M.D., Ph.D. Director (concurrent service) Takashi Hanakawa
Human Brain Research Center (HBRC) conducts research on non-invasive brain imaging and stimulation to investigate brain structures, functions and its recovery by novel methodology. A human 7 Tesla MRI system, installed less than 100 in the world and 5 in Japan, has been installed here in addition to a MEG system. We are developing new rehabilitative approaches to induce brain plasticity and improve dysfunctions more efficiently by combining brain stimulation and rehabilitative tasks. We are exploring human brain structures, functions and recovery of disabled function by cutting edge techniques.
Research and Education
The human brain comprises the largest and most developed system among animal species. Brain research should be done in a comprehensive and integrative way based on dynamic networking activities, not only in a reductionistic way based on hierarchy.
We focus on basic brain functions, pathophysiology and functional recovery in neurological and psychiatric disorders by using 7-T MRI, MEG and high-resolutional EEG for evaluation, and transcranial magnetic stimulation (TMS), direct current stimulation (tDCS) and static magnetic stimulation (tSMS) for treatment. Our aim is to contribute to clinical medicine and welfare of patients. We carry out education of the graduate school by collaborating with various medical departments related to neuropsychiatric diseases, regardless of whether it is in or out of the university.
Brain imaging and Clinical Neurophysiology Field: We conduct non-invasive neuroimaging studies from basics to clinical applications, including usage of a 7T-MRI system and MEG.
Regenerative systems neuroscience: We conduct studies on recovery from brain dysfunction and disability by using hybrid rehabilitation techniques with non-invasive brain stimulation.
Recent Publications
- Sasaki R, Ohta Y, Onoe H, Yamaguchi R, Miyamoto T, Tokuda T, Tamaki Y, Isa K, Takahashi J, Kobayashi K, Ohta J, Isa T. Balancing Risk-Return Decisions by Manipulating the Mesofrontal Circuits in Primates. Science 383(6678):55-61, 2024. doi: 10.1126/science.adj6645.
- Kyuragi Y, Oishi N, Hatakoshi M, Hirano J, Noda T, Yoshihara Y, Ito Y, Igarashi H, Miyata J, Takahashi K, Kamiya K, Matsumoto J, Okada T, Fushimi Y, Nakagome K, Mimura M, Murai T, Suwa T. Segmentation and volume estimation of habenula using deep-learning in patients with depression. Biological Psychiatry: Global Open Science. 4(4):100314, 2024. doi: 10.1016/j.bpsgos.2024.100314
- Oi Y, Hirose M, Togo H, Yoshinaga K, Akasaka T, Okada T, Aso T, Takahashi R, Glasser MF, Hayashi T, Hanakawa T. Identifying and reverting the adverse effects of white matter hyperintensities on cortical surface analyses. NeuroImage 281:120377-120377, 2023. doi: 10.1016/j.neuroimage.2023.120377
- Nojima I, Horiba M, Sahashi K, Koganemaru S, Murakami S, Aoyama K, Matsukawa N, Ono Y, Mima T, Ueki Y. Gait-combined closed-loop brain stimulation can improve walking dynamics in Parkinsonian gait disturbances: a randomised-control trial. J Neurol Neurosurg Psychiatry. 94(11):938-944, 2023. doi: 10.1136/jnnp-2022-329966
- Okada T, Kuribayashi H, Urushibata Y, Fujimoto K, Akasaka T, Seethamraju RT, Ahn S, Isa T. GABA, glutamate and excitatory-inhibitory ratios measured using short-TE STEAM MRS at 7-Tesla: Effects of macromolecule basis sets and baseline parameters. Heliyon 9(7):e18357, 2023. doi: 10.1016/j.heliyon.2023.e18357
Laboratory
Director: Takashi Hanakawa, M.D., Ph.D.
Associate Professor: Naoya Oishi, M.D., Ph.D.
Program Specific Associate Professor: Madoka Matsumoto, Ph.D.
Program Specific Associate Professor: Ryuta Aoki, Ph.D.
Program Specific Assistant Professor: Dinh Ha Duy Thuy, M.D., Ph.D.
Research Associate: Shinichi Urayama, M.S.
Research Associate / Visiting Professor: Hirotaka Onoe, Ph.D.
Research Associate: Satoko Koganemaru, M.D., Ph.D.
TEL：+81-75-751-3695
FAX：+81-75-751-3202
e-mail：hbrcoffice@kuhp.kyoto-u.ac.jp
URL：http://hbrc.kuhp.kyoto-u.ac.jp/