Gastroenterology and HepatologyMedicine and Medical Science

M.D., Ph.D. Professor Hiroshi Seno

Our department has been established in 1996. As a clinical department, our goal is to produce not only many good clinical specialists for gastroenterology who can understand both clinical medicine and basic science but also researchers for basic gastroenterology. As a clinical department, we cover all the field of gastroenterology, while in the research field we are particularly focusing on oncology, immunology and development and differentiation. Our final goal is to create new modalities for treatment of various gastroenterological diseases.

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Research and Education

Period of residency is very important for young doctors to become good physicians. So, we are doing our best to educate young doctors to become general internists as well as specialists for gastroenterology. In particular, after finishing residency, we prepare a special course for training clinical gastroenterology. Our research projects cover liver diseases, pancreato-biliary diseases, and upper and lower gastrointestinal tract diseases. Particularly, we are focusing on cancers, immunological diseases such as inflammatory bowel disease, and regeneration of gastrointestinal organs. For recent years, we have clarified significance of occult infection of HBV in the development of liver cancer, roles of immunological responses to H. pylori in the development of various gastric diseases such as gastric cancer and MALT lymphoma, and mechanisms for inflammation-associated carcinogenesis, and identified a novel cancer stem cell marker. We have also developed a novel method for treating IBD. Moreover, we made significant contribution to establishing the concept of autoimmune pancreatitis. Now, we are working hard to establish treatment for various gastrointestinal cancers and IBD.

Members of the laboratory.

Recent Publications

  1. Omatsu M, et al. THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer. Nat Commun. 2023 Sep 25;14(1):5534.
  2. Masuda T, et al., Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis. J Clin Invest. 2023 Sep 15;133(18):e161847.
  3. Fukunaga Y, et al. Loss of Arid1a and Pten in pancreatic ductal cells induces intraductal tubulopapillary neoplasm via the YAP/TAZ pathway. Gastroenterology. 2022 Aug;163(2):466-480.
  4. Kuwada T, et al., Identification of an Anti-Integrin αvβ6 Autoantibody in Patients With Ulcerative Colitis. Gastroenterology. 2021 Jun;160(7):2383-2394.
  5. Maruno T, et al., Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging. Elife. 2021 Jan 4;10:e55117.


Professor:Hiroshi Seno
Associate Professor:Akihisa Fukuda, Norimitsu Uza
Assistant Professor:Shuji Yamamoto, Atsushi Takai, Mitsuhiro Nikaido, Tomoaki Matsumori,
Masahiro Shiokawa,Yuki Nakanishi, Haruhiko Takeda, Yoshihiro Nishikawa, Yu Muta


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