Professor, Ph.D. Taiji Adachi
Our research group aims to clarify the mechanisms by which cells sense mechanical stimuli and regulate their activities in tissue adaptation, regeneration and stem cell differentiation in morphogenesis. To better understand the mechano-regulation of these dynamical processes through the complex hierarchical structure-function relationships, bridging spatial and temporal scales from microscopic molecular/cellular activities to macroscopic tissue behaviors is very important. Based on multiscale biomechanics, our group is involved in the integrated biomechanics and mechanobiology researches of modeling and simulation combined with experiments, focusing on mechano-biochemical couplings in the system dynamics.
Research and Education
Living systems have the ability to functionally adapt to the changing mechanical environment by remodeling their structures dynamically at the organ, tissue, cellular and molecular levels. The mechanical environment also has an enormous influence on the dynamic rearrangement of the multicellular system during morphogenesis in tissue development as well as the remodeling of intracellular structures during cell division and cell migration. To address these interdisciplinary issues from mechanical viewpoints, we are conducting biomechanics research aiming to mechanically understand structural and functional dynamics at the molecular, cellular, and tissue levels, as well as mechanobiology research aiming to elucidate these biological functions. Our goal is to elucidate pathological mechanisms and develop innovative treatments for diseases based on a fundamental understanding of living systems by integrative approaches of biological experiments, mathematical modeling and computational simulation.
Fig. 1: Biomechanics of Bone Functional Adaptation
Fig. 2: Multiscale Biomechanics of Tissue Morphogenesis
Recent Publications
- Maki K, Fukute J, Adachi T. Super-resolution imaging reveals nucleolar encapsulation by single-stranded DNA. J Cell Sci, 137(20):jcs262039, 2024.
- Fukute J, Maki K, Adachi T. The nucleolar shell provides anchoring sites for DNA untwisting. Commun Biol, 7(1):83, 2024.
- Kim Y, Kameo Y, Tanaka S, Adachi T. Aging effects on osteoclast progenitor dynamics affect variability in bone turnover via feedback regulation. JBMR Plus, 8(1):ziad003, 2024.
- Yokoyama Y, Kameo Y, Sunaga J, Maki K, Adachi T. Chondrocyte hypertrophy in the growth plate promotes stress anisotropy affecting long bone development through chondrocyte column formation. Bone, 182:117055, 2024.
- Kameo Y, Miya Y, Hayashi M, Nakashima T, Adachi T. In silico experiments of bone remodeling explore metabolic diseases and their drug treatment. Sci Adv, 6(10):aax0938, 2020.
Laboratory
Professor：Taiji Adachi, Tel & Fax: +81-75-751-4853, E-mail: adachi@infront.kyoto-u.ac.jp
Associate Professor：Koichiro Maki, Tel & Fax: +81-75-751-4119, E-mail: maki@infront.kyoto-u.ac.jp
Assistant Professor：Young Kwan Kim, Tel & Fax: +81-75-751-4854, E-mail: ykim@infront.kyoto-u.ac.jp
Assistant Professor：Hironori Takeda, Tel & Fax: +81-75-751-4130, E-mail: takeda.hironori.3w@kyoto-u.ac.jp
Lab Homepage：http://www2.infront.kyoto-u.ac.jp/bf05/index-e.html