M.D., Ph.D. Professor Miki Nagao
Emerging and re-emerging infectious diseases and increasing drug resistance in various pathogenic microorganisms have created a worldwide interest in infectious diseases. Our aims are to develop novel diagnostic methodologies and to identify clinical evidence that will lead to more efficient management of infectious diseases. Our mission is to develop young, promising clinicians and investigators who will take an active part internationally in the fields of clinical infectious diseases, infection epidemiology, and clinical microbiology.
Research and Education
Infection is caused by a variety of pathogens from a virion to a multicellular parasite, while infected hosts show a range of immunological status from completely healthy to severely immunocompromised. Many modalities such as microscopical examination, culturing, direct detection of antigens or genomes, are now available for the identification of causative pathogens leading to the initiation of optimal treatment. However, the correct cause cannot always be accurately identified, so that there is a growing need for the development and practical application of new technologies. To meet this need, we are cooperating with the clinical laboratory of Kyoto University Hospital and with many industries for the development and practical use of novel diagnostic methods for infectious diseases. Unfortunately, the resources for adequate education in and management of infectious diseases in Japan have been insufficient compared with those available in other developed countries. To improve this situation, scientific rationality, rather than unsubstantiated “authoritative” comments, must take priority for better practice with regard to infectious diseases. At Kyoto University Hospital, we have been providing a sophisticated consultation service regarding efficient diagnostic procedures and appropriate management of patients with severe infection, which has resulted in a steady improvement of the prognosis for patients with nosocomial sepsis. In addition, we are educating both medical students and residents in the management of patients with infectious diseases on the basis of up-to-date clinical evidence.
Time-scaled phylogeny of multi-drug resistant Escherichia coli ST131 genomes
Diagnostic performance of SARS-CoV-2 detection assays
Recent Publications
- Development and evaluation of three automated media pooling and molecular diagnostic systems for the detection of SARS-CoV-2. Matsumura Y, Noguchi T, Shinohara K, Yamamoto M, Nagao M. Microbiol Spectr. 2024 Mar 5;12(3):e0368423.
- A population-based study of the trend in SARS-CoV-2 diagnostic modalities from the beginning of the pandemic to the Omicron surge in Kyoto City, Kyoto, Japan. Kyo H, Patel SA, Yamamoto M, Matsumura Y, Ikeda T, Nagao M. BMC Public Health. 2023 Dec 21;23(1):2551.
- Clonal Expansion of Multidrug-Resistant Streptococcus dysgalactiae Subspecies equisimilis Causing Bacteremia, Japan, 2005-2021. Shinohara K, Murase K, Tsuchido Y, Noguchi T, Yukawa S, Yamamoto M, Matsumura Y, Nakagawa I, Nagao M. Emerg Infect Dis. 2023 Mar;29(3):528-539.
- Transmissibility of SARS-CoV-2 B.1.1.214 and Alpha Variants during 4 COVID-19 Waves, Kyoto, Japan, January 2020-June 2021. Matsumura Y, Nagao M, Yamamoto M, Tsuchido Y, Noguchi T, Shinohara K, Yukawa S, Inoue H, Ikeda T. Emerg Infect Dis.2022 Aug;28(8):1569–77.
- Prospective multicenter surveillance of clinically isolated Aspergillus species revealed azole-resistant Aspergillus fumigatus isolates with TR34/L98H mutation in the Kyoto and Shiga regions of Japan. Tsuchido Y, Tanaka M, Nakano S, Yamamoto M, Matsumura Y, Nagao M. Med Mycol. 2019 Nov 1;57(8):997-1003.
Laboratory
Professor : Miki Nagao
Associate Professor : Yasufumi Matsumura
Senior Lecturer : Masaki Yamamoto, Yasuyuki Arai
Assistant Professor : Tomoyasu Jo, Satomi Yukawa, Yasuhiro Tsuchido, Kiyohide Usami
Program-Specific Assistant Professor, University Hospital : Koh Shinohara, Yusuke Tsuda, Yutarou Miyoshi
TEL： +81-75-751-3502
FAX： +81-75-751-3233
e-mail：kensa@med.kyoto-u.ac.jp