M.D., Ph.D. Professor Miki Nagao
Our department promotes clinical practice, education, and research in laboratory medicine, infectious diseases, and clinical microbiology. We are engaged in deciphering epidemiological information ranging from the micro to the macro level, while also working on the development of highly accurate diagnostic technologies and the establishment of solid evidence for effective treatments. Aiming to create a society resilient to infectious diseases, we actively collaborate not only within clinical medicine but also across diverse disciplines.
Research and Education
Infection is caused by a variety of pathogens from a virion to a multicellular parasite, while infected hosts show a range of immunological status from completely healthy to severely immunocompromised. Many modalities such as microscopical examination, culturing, direct detection of antigens or genomes, are now available for the identification of causative pathogens leading to the initiation of optimal treatment. However, the correct cause cannot always be accurately identified, so that there is a growing need for the development and practical application of new technologies. To meet this need, we are cooperating with the clinical laboratory of Kyoto University Hospital and with many industries for the development and practical use of novel diagnostic methods for infectious diseases. Unfortunately, the resources for adequate education in and management of infectious diseases in Japan have been insufficient compared with those available in other developed countries. To improve this situation, scientific rationality, rather than unsubstantiated “authoritative” comments, must take priority for better practice with regard to infectious diseases. At Kyoto University Hospital, we have been providing a sophisticated consultation service regarding efficient diagnostic procedures and appropriate management of patients with severe infection, which has resulted in a steady improvement of the prognosis for patients with nosocomial sepsis. In addition, we are educating both medical students and residents in the management of patients with infectious diseases on the basis of up-to-date clinical evidence.
Whole-Genome Analysis for Estimating the Divergence of Multidrug-Resistant E. coli ST131 Clones
Recent Publications
- Integrating whole-genome sequencing into antimicrobial resistance surveillance: methodologies, challenges, and perspectives.
Matsumura Y, Yamamoto M, Gomi R, Tsuchido Y, Shinohara K, Noguchi T, Nagao M.
Clin Microbiol Rev. 2025 Sep 5:e0014022. PMID: 40910632 Review. - An 11-year multicentre clinical and genomic surveillance of listeriosis across Japan.
Shinohara K, Tsuda Y, Tsuchido Y, Yamamoto M, Matsumura Y, Nagao M.
J Infect. 2025 Aug;91(2):106552. Epub 2025 Jul 18.PMID: 40684886 - Epidemiology of respiratory viruses according to age group, 2023-24 winter season, Kyoto, Japan.
Matsumura Y, Yamamoto M, Tsuda Y, Shinohara K, Tsuchido Y, Yukawa S, Noguchi T, Takayama K, Nagao M.
Sci Rep. 2025 Jan 6;15(1):924. doi: 10.1038/s41598-024-85068-7. PMID: 39762485 - Development and evaluation of three automated media pooling and molecular diagnostic systems for the detection of SARS-CoV-2.
Matsumura Y, Noguchi T, Shinohara K, Yamamoto M, Nagao M.
Microbiol Spectr. 2024 Mar 5;12(3):e0368423. Epub 2024 Jan 30. PMID: 38289934 - Clonal expansion of multidrug-resistant Streptococcus dysgalactiae Subspecies equisimilis causing bacteremia, Japan, 2005-2021.
Shinohara K, Murase K, Tsuchido Y, Noguchi T, Yukawa S, Yamamoto M, Matsumura Y, Nakagawa I, Nagao M. Emerg Infect Dis. 2023 Mar;29(3):528-539. PMID: 36823027; PMCID: PMC9973691.
Laboratory
Professor : Miki Nagao
Associate Professor : Yasufumi Matsumura
Senior Lecturer : Masaki Yamamoto, Yasuyuki Arai
Assistant Professor : Tomoyasu Jo, Yasuhiro Tsuchido, Kiyohide Usami, Koh Shinohara
Program-Specific Assistant Professor, University Hospital : Yusuke Tsuda, Yutarou Miyoshi
TEL： +81-75-751-3502
FAX： +81-75-751-3233
e-mail：kensa@med.kyoto-u.ac.jp