Orthopaedic Surgery, Division of Reconstruction for Musculoskeletal DisordersMedicine and Medical Science

M.D., Ph.D. Program-Specific Professor Shunsuke Fujibayashi

The purpose of our research program is the reconstruction of musculoskeletal disorders in orthopaedic surgery. The loss of locomotor function reduces the patient’s quality of life. if it takes time to reconstruct the function, there is a risk of disuse syndrome and complications of other organ diseases. Rapid functional reconstruction using artificial joint, metal implant, and artificial bone is desired for such patients. We are developing patient-specific and disease-specific medical device for next-generation surgery.

Research and Education

Artificial joint:

We are developing original artificial hip joint implant, which have superior mechanical properties and biocompatibility. Currently we are developing bioactive bone cements for arthroplasties, as well as bioabsorbable screws for the reconstructive surgeries. The artificial knee joint aims to improve long-term durability and patient satisfaction by analyzing the knee joint kinematics using computer simulations.

Spinal fusion cage:

We have developed a spinal fusion cage using bioactive porous titanium porous and are applying it clinically.


We are developing artificial bones that have a high affinity with living bone. By applying special treatment to the surface of titanium metal and polymer, we are developing new artificial bones and artificial joints that have functions such as bone formation and antibacterial properties. And additive manufacturing technology is introduced to realize the patient-specific and disease-specific devices.

Figure1: Computer simulation of artificial knee joint

Figure2: Clinical trial of spinal fusion using custom-made bioactive porous titanium device.

Recent Publications

  1. Fujibayashi S, Takemoto M, Nakamura T, Matsushita T, Kokubo T, Sasaki K, Mori S, Matsuda S. Stand-Alone Anterior Cervical Discectomy and Fusion Using an Additive Manufactured Individualized Bioactive Porous Titanium Implant without Bone Graft: Results of a Prospective Clinical Trial. Asian Spine J. 2021 Jun;15(3):373-380.
  2. Fujibayashi S, Murata K, Shimizu T, Otsuki B, Masamoto K, Shimizu Y, Matsuda S. An Observational Survey of Nail and Skin of Spine Surgeons-Possible Damage by Occupational Ionizing Radiation Exposure. Spine Surg Relat Res. 2021 Feb 9;5(6):359-364.
  3. Nishitani K, Nakagawa Y, Kobayashi M, Nakamura S, Mukai S, Kuriyama S, Matsuda S. Long-Term Survivorship and Clinical Outcomes of Osteochondral Autologous Transplantation for Steroid-Induced Osteonecrosis of the Knee. Cartilage. 2021 Dec;13(1_suppl):1156S-1164S.
  4. Nishitani K, Ishikawa M, Morita Y, Yokogawa N, Xie C, de Mesy Bentley KL, Ito H, Kates SL, Daiss JL, Schwarz EM. IsdB antibody-mediated sepsis following S. aureus surgical site infection. JCI Insight. 2020 Oct 2;5(19):141164.
  5. Nakamura S, Kuriyama S, Ito H, Nishitani K, Song YD, Ikebe S, Higaki H, Matsuda S. Kinematic comparison between asymmetrical and symmetrical polyethylene inserts during deep knee bend activity. J Orthop Sci. 2021 May 24:S0949-2658(21)00137-8


Program-Specific Professor:Shunsuke Fujibayashi
Program-Specific Assistant Professor:Shinichiro Nakamura・Kohei Nishitani

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