30～18:30
開催場所（方法）
医学部 基礎医学記念講堂
会場へのアクセスは以下をご参照ください（7番の建物）
https://www.kyoto-u.ac.jp/ja/access/campus/yoshida/map6r-i
詳細
【Speaker】Vijay K. Kuchroo, D.V.M., Ph.D.
Samuel L. Wasserstrom Professor of Neurology, Harvard Medical School
Director, The Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital
【Title】Checkpoint molecules, Tregs and induction of anti-tumor immunity
－チェックポイント分子、制御性T細胞、抗腫瘍免疫誘導－
【Language】English
【Eligibility】Researchers and students
【Abstract】
Expression of co-inhibitory receptors or “checkpoint” molecules, such as CTLA-4 and PD-1, on effector T cells is a key mechanism for ensuring immune homeostasis. Dysregulated expression of co-inhibitory receptors on CD4+ T cells promotes autoimmunity while sustained overexpression on CD8+ T cells promotes T cell dysfunction or exhaustion, leading to impaired ability to clear chronic viral infections and cancer. Immune checkpoint blockade (ICB) treatment by blocking CTLA4 and PD-1 has revolutionized cancer therapies, yet current ICB response rates are still relatively low. This suggests the need to discover novel checkpoint molecules and cell types where checkpoint molecules may be exerting additional or differential effects. We and others have discovered additional checkpoint molecules, including Tim-3, Lag-3, and TIGIT. Using RNA and protein expression profiling at single-cell resolution, we discovered that the checkpoint molecules are expressed as a module that is co-expressed and co-regulated on CD8 T cells, where they cooperatively induce T cell dysfunction. The same module of checkpoint molecules is also expressed on FoxP3+ Tregs, but their role in regulating immunity and anti-tumor immunity has not been fully appreciated. We have conditionally deleted checkpoint molecules on Foxp3+ Tregs and studied their role in regulating autoimmunity, tumor growth, and anti-tumor immunity. Studies with a number of the co-inhibitory molecules on Tregs in regulating anti-tumor immunity will be discussed.
申し込み
不要
参加費
無料
お問い合わせ
木村 公俊 (臨床神経学)
Email address: kimura[*]kuhp.kyoto-u.ac.jp
[*] を @ へ置き換えて下さい。