Research and Education

Biological approach

We are promoting a wide-range of basic cancer research including the development of new radiosensitizers, comprehensive analysis to identify factors contributing to tumor radio-resistance, research on neutrophil extracellular traps (NETs), omics analysis using clinical specimens, and complement-targeted radiotherapy. In addition, we collaborate with Radiation Biology Center for research on hypoxia, and with Institute for Integrated Radiation and Nuclear Science for research on BNCT and immune-radiotherapy.

Physical engineering approach

We are developing a high-precision image-guided radiotherpy system (OXRAY) and are in the process of clinical evaluation in collaboration with a domestic company. In particular, we are advancing the development of innovative irradiation techniques such as high-precision radiotherapy and innovative beam-delivery techniques, including dynamic tumor-tracking and Dynamic SwingArc irradiation. Our final goal is to perform personalized radiotherapy based on molecular-tracking radiotherapy, which fuses biological approaches with physical techniques.

Clinical research

We aim to apply results from radiobiological and physical research to clinical practice. We are conducting clinical trials on multidisciplinary treatment, which combines high-precision radiotherapy with surgery/chemotherapy.

Neutrophil extracellular traps (NETs, shown in green) triggered by intravascular redox imbalance entrap circulating tumor cells (shown in red) at the lungs and promote pulmonary metastasis.

High-precision image-guided radiation therapy device (OXRAY)

Recent Publications

1. Hiraoka S, Hirashima H, Nakamura M, Tanaka F, Adachi H, Ono Y, Ono T, Nakashima R, Nakajima A, Mizowaki T. Integration Test of Biaxially Rotational Dynamic-Radiation Therapy for Nasopharyngeal Carcinoma: Efficacy Evaluation and Dosimetric Analysis. Radiother Oncol. in press, 2025.
2. Iizuka Y, Inoue M, Kokubo M, Sakamoto T, Murofushi KN, Imagumbai T, Shimizuguchi T, Hiraoka M, Mizowaki T. Long-term results of dynamic tumor-tracking stereotactic body radiotherapy with real-time monitoring using a gimbal-mounted linac for liver tumors: a multicenter observational study. Int J Clin Oncol. 2025 Mar 21.
3. Yoshimura M, Hiraoka M, Kokubo M, Sakamoto T, Karasawa K, Matsuo Y, Nakamura M, Mukumoto N, Morita S, Mizowaki T. Multi-Institutional Phase II Study on the Efficacy and Safety of Dynamic Tumor-Tracking, Moderately Hypofractionated Intensity-Modulated Radiotherapy in Patients With Locally Advanced Pancreatic Cancer. Cancer Med. 2025;14:e70648.
4. Hirashima H, Adachi H, Ono T, Nakamura M, Ono Y, Iwai T, Yoshimura M, Mizowaki T. Determination of patient-specific trajectory for biaxially rotational dynamic-radiation therapy using a new O-ring-shaped image guided radiotherapy system. Physics and Imaging in Radiation Oncology. 2025;33:100698.
5. Yoneyama M, Matsuo Y, Kishi N, Itotani R, Oguma T, Ozasa H, Tanizawa K, Handa T, Hirai T, Mizowaki T. Quantitative analysis of interstitial lung abnormalities on computed tomography to predict symptomatic radiation pneumonitis after lung stereotactic body radiotherapy. Radiother Oncol. 2024;198:110408.

Laboratory

Professor：Takashi Mizowaki
Associate Professor：Michio Yoshimura
Senior lecturer：Katsuyuki Sakanaka・Yusuke Iizuka
Program-Specific Senior Lecturer：Megumi Uto
Assistant Professor：Ryota Nakashima・Yuka Ono・Rihito Aizawa・Tatsuya Suwa
Program-Specific Assistant Professor：Noriko Kishi・Shinya Hiraoka・Hideaki Hirashima・Takanori Adachi・Yukako Kishigami
Program-Specific Assistant Professor, University Hospital：Takashi Ogata・Masahiro Yoneyama

TEL：+81-75-751-3417
FAX：+81-75-771-9749
e-mail：radonc_office@kuhp.kyoto-u.ac.jp
URL：http://radiotherapy.kuhp.kyoto-u.ac.jp