Radiation Oncology and Image-Applied TherapyMedicine and Medical Science

M.D., Ph.D. Professor Takashi Mizowaki

We are developing innovative radiotherapy technology to eradicate cancers. In molecular biological research, we investigate causes for radioresistances and create methods to overcome them by analyzing DNA, RNA, proteins, etc., in experimental samples and clinical human cancer samples. In physical engineering research, we are driving forward high-precision radiotherapy such as intensity-modulated radiotherapy (IMRT), stereotactic radiotherapy, and four-dimensional radiotherapy. We welcome the participation of physicians, biologists, and physical engineers who are interested in these translational approaches to cancer therapy.

Lab Website

Research and Education

Biological approach

We are promoting a wide range of basic research,development of new radiosensitizers, omics analysis of genomes, and modeling cell dynamics after irradiation with deep learning AI approaches. In addition, we collaborate with the Laboratory of Cancer Cell Biology of Kyoto University for research on the mechanism of cancer cells in microbiology and the Institute for Integrated Radiation and Nuclear Science for basic research of boron neutron capture therapy (BNCT) and immune-radiotherapy.

Physical engineering approach

We are developing high-precision radiotherapy and innovative beam delivery technique, including dynamic tumor-tracking and Dynamic WaveArc irradiation, as well as their treatment plans and quality control. Our final goal is to perform personalized radiotherapy based on molecular tracking radiotherapy, which fuses biological approaches with physical techniques.

Clinical research

We aim to apply results from radiobiological and physical research to clinical practice. We are conducting clinical trials on multidisciplinary treatment, which combines high-precision radiotherapy with surgery/chemotherapy. Systemic organs can be our target: brain, lung, breast, esophagus, pancreas, prostate, rectum, anal canal, etc.

Neutrophil extracellular traps (NETs, shown in green) triggered by intravascular redox imbalance entrap circulating tumor cells (shown in red) at the lungs and promote pulmonary metastasis.

r-042-2 Dynamic tracking irradiation with (Vero4DRT) high precision image-guided radiation therapy device, which was developed in conjunction

Recent Publications

  1. Matsuo Y, Hiraoka M, Karasawa K, Kokubo M, Sakamoto T, Mukumoto N, Nakamura M, Morita S, Mizowaki T. Multi-institutional phase II study on the safety and efficacy of dynamic tumor tracking-stereotactic body radiotherapy for lung tumors. Radiother Oncol. 2022;172:18-22. doi:10.1016/j.radonc.2022.04.028
  2. Ono T, Nakamura M, Ono Y, Nakamura K, Mizowaki T. Development of a plan complexity mitigation algorithm based on gamma passing rate predictions for volumetric-modulated arc therapy. Med. Phys., 49, 1793~1802, 2022. doi : 10.1002/mp.15466
  3. Inoue M, Enomoto M, Yoshimura M, Mizowaki T. Pharmacological inhibition of sodium-calcium exchange activates NADPH oxidase and induces infection-independent NETotic cell death. Redox Biology, 2021 ;43:101983. doi: 10.1016/j.redox.2021. 101983.
  4. Hirashima H, Nakamura M, Baillehache P, Fujimoto Y, Nakagawa S, Saruya Y, Kabasawa T, Mizowaki T. Development of in-house fully residual deep convolutional neural network-based segmentation software for the male pelvic CT. Radiat. Oncol., 16, 135, 2021. doi: 10.1186/s13014-021-01867-6
  5. Aizawa R, Takayama K, Nakamura K, Inoue T, Yamasaki T, Kobayashi T, Akamatsu S, Ogawa O, Mizowaki T. Ten-year outcomes of high-dose intensity-modulated radiation therapy for nonmetastatic prostate cancer with unfavorable risk: early initiation of salvage therapy may replace long-term adjuvant androgen deprivation. Int J Clin Oncol. 2019; 10:1247-1255. doi: 10.1007/s10147-019-01478-y

Laboratory

Professor：Takashi Mizowaki
Associate Professor：Yukinori Matsuo
Senior Lecturer：Michio Yoshimura・ Katsuyuki Sakanaka
Assistant professor： Aya Nakajima・Minoru Inoue・Ryota Nakashima ・Megumi Uto
Program-Specific Assistant professor：Yuka Ono・Rihito Aizawa・Noriko Kishi・Tomohiro Ono・Hiraku Iramina・Hideaki Hirashima・Takanori Adachi

TEL：+81-75-751-3417
FAX：+81-75-771-9749
e-mail：radonc_office@kuhp.kyoto-u.ac.jp
URL：http://radiotherapy.kuhp.kyoto-u.ac.jp

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