We conduct multi-omics studies of multigenetic disorders using genome, proteome and metabolome analysis technologies to elucidate their pathology and develop treatments. We aim to construct an integrative database of such information with detailed patients’ clinical information to enable the prediction, diagnosis, and best possible treatment and preventative intervention for each patient. Examples of diseases include multigenetic rare diseases, such as pulmonary hypertension, pulmonary fibrosis, IgG4-related disease, primary sclerosing cholangitis (PSC), and HTLV-1-associated myelopathy (HSM/TSP), caused by HTLV-1 infection. We also promote the Nagahama Study, Japan's first large-scale community-based genome cohort project. We are conducting prospective analyses of aging and age-related conditions using statistical genetics pipelines developed in-house to interpret the results.
The center has been actively engaged in research collaborations with overseas institutions. We established the International Joint Ph.D. Program in Genomic Medicine with McGill University in Canada, an educational program to foster world-leading life data scientists in genomic medicine. We also have a long-standing cooperation with Institut Pasteur, a world-leading institute in infectious diseases. We serve as a counterpart laboratory at Kyoto University for Institut Pasteur du Japan, established in June 2024.