Clinical Laboratory MedicineMedicine and Medical Science

M.D., Ph.D. Professor Miki Nagao

Emerging and re-emerging infectious diseases and increasing drug resistance in various pathogenic microorganisms have created a worldwide interest in infectious diseases. Our aims are to develop novel diagnostic methodologies and to identify clinical evidence that will lead to more efficient management of infectious diseases. Our mission is to develop young, promising clinicians and investigators who will take an active part internationally in the fields of clinical infectious diseases, infection epidemiology, and clinical microbiology.

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Research and Education

Infection is caused by a variety of pathogens from a virion to a multicellular parasite, while infected hosts show a range of immunological status from completely healthy to severely immunocompromised. Many modalities such as microscopical examination, culturing, direct detection of antigens or genomes, are now available for the identification of causative pathogens leading to the initiation of optimal treatment. However, the correct cause cannot always be accurately identified, so that there is a growing need for the development and practical application of new technologies. To meet this need, we are cooperating with the clinical laboratory of Kyoto University Hospital and with many industries for the development and practical use of novel diagnostic methods for infectious diseases. Unfortunately, the resources for adequate education in and management of infectious diseases in Japan have been insufficient compared with those available in other developed countries. To improve this situation, scientific rationality, rather than unsubstantiated “authoritative” comments, must take priority for better practice with regard to infectious diseases. At Kyoto University Hospital, we have been providing a sophisticated consultation service regarding efficient diagnostic procedures and appropriate management of patients with severe infection, which has resulted in a steady improvement of the prognosis for patients with nosocomial sepsis. In addition, we are educating both medical students and residents in the management of patients with infectious diseases on the basis of up-to-date clinical evidence.

Time-scaled phylogeny of multi-drug resistant Escherichia coli ST131 genomes

Diagnostic performance of SARS-CoV-2 detection assays

Recent Publications

  1. Analysis of a city-wide COVID-19 prevention strategy for aged-care facilities during third and fifth waves of COVID-19 in Kyoto City, Kyoto, Japan.
    Nagao M, Matsumura Y, Yamamoto M, Shinohara K, Yukawa S, Noguchi T, Tsuchido Y, Ikeda T.
    Influenza Other Respir Viruses. 2022 Mar 9. doi: 10.1111/irv.12981.
  2. Prospective multicenter surveillance of clinically isolated Aspergillus species revealed azole-resistant Aspergillus fumigatus isolates with TR34/L98H mutation in the Kyoto and Shiga regions of Japan.
    Tsuchido Y, Tanaka M, Nakano S, Yamamoto M, Matsumura Y, Nagao M.
    Med Mycol. 2019 Nov 1;57(8):997-1003. doi: 10.1093/mmy/myz003.
  3. Role of TEM-1 β-Lactamase in the Predominance of Ampicillin-Sulbactam-Nonsusceptible Escherichia coli in Japan.
    Noguchi T, Matsumura Y, Kanahashi T, Tanaka M, Tsuchido Y, Matsumura T, Nakano S, Yamamoto M, Nagao M, Ichiyama S.
    Antimicrob Agents Chemother. 2019 Jan 29;63(2):e02366-18. doi: 10.1128/AAC.02366-18.
  4. Molecular Analysis of a bla(IMP-1)-Harboring Class 3 Integron in Multidrug-Resistant Pseudomonas fulva.
    Yamamoto M, Matsumura Y, Gomi R, Matsuda T, Nakano S, Nagao M, Tanaka M, Ichiyama S. Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00701-18.
  5. Complete adherence to evidence-based quality-of-care indicators for Staphylococcus aureus bacteremia resulted in better prognosis.
    Nagao M, Yamamoto M, Matsumura Y, Yokota I, Takakura S, Teramukai S, Ichiyama S.
    Infection 2017 Feb;45(1):83-91.


Professor : Miki Nagao
Associate Professor : Yasufumi Matsumura
Senior Lecturer : Takefumi Hitomi, Masaki Yamamoto
Assistant Professor : Yasuyuki Arai, Eri Kato, Taro Noguchi, Tomoyasu Jo, Yasuhiro Tsuchido, Satomi Yukawa, Koh Shinohara

TEL: +81-75-751-3502
FAX: +81-75-751-3233

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