D.D.S.,Ph.D. Professor Makoto Hirota
Goal of this department is to study the morphology, function and pathology of the oral and maxillofacial region, focusing on tooth, periodontal tissues and jaw bones, and develops human resources who can logically put theory into practice. We do practice regional medical care and examine medical safety to reduce the burden on patients. In addition, we conduct research to develop advanced medical care and devices to contribute research results to clinical oral surgery by using genetic analysis, bioengineering using biomaterials and CAD/CAM, AI technology, and epidemiological research.
Research and Education
We mainly conduct research on jaw bone lesions. In jaw deformities, we conduct research on the control of endochondral ossification to maxillofacial morphology to elucidate the onset mechanism, and in clinical research we work on developing
accurate surgery using CAD/CAM. In research on osteonecrosis and osteomyelitis of the jaw, we conduct clinical research on onset and related factors and basic research using an analysis of oral microbiota in the patients with osteonecrosis of the jaw based on 16sRNA sequencing. Also, we focus on the control of tooth number during the formation process, and aim to establish tooth regeneration treatment using model mice such as USAG-1 and C/EBPβ-deficient mice. In dental implant research, we apply ultraviolet irradiation to titanium surfaces to enhance adhesion to osteoblasts and bone integration. We are also conducting prospective cohort studies to identify genetic and environmental factors that are related to oral diseases and systemic diseases. Through these studies, we are also focusing on nurturing human resources who are familiar with medical safety and research ethics.
Recent Publications
- Fukuhara S, Watanabe T, Yamazaki T, Yamanaka S, Nakao K, Asai K, Kashiwagi M, Yamazaki A, Umebachi C, Setoh K, Tabara Y, Nakayama T, Matsuda F, Bessho K. Associations among tooth loss, periodontitis, and carotid intima-media thickness: the nagahama study. J Atheroscler Thromb 2023, 30, 1350-1363. Doi: 10.5551/jat.63801
- Kashiwagi M Nakao K, Yamanaka S, Yamauchi I, Yamashita T, Fujii T, Ueda Y, Kawai MY, Watanabe T, Fukuhara S, Bessho K. Circulatory C-type natriuretic peptide reduces mucopolysaccharidosis-associated craniofacial hypoplasia in vivo. PLoS One 2022, 17, e0277140. Doi:10.1371/journal.pone.0277140
- Watanabe T, Yoshida T, Akizuki S, Yamanaka S, Nakao K, Fukuhara S, Asai K, Uozumi R, Bessho K. Nonexposed antiresorptive agent-related osteomyelitis of the jaw: a single-center cohort study. J Bone Miner Metab 2022, 40, 657-662. Doi:10/1007/s00774-022-01329-3.
- Mishima S, Takahashi K, Kiso H, Murashima-Suginami A, Tokita Y, Jo JI, Uozumi T, Nambu Y, Huang B, Harada H, Komori T, Sugai M, Tabata Y, Bessho K. Local application of Usag-1 siRNA can promote tooth regeneration in Runx2-deficient mice. Sci Rep 2021, 11, 13764. Doi:10.1038/s41598-021-93256-y.
- Hirota M, Ozawa T, Iwai T, Ogawa T, Tohnai I. Effect on photofunctionalization on early implant failure. Int J Oral Maxillofac Implants 2018, 33, 1008-1102. Doi: 10.11670/jomi.6541.
Laboratory
Professor：Makoto Hirota, D.D.S., Ph.D.
Associate Professor：Kazumasa Nakao, D.D.S., Ph.D.
Lecturer：Keita Asai, D.D.S., Ph.D.
Assistant Professor：Sayaka Mishima, D.D.S., Ph.D.
Assistant Professor：Takuma Watanabe, D.D.S., Ph.D.
Assistant Professor：Shigeki Yamanaka, D.D.S., Ph.D.
Specific hospital Assistant Professor：Atsue Yamazaki, D.D.S., Ph.D.
Specific hospital Assistant Professor：Shizuko Fukuhara, D.D.S., Ph.D.
TEL:+81-75-751-3401
FAX:+81-75-761-9732
e-mail: oralsecr@kuhp.kyoto-u.ac.jp