Professor Yasuhiro Murakawa
Our ultimate goal is to create new scientific concepts and innovative medicine from the human genome information, which is the basic blueprint of the human body. We are developing state-of-the-art original genomic technologies that can solve new paradigms. In collaboration with hospitals and research institutes, we are building a large-scale human genome data and conducting medical research focusing on newly discovered genes in the human genome.
Research and Education
“What is encoded in the human genome” remains largely unknown. By combining classical biochemistry and systems biology, we investigate how many RNAs are transcribed from which genomic regions by which inputs, how they are post-transcriptionally regulated, and ultimately what functions they exert in each cell. Our lab members from various backgrounds are developing state-of-the-art technologies such as NET-CAGE, long-read sequencing, artificial intelligence and spatial single-cell transcriptomics. By discovering novel functional genetic elements including novel genes, non-coding RNAs and enhancers, we aim to establish new scientific concepts and innovative future medicine.
Major topics include
– Genomic platform for human genes including noncoding RNAs
– Human enhancer-mediated gene regulatory network
– Human disease genome research
– Genomic medicine and drug discovery
We welcome young scientists who believe that science has the power to fundamentally change the world, and who can pursue their research with curiosity and passion. As in “Jiju Jikei”, we encourage them to ask questions, learn on their own, and make actions based on their own personal values.
We use original functional genomic analysis methods to discover new genes in the human genome.
A photo from a lab event. Lab members from various backgrouds work together.
Recent Publications
- Hirabayashi S., Bhagat S., Matsuki Y., Takegami Y., Uehata T., Kanemaru A., Itoh M., Shirakawa K., Takaori-Kondo A., Takeuchi O., Carninci P., Katayama S., Hayashizaki Y., Kere J., Kawaji H., Murakawa Y. NET-CAGE Characterizes Dynamics and Topology of Human Transcribed Cis-regulatory Elements. Nature Genetics, 51(9):1369-1379 (2019)
- Yoshihara M., Araki A., Kasama Y., Sunayama M., Abe M., Nishida K., Kawaji H., Hayashizaki Y., Murakawa Y. Hotspots of de novo point mutations in induced pluripotent stem cells. Cell Reports, 21:308-315. (2017)
- Murakawa, Y., Yoshihara, M., Kawaji H., Nishikawa M., Zayed H., Suzuki H., Fantom Consortium, Hayashizaki Y. Enhanced identification of transcriptinal enhancers provides mechanistic insights into diseases. Trends in Genetics 32:76-88. (2016)
- Murakawa, Y., Hinz, M., Mothes, J., Schuetz, A., Yasuda, T., Mastrobuoni, G., Friedel, C.C., Dölken, L., Kempa, S., Schmidt-Supprian, M., Heinemann, U., Wolf, J, Scheidereit, C., Landthaler, M. RC3H1 represses the IKK/NF-κB negative feedback regulator A20 by binding to a 3’UTR composite structure-sequence element. Nature Communications, 6:7367. (2015)
- Rybak-Wolf, A. (#), Jens, M. (#), Murakawa, Y. (#), Herzog, M., Landthaler, M., Rajewsky, N. A variety of Dicer substrates in human and C.elegans. Cell, 159 1153-1167. (2014)
Laboratory
Professor: Yasuhiro Murakawa
Program-specific assistant professor: Kohei Hamanaka
Specially appointed assistant professor: Shruti Bhagat
TEL: +81-75-753-9891
e-mail: murakawa.yasuhiro.0r＠kyoto-u.ac.jp
URL: https://ashbi.kyoto-u.ac.jp/lab-sites/murakawa/