Particle Radiation Oncology　(Radiation Oncology Research Laboratory Center, Institute for Integrated Radiation and Nuclear Science, Kyoto University )Medicine and Medical Science

M.D., Ph.D. Professor Minoru Suzuki

Boron neutron capture therapy (BNCT) has a unique feature which can deliver tumor-cell selective heavy-particle irradiation (Fig.1). At our institute, clinical studies on BNCT for malignant glioma and head and neck cancers using an accelerator based BNCT (Fig.2) have been carried out since 2012. The mission of our division is to carry out preclinical BNCT studies and to apply tumor-cell selective heavy-particle irradiation to radiation biology studies.

Lab Website

Research and Education

The main research subjects are as follows;

  1. Preclinical BNCT studies
    • Research on effect of BNCT for normal organs or tissues.
    • Research on development of new BNCT drugs in concert with other laboratories.
    • Research on combination of BNCT and immunotherapy
  2. Research on radiation biology studies using boron neutron capture irradiation.
  3. Preclinical research on BNCT for companion animals
  4. Research on gadolinium-neutron capture therapy (Gd-NCT)

Fig.1　Boron capture neutron reaction（Boron neutron capture irradiation） Nonradioactive isotope 10B atoms that absorb low-energy (<0.5 eV) neutrons (thermal neutrons) disintegrate into an alpha (4He) particle and a recoiled lithium nucleus (7Li). These particles deposit high energy along their very short path (<10 µm).

Fig.2 Schema of accelerator-based BNCT system

Recent Publications

  1. Shan Gao; Yutaka Miura; Akira Sumiyoshi; Satoshi Ohno; Keisuke Ogata; Takahiro Nomoto; Makoto Matsui; Yuto Honda; Minoru Suzuki; Megumi Iiyama; Kensuke Osada; Ichio Aoki; Nobuhiro Nishiyama.
    Self-Folding Macromolecular Drug Carrier for Cancer Imaging and Therapy.
    Advanced science, e2304171 2023
  2. Naonori Hu; Minoru Suzuki; Shin-ichiro Masunaga; Genro Kashino; Yuko Kinashi; Yi-Wen Chen; Yong Liu; Koki Uehara; Toshinori Mitsumoto; Hiroki Tanaka; Koji Ono.
    Experimentally determined relative biological effectiveness of cyclotron-based epithermal neutrons designed for clinical BNCT: in vitro study.
    Journal of Radiation Research 64: 811-815, 2023
  3. Tsubasa Watanabe; Tomohiro Yoshikawa; Hiroki Tanaka; Yuko Kinashi; Genro Kashino; Shin-Ichiro Masunaga; Toshimitsu Hayashi; Koki Uehara; Koji Ono; Minoru Suzuki.
    Pharmacokinetic Study of 14C-Radiolabeled p-Boronophenylalanine (BPA) in Sorbitol Solution and the Treatment Outcome of BPA-Based Boron Neutron Capture Therapy on a Tumor-Bearing Mouse Model.
    European journal of drug metabolism and pharmacokinetics 48:443-453, 2023
  4. Yucai Zhang; Heon Gyu Kang; Hua-Zhen Xu; Honghui Luo; Minoru Suzuki; Qing Lan; Xiao Chen; Naoki Komatsu; Li Zhao
    Tumor Eradication by Boron Neutron Capture Therapy with 10 B-enriched Hexagonal Boron Nitride Nanoparticles Grafted with Poly(glycerol).
    Advanced materials, e2301479, 2023
  5. Minoru Suzuki.
    Boron neutron capture therapy (BNCT): a unique role in radiotherapy with a view to entering the accelerator-based BNCT era. International journal of clinical oncology 25, 43 – 50, （2020）

Laboratory

Professor：Minoru Suzuki, M.D. Ph.D.
Associate Professor: Tsubasa Watanabe
Assistant Professor：Natsuko Kondo
Program-Specific Assistant Professor：Naonori Ko

URL:https://bnct.rri.kyoto-u.ac.jp

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