M.D., Ph.D. Professor Yoshiki Arakawa
Neurosurgery has evolved as a field of neuroscience focused on the diagnosis and treatment of disorders in the nervous and vascular systems of the brain, spinal cord, and peripheral nerves. Our department is characterized by the practice of scientific clinical approaches, the development of innovative treatment methods based on foundational research, and the establishment of new evidence through high-quality clinical trials. We promote various joint research initiatives with other departments. Through these scientific approaches, our goal is to cultivate neurosurgeons with advanced knowledge and skills in the fields of neurosurgery.
Research and Education
In the realm of clinical research, our department assumes a pivotal role in nationwide studies, contributing high-quality evidence to the field. On the front of basic research, our investigations delve into the molecular mechanisms underlying various disorders. We strive to pioneer novel immunotherapy approaches for treating malignant brain tumors and develop advanced methodologies for high-resolution 3/7-tesla MRI and magnetoencephalography (MEG) in human brain imaging. Additionally, our focus extends to intraoperative brain functional mapping and monitoring. In our neuronal regeneration laboratory, we actively explore regenerative treatments for Parkinson’s disease and brain ischemia, utilizing both embryonic stem cells and induced pluripotent stem cells.
Our education system aims to produce highly skilled neurosurgeons who possess leadership qualities in the field. Trainees have ample opportunities to gain clinical experience and undergo skill training in the laboratory, enabling them to rapidly acquire the necessary skills for microsurgery and endovascular treatment. Additionally, trainees have the chance to learn specialized techniques in various neurosurgical subspecialties at related hospitals, including spine surgery, pediatric neurosurgery, and endovascular surgery.
Figure1. The subjects of our projects
Figure2. Members of the department in 2023
Recent Publications
- Sawada M, Kato K, Kunieda T, Mikuni N, Miyamoto S, Onoe H, Isa T, Nishimura Y. Function of the nucleus accumbens in motor control during recovery after spinal cord injury. Science. 2015;350(6256):98-101.
- Funaki T, Takahashi JC, Houkin K, Kuroda S, Fujimura M, Tomata Y, Miyamoto S. Effect of choroidal collateral vessels on de novo hemorrhage in moyamoya disease: analysis of nonhemorrhagic hemispheres in the Japan Adult Moyamoya Trial. Journal of neurosurgery. 2019;132(2):408-14.
- Terada Y, Jo N, Arakawa Y, Sakakura M, Yamada Y, Ukai T, Kabata M, Mitsunaga K, Mineharu Y, Ohta S, Nakagawa M, Miyamoto S, Yamamoto T, Yamada Y. Human Pluripotent Stem Cell-Derived Tumor Model Uncovers the Embryonic Stem Cell Signature as a Key Driver in Atypical Teratoid/Rhabdoid Tumor. Cell Rep. 2019;26(10):2608-21 e6.
- Yamao Y, Matsumoto R, Kunieda T, Nakae T, Nishida S, Inano R, Shibata S, Kikuchi T, Arakawa Y, Yoshida K, Ikeda A, Miyamoto S. Effects of propofol on cortico-cortical evoked potentials in the dorsal language white matter pathway. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2021;132(8):1919-26.
- Mellinghoff IK, van den Bent MJ, Blumenthal DT, Touat M, Peters KB, Clarke J, Mendez J, Yust-Katz S, Welsh L, Mason WP, Ducray F, Umemura Y, Nabors B, Holdhoff M, Hottinger AF, Arakawa Y, Sepulveda JM, Wick W, Soffietti R, Perry JR, Giglio P, de la Fuente M, Maher EA, Schoenfeld S, Zhao D, Pandya SS, Steelman L, Hassan I, Wen PY, Cloughesy TF. Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma. The New England journal of medicine. 2023.
Laboratory
M.D., Ph.D. Professor： Yoshiki Arakawa
Associate Professor： Akira Ishii
Program-Specific Associate Professor：Yohei Mineharu
Junior Associate Professor： Takayuki Kikuchi, Takeshi Funaki
Assistant Professor： Masakazu Okawa, Masahiro Tanji, Yukihiro Yamao, Noritaka Sano, Yu Abekura
Program-Specific Assistant Professor： Yukinori Terada
TEL: +81-75-751-3653
FAX: +81-75-771-6415
E-mail: nsgsec@kuhp.kyoto-u.ac.jp
Website: http://neurosur.kuhp.kyoto-u.ac.jp/