開催日

• 2025/1/22

  16:00-17:00

開催場所（方法）

Building A, Room 103/107

詳細

A defining pathological feature of most neurodegenerative diseases is the assembly of proteins into amyloid that form disease-specific structures. I will present how using cryo-fluorescence microscopy (cryoFM)-targeted cryo-sectioning, cryo-focused ion beam scanning electron microscopy (cryoFIB-SEM) liftout and cryo-electron tomography (cryoET), we determined in-tissue molecular architectures in fresh mouse model and post-mortem human brain. Tomographic maps showed the architecture of β-amyloid and tau pathology. Subtomogram averaging of a microscopic region of pathology revealed the structure of a cluster of tau filaments from a single tomogram. These in situ structural approaches may be applied to address a broad range of neuroscience questions and I will also present how we are using these technologies to investigate the molecular architecture of mouse brain synapses.

申し込み

不要

お問い合わせ

Yasunori Hayashi
yhayashi-tky@umin.ac.jp
ext (16-)84393