Professor Yoichi Nabeshima
In this Department, we conduct cutting-edge aging research and train future researchers in health and aging medicine filed. Students will learn experimental methods to systematically analyze scientific questions from the molecular to individual levels along with multiple time series, and will develop skills in imaging analysis and mathematical modeling. Furthermore, we support students in developing innovative techniques and equipments for their studies. By honing the ability to "find unique problems," we will conduct research that "people haven't thought of," and share the “Eureka moment” of science.
Research and Education
1) Professor: Yoichi Nabeshima:
We are analyzing the effects of nutrition, environment, time progression, and epigenomic status on the rate of aging, aging, and disease over the lifespan. We aim to elucidate the underlying mechanisms of aging and deepen our understanding of “the role of aging in the survival strategies of organisms”.
2) Professor: Fumio Matsuzaki
We are studying developmental and aging processes, focusing on how organs and tissues determine their size and complex function, and degeneration over time. We analyze the factors that affect the progression of time in each process and their relationship with diseases by manipulating these factors, laying the groundwork for a new perspective on understanding diseases associated with aging.
3) Associate Professor: Shinji Maegawa
We are developing methods to measure biological age and aging progression using the chemical modification of DNA (epigenome). We will analyze the effects of various drugs, nutritional conditions, genetic background, environmental factors, and the onset and progression of various diseases on epigenomic changes and attempt to elucidate the aging process.
Recent Publications
- Wu Q, Shichino Y, Abe T, Suetsugu T, Omori A, Kiyonari H, Iwasaki S, Matsuzaki F*. Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells. Nat Commun. 13(1):470. (2022)
- Mori M, Ruer-Laventie J, Duchemin W, Demougin P, Ndinyanka Fabrice T, Wymann MP, Pieters J. Suppression of caspase 8 activity by a coronin 1-PI3Kδ pathway promotes T cell survival independently of TCR and IL-7 signaling. Sci Signal. 14: eabj0057. (2021)
- Nabeshima Y, Abe C, Kawauchi T, Hiroi T, Uto Y, Nabeshima YI. Simple method for large-scale production of macrophage activating factor GcMAF. Sci Rep. 10(1):19122. (2020)
- Maegawa S*, Lu Y, Tahara T, Lee JT, Madzo J, Liang S, Jelinek J, Colman RJ, Issa JJ. Caloric restriction delays age-related methylation drift. Nat Commun. 8(1):539. (2017)
- Kobayashi K, Tanaka T, Okada S, Morimoto Y, Matsumura S, Manio MC, Inoue K, Kimura K, Yagi T, Saito Y, Fushiki T, Inoue H, Matsumoto M, Nabeshima YI. Hepatocyte β-Klotho regulates lipid homeostasis but not body weight in mice. FASEB J. 30(2):849-62. (2016)
Laboratory
[Professor] Yoichi Nabeshima, Fumio Matsuzaki
[Associate Professor] Shinji Maegawa
[Senior Lecturer] Mayumi Mori, Quan Wu
[Assistant Professor] Kanako Kobayashi, Chiaki Abe, Hirofumi Sogabe
TEL: 075-366-7482
FAX: 075-366-7467