MDM2 and its homolog MDM4 (also known as MDMX) are the two most important negative regulators of the tumor suppressor p53 by acting as an E3 ubiquitin ligase complex to promote p53 degradation and physically binding to inhibit the p53’s transcriptional functions. These proteins are overexpressed in about 30% of human cancers. Overexpression of MDM2/MDM4 not only inhibits p53 functions but also shows p53-independent oncogenic activities. Inhibitors against MDM2 and MDM4 have been developed to reactivate wild-type p53 in tumors, some of which are currently in clinical trials.
The MDM2 Workshop has been held alternately in the U.S. and Europe every two to three years to bring together the p53/MDM2 field, present the latest research, facilitate collaboration, and exchange reagents. The 10th International MDM2 Workshop will be held in Japan, for the first time in Asia. Notably, this is the first MDM2 Workshop since the COVID-19 pandemic started. The Workshop will be held at the auditorium of the National Cancer Center Research Institute (NCCRI) in Tokyo, Japan, on October 15-18, 2023.
The first day (Oct 15, 2023) 16:00~
The auditorium of the National Cancer Center Research Institute (NCCRI) in Tokyo, Japan
This workshop provides the chance for the participants to share and discuss their recent cancer research findings and learn more about Cancer Biology, Cancer Immunology and new exciting details of the key regulators p53 and MDM2.
You'll have the chance to listen to:
Donna George - University of Pennsylvania
Jamil Momand - California State University Los Angeles
Gerry Zambetti - St. Jude Children's Research Hospital
Guillermina Lozano - MD Anderson Cancer Center
Lubo Vassilev - EMD Serono
Binh Vu - PMVPharma
Matthias Dobbelstein - University of Göttingen
and many more
This workshop is organized by:
Rieko Ohki, National Cancer Center Research Institute, Tokyo, Japan
Koji Itahana, Duke-NUS Medical School, Singapore
Tomoo Iwakuma, Children’s Mercy Research Institute, Kansas City, MO, USA
Registration and Abstract Submission are now open!
(Poster award is 50,000 Yen)
Secretariat firstname.lastname@example.org (in English)
開催事務局 email@example.com (日本語)