第37回 CCIIセミナー「The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma」 / "The 37th CCII Seminar: The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma”

Immune checkpoint inhibitors (ICI), which include monoclonal antibodies against PD-1 (e.g. nivolumab, pembrolizumab) and CTLA-4 (e.g. ipilimumab), have been the biggest breakthrough in the treatment of advanced melanoma. As not all patients respond to ICIs in melanoma, more work is needed to identify biomarkers that predict response as well as new drug targets. In 2015, we characterized a novel genetic subgroup of melanomas driven by loss-of-function (LoF) mutations in the RAS-GAP tumor suppressor, NF1, in ~15% of cases (TCGA, 2015). Subsequent next-generation sequencing studies (NGS) reported that mutations in NF1 are enriched in cutaneous melanoma patients responding to anti-PD-1 ICIs. The reason for this is not entirely clear. In my presentation, I will present data demonstrating how NF1 loss in melanoma promotes immune evasion through the PD-L1/PD-1 axis, which may help explain the improved anti-PD-1 responses observed in NF1 mutant melanoma patients. Our study provides support to investigate anti-PD-1 therapy in other malignancies with NF1 mutations.

開催日

  • 2025/7/9

    Wednesday, July 9
    3:00 PM – 4:00 PM

開催場所(方法)

京都大学がん免疫総合研究センター
Bristol Myers Squibb棟 1階 ニトリホール

※構内マップ「2番」の建物です
https://www.kyoto-u.ac.jp/ja/access/campus/yoshida/map6r-i

Nitori Hall
1st Floor, Bristol Myers Squibb Building,
Center for Cancer Immunotherapy and Immunobiology (CCII),
Kyoto University

*Located in Building No. 2 on the Campus Map
https://www.kyoto-u.ac.jp/en/access/medicine-campus-map

詳細

Dr. Ian Watson
Member, Rosalind and Morris Goodman Cancer Institute
Investigator, Research Institute-McGill University Health Center (RI-MUHC)
Canada Research Chair II in Functional Genomics of Melanoma
Associate Professor, Department of Biochemistry, McGill University

申し込み

不要

参加費

無料/Free

お問い合わせ

京都大学がん免疫総合研究センター
Center for Cancer Immunotherapy and Immunobiology (CCII)
kib.ccii.mem@mail2.adm.kyoto-u.ac.jp
https://www.ccii.med.kyoto-u.ac.jp/en/events/

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  3. 第37回 CCIIセミナー「The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma」 / "The 37th CCII Seminar: The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma”