M.D., Ph.D. Professor Riki Matsumoto
Guided by our principle, "World Class Care and Research," we are dedicated to understand and protect the Brain to cure neurological disorders from the perspective of clinical neuroscience. We provide state-of-the-art medical care to patients with neurological diseases, investigate the pathophysiology of conditions such as Alzheimer’s disease, cerebrovascular disorders, Parkinson’s disease, amyotrophic lateral sclerosis, epilepsy, and neuroimmune diseases, develop new treatments, and educate the next generation of leading neurologists.
Research and Education
Our department conducts world-class research through three key laboratories. The Neuropathology Lab investigates neurodegenerative diseases, dementia, and cerebrovascular disorders using autopsy brains, immunohistochemical and biochemical studies, animal models, and human anatomical and functional imaging techniques. The Clinical Neurophysiology Lab have been promoting a variety of cutting-edge systems neuroscience research by applying various analytical methods such as connectome analysis and machine learning to EEG and neuroimaging, aiming to uncover mechanisms of epilepsy, dementia, and movement disorders. The Molecular Neuroscience Lab explores neurodegenerative disease mechanisms and therapies, focusing on Alzheimer’s, Parkinson’s, and multiple system atrophy, emphasizing protein aggregation and cell-to-cell transmission as key pathological processes. In education, our department is staffed by neurologists with deep expertise in neuroscience who provide both pre- and post-graduate clinical education for medical students and hands-on training for medical research students.
Kyoto University Neurology Retreat 2024
Recent Publications
- Delineating three distinct spatiotemporal patterns of brain atrophy in Parkinson’s disease. Sakato Y, Shima A, Terada Y, Takeda K, Sakamaki-Tsukita H, Nishida A, Yoshimura K, Wada I, Furukawa K, Kambe D, Togo H, Mukai Y, Sawamura M, Nakanishi E, Yamakado H, Fushimi Y, Okada T, Takahashi Y, Nakamoto Y, Takahashi R, Hanakawa T, Sawamoto N. Brain. 2024 147:3702-3713. doi: 10.1093/brain/awae303.
- Novel and reappraised wide-band EEG findings in migraineurs: Its correlation with several clinical variables. Hosokawa K, Usami K, Tatsuoka Y, Danno D, Takeshima T, Tatsuoka Y, Takahashi R, Ikeda A. Clin Neurophysiol. 2024 166:166-175. doi: 10.1016/j.clinph.2024.07.020.
- Acute inhibition of AMPA receptors by perampanel reduces amyloid β-protein levels by suppressing β-cleavage of APP in Alzheimer’s disease models. Ueda S, Kuzuya A, Kawata M, Okawa K, Honjo C, Wada T, Matsumoto M, Goto K, Miyamoto M, Yonezawa A, Tanabe Y, Ikeda A, Kinoshita A, Takahashi R. FASEB J. 2023 37:e23252. doi: 10.1096/fj.202300837R. PMID: 37850918
- Distinct connectivity patterns in human medial parietal cortices: Evidence from standardized connectivity map using cortico-cortical evoked potential. Togo M, Matsumoto R, Usami K, Kobayashi K, Takeyama H, Nakae T, Shimotake A, Kikuchi T, Yoshida K, Matsuhashi M, Kunieda T, Miyamoto S, Takahashi R, Ikeda A. Neuroimage 2022 263:119639. doi: 10.1016/j.neuroimage.2022.119639.
- α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson’s disease model. Taguchi T, Ikuno M, Hondo M, Parajuli LK, Taguchi K, Ueda J, Sawamura M, Okuda S, Nakanishi E, Hara J, Uemura N, Hatanaka Y, Ayaki T, Matsuzawa S, Tanaka M, El-Agnaf OMA, Koike M, Yanagisawa M, Uemura MT, Yamakado H, Takahashi R. Brain. 2020 143:249-265. doi: 10.1093/brain/awz380.
Laboratory
Professor: Riki Matsumoto
Associate Professor: Satoshi Kuzuya
Lecturer: Takakuni Maki
Assistant Professors: Takashi Ayaki, Katsuya Kobayashi, Etsuro Nakanishi, Sakihō Ueda
TEL:+81-75-751-4397
FAX:+81-75-751-9780
e-mail:neuroofc@kuhp.kyoto-u.ac.jp
URL:https://neurology.kuhp.kyoto-u.ac.jp/