Professor Sungrim Seirin-Lee
Our lab is developing a method that integrates mathematical model-driven and data-driven approaches to solve the mysteries of life science that approaches the essential question, “How were we created?”. In addition, for clinical medicine, where biological experiments themselves are difficult and the methods for solving them are extremely limited, we are constructing a new fusion research method that connects clinical medicine and cell biology experiments from the concept of “shape” by using mathematical modeling with a novel idea.
Research and Education
In recent years, interdisciplinary research of mathematics to solve life science problems has achieved significant growth and is about to change the times. Our lab is engaged in cutting-edge mathematical research, including the elucidation of developmental processes/pathophysiological mechanism in the life sciences/medicine. Our lab is developing a method that integrates mathematical model-driven and data-driven approaches to solve the mysteries of life science. In addition, for clinical medicine, where biological experiments themselves are difficult and the methods for solving them are extremely limited, we are constructing a new fusion research method that connects clinical medicine and mathematics from the concept of “shape”. We aim to create new concepts in the regulation of cell functions and to apply them to regenerative medicine and disease treatment by unraveling the mysteries of life based on “pattern and shape” as keywords. By discovering the universality (truth) of the life derived from mathematics, we aim to elucidate the principles underlying human biology and to pioneer a new mathematical medicine.
Chronic spontaneous urticaria (CSU). Wheal dynamics observed in patients and the regeneration of CSU pattern in skin by mathematical model.
Recent Publications
- S. Seirin-Lee*, K. Yamamoto, A. Kimura*,The extra-embryonic space and the local contour are critical geometric constraints regulating cell arrangement (2022) Development. 149,dev200401. doi:10.1242/dev.200401 (Press Released)
- S. Seirin-Lee, The role of cytoplasmic MEX-5/6 polarity in asymmetric cell division. Bulletin of Mathematical Biology. (2021) 83:29.
- S. Seirin-Lee, Y. Yanase, S. Takahagi, M. Hide, Multifarious Eruptions of Urticaria Solved by A Simple Mathematical Equation. PLOS Computational Biology (2020) 16(1): e1007590. (Press Released)
- S. Seirin-Lee, Fumitaka Osakada, Junichi Takeda, Satoshi Tashiro, Ryo Kobayashi, Takashi Yamamoto, Hiroshi Ochiai, Role of dynamic nuclear deformation on genomic architecture reorganization. PLOS Computational Biology (2019) 15 (8): e1007289. (Press Released)
Laboratory
[Professor] Sungrim Seirin-Lee
[ASHBi Program specific researchers] Antoine Diez, Hiroshi Ishii, Steffen Plunder, Tsubasa Skekawa
TEL: +81 75 753 98833
e-mail: bimed-math@mail2.adm.kyoto-u.ac.jp