Professor Yoichi Nabeshima
In this Department, we conduct cutting-edge aging research and train future researchers in health and aging medicine filed. Students will learn experimental methods to systematically analyze scientific questions from the molecular to individual levels along with various life stages, including skills in imaging analysis and mathematical modeling. Furthermore, we support students not only in developing experimental and in silico skills for their studies, but also in acquiring the ability to "find unique problems that "people haven't thought of," so that we will share the “Eureka moment” of science.
Research and Education
1) Professor: Yoichi Nabeshima:
We study aging mechanisms by analyzing nutrition, environment, and epigenomic status, and develop a large-scale AI-based system for cognitive assessment. we also study Alzheimer’s pathophysiology and develop novel diagnostics. Through these efforts, we will create innovative strategies to prevent cognitive decline, promote healthy aging, support longevity and deepen our understanding of “aging ias the survival strategies of organisms”.
2) Professor: Fumio Matsuzaki
We investigate the temporal dynamics of development and aging, concentrating on size regulation, maturation, and deterioration. We will identify mechanisms shaping the timing of these processes and their interconnections. By manipulating these timing mechanisms, we hope to inspire new perspectives on “time in life” including aging and longevity.
3) Associate Professor: Shinji Maegawa
We are developing methods to measure biological age and aging progression using the chemical modification of DNA (epigenome). We will analyze the effects of various drugs, nutritional conditions, genetic background, environmental factors, and the onset and progression of various diseases on epigenomic changes and attempt to elucidate the aging process.
Recent Publications
- Wu Q, Shichino Y, Abe T, Suetsugu T, Omori A, Kiyonari H, Iwasaki S, Matsuzaki F*. Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells. Nat Commun. 13(1):470. (2022)
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Merve Bilgic, Quan Wu , Taeko Suetsugu, Yuji Tsunekawa, Atsunori Sitamukai, Mitsutaka Kadota, Osamu Nishimura, Shigehiro Kuraku, and Fumio Matsuzaki. Truncated radial glia as a common precursor in the late corticogenesis of gyrencephalic mammals. eLife (2023). doi:
https://doi.org/10.7554/eLife.91406.2 - Mori M, Ruer-Laventie J, Duchemin W, Demougin P, Ndinyanka Fabrice T, Wymann MP, Pieters J. Suppression of caspase 8 activity by a coronin 1-PI3Kδ pathway promotes T cell survival independently of TCR and IL-7 signaling. Sci Signal. 14: eabj0057. (2021)
- Nabeshima Y, Abe C, Kawauchi T, Hiroi T, Uto Y, Nabeshima YI. Simple method for large-scale production of macrophage activating factor GcMAF. Sci Rep. 10(1):19122. (2020)
- Maegawa S*, Lu Y, Tahara T, Lee JT, Madzo J, Liang S, Jelinek J, Colman RJ, Issa JJ. Caloric restriction delays age-related methylation drift. Nat Commun. 8(1):539. (2017)
Laboratory
[Professor] Yoichi Nabeshima, Fumio Matsuzaki, Yoshihiro Uto, Minako Hoshi
[Associate Professor] Shinji Maegawa
[Senior Lecturer] Mayumi Mori, Quan Wu
[Assistant Professor] Chiaki Abe, Hirofumi Sogabe
TEL: 075-366-7482, and 7473
FAX: 075-366-7467