PediatricsMedicine and Medical Science

M.D. Professor Junko Takita

The most important thing in the Pediatrics is “development”. A number of pediatric diseases are derived from the disorders during developmental process. Therefore, investigations on them should lead to the exploitation of new diagnosis and treatment for intractable diseases. By imposing close relationship between clinic and laboratory on our research, we would like to apply our outcomes obtained from clinic and laboratory to children with intractable diseases.

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Research and Education

As a clinical department, further developing translational research is the most important mission in order to provide optimized and high-quality medicine for patients. Therefore, to elucidate molecular mechanisms and develop new therapeutic strategies of intractable pediatric diseases, we currently perform multi-omics analysis using genetic and epigenetic approaches. In addition, we also apply human iPS cell technology to get a better understanding of etiologies of congenital diseases and establish regenerative medicine for patients with intractable diseases. Our research projects are aiming to contribute to the development of pediatric research as well as life science. We will continue to foster and inspire excellent physician scientists who devote their professional effort seeking new knowledge about basic research to care patients.

Recent Publications

  1. Clinical Characteristics of Cryopyrin-Associated Periodic Syndrome and Long-Term Real-World Efficacy and Tolerability of Canakinumab in Japan: Results of a Nationwide Survey. Miyamoto T, Izawa K, Masui S, Yamazaki A, Yamasaki Y, et al. .Arthritis Rheumatol. 2024 Jan 25. doi: 10.1002/art.42808. Online ahead of print.
  2. RNA-seq-based miRNA signature as an independent predictor of relapse in pediatric B-cell acute lymphoblastic leukemia. Kubota H, Ueno H, Tasaka K, Isobe T, Saida S, Kato I, Umeda K, Hiwatari M, Hasegawa D, Imamura T, Kakiuchi N, Nannya Y, Ogawa S, Hiramatsu H, Takita J.Blood Adv. 2024 Mar 12;8(5):1258-1271. doi: 10.1182/bloodadvances.2023011583.
  3. HOIL-1L deficiency induces cell cycle alteration which causes immaturity of skeletal muscle and cardiomyocytes. Akagi K, Baba S, Fujita H, Fuseya Y, Yoshinaga D, Kubota H, Kume E, Fukumura F, Matsuda K, Tanaka T, Hirata T, Saito MK, Iwai K,Takita J.Sci Rep. 2024 Apr 17;14(1):8871. doi: 10.1038/s41598-024-57504-1.
  4. Severe Bronchopulmonary Dysplasia Adversely Affects Brain Growth in Preterm Infants. Shimotsuma T, Tomotaki S, Akita M, Araki R, Tomotaki H, Iwanaga K, Kobayashi A, Saitoh A, Fushimi Y, Takita J, Kawai M.Neonatology. 2024 Apr 22:1-9. doi: 10.1159/000538527. Online ahead of print.
  5. Involvement of mTOR pathway in neurodegeneration in NSF-related developmental and epileptic encephalopathy. Hayashi T, Yano N, Kora K, Yokoyama A, Maizuru K, Kayaki T, Nishikawa K, Osawa M, Niwa A, Takenouchi T, Hijikata A, Shirai T, Suzuki H, Kosaki K, Saito MK, Takita J, Yoshida T.Hum Mol Genet. 2023 May 5;32(10):1683-1697. doi: 10.1093/hmg/ddad008.


M.D., PhD. Professor: Junko Takita
Professor (Special Appointment): Masahiko Kawai
Associate Professor: Katsutsugu Umeda
Junior Associate Professor: Shiro Baba, Kazushi Izawa, Itaru Kato
Assistant Professor: Takuya Hirata, Atsushi Yokoyama, Satoshi Saida, Kogoro Iwanaga, Hiroko Tomotaki, Takeshi Yoshida, Seiichi Tomotaki, Yukako Maeda, Takenori Suga, Kentaro Akagi, Hirohito Kubota, Hiroshi Nihira, Ryosuke Araki, Naoko Yano, Ryo Akazawa


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