M.D., Ph.D. Professor Koh Ono
The Department of Cardiology at Kyoto University deals with diseases such as angina pectoris, myocardial infarction, valvular disease, heart failure, atherosclerosis, aneurysm, and arrhythmia. Due to the nature of the diseases and the large number of emergency cases, we strive to provide reliable cardiovascular care 24 hours a day. In our research, we aim to create new value originating from Kyoto for the world through analysis that incorporates a balance of basic and clinical approaches.
Research and Education
In basic research, we conduct highly original, world-leading research using new research methods that apply molecular biology, physiology, and genetics to solve questions obtained in clinical practice. Specifically, our research includes physiological functions of the heart and blood vessels, investigations into the pathogenesis of diseases, development of preventive and diagnostic methods, and translational research aimed at the development of therapeutic methods. We are eager to have young researchers and people from different fields participate in our research. In clinical research, we promote research that builds clinical evidence. Large-scale multicenter trials are underway in collaboration with many affiliated hospitals. We have also established a course for young physicians to learn statistical methods in depth. For more information on the specifics of ongoing research, please visit the Department’s home page.
Group photo of department members
Recent Publications
- Tsuji S, Otani C, Horie T, Watanabe S, Baba O, Sowa N, Ide Y, Kashiwa A, Makiyama T, Imai H, Nakashima Y, Yamasaki T, Xu S, Matsushita K, Suzuki K, Zou F, Kume E, Hasegawa K, Kimura T, Kakizuka A, Ono K. KUS121, a VCP modulator, has an ameliorating effect on acute and chronic heart failure without calcium loading via maintenance of intracellular ATP levels. Biomed Pharmacother.2024 Jan;170:115850. doi: 10.1016/j.biopha.2023.115850. Epub 2023 Dec 12. PMID: 38091636
- Miyagawa S, Horie T, Nishino T, Koyama S, Watanabe T, Baba O, Yamasaki T, Sowa N, Otani C, Matsushita K, Kojima H, Kimura M, Nakashima Y, Obika S, Kasahara Y, Kotera J, Oka K, Fujita R, Sasaki T, Takemiya A, Hasegawa K, Kimura T, Ono K. Inhibition of microRNA-33b in humanized mice ameliorates nonalcoholic steatohepatitis. Life Sci Alliance. 2023 Jun 1;6(8):e202301902. doi: 10.26508/lsa.202301902. PMID: 37263777; PMCID: PMC10235800.
- Yamasaki T, Horie T, Koyama S, Nakao T, Baba O, Kimura M, Sowa N, Sakamoto K, Yamazaki K, Obika S, Kasahara Y, Kotera J, Oka K, Fujita R, Sasaki T, Takemiya A, Hasegawa K, Minatoya K, Kimura T, Ono K. Inhibition of microRNA-33b specifically ameliorates abdominal aortic aneurysm formation via suppression of inflammatory pathways. Sci Rep. 2022 Jul 14;12(1):11984. doi: 10.1038/s41598-022-16017-5. PMID: 35835906 Free PMC article.
- Horie T, Nakao T, Miyasaka Y, Nishino T, Matsumura S, Nakazeki F, Ide Y, Kimura M, Tsuji S, Ruiz Rodriguez R, WatanabeT, Yamasaki T, Xu S, Otani C, Miyagawa S, Matsushita K, Sowa N, Omori A, Tanaka J, Nishimura C, Nishiga M, Kuwabara Y, Baba O, Watanabe S, Nishi H, NakashimaY, Picciotto MR, Inoue H, Watanabe D, Nakamura K, Sasaki T, Kimura T, Ono K. MicroRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity.Nature Communications 2021 Feb 16;12(1):843. doi: 10.1038/s41467-021-21107-5.
- Kuwabara Y, Tsuji S, Nishiga M, Izuhara M, Ito S, Nagao K, Horie T, Watanabe S, Koyama S, Kiryu H, Nakashima Y, Baba O, Nakao T, Nishino T, Sowa N, Miyasaka Y, Hatani T, Ide Y, Nakazeki F, Kimura M, Yoshida Y, Inada T, Kimura T, Ono K. Lionheart LincRNA alleviates cardiac systolic dysfunction under pressure overload. Commun Biol. 2020 Aug 13;3(1):434. doi: 10.1038/s42003-020-01164-0. PMID: 32792557
Laboratory
Staff Members
［Professor］Koh Ono
［Associate Professor］Takahiro Horie
［Junior Associate Professor］Satoshi Shizuta
［Assistant Professor］Shin Watanabe, Kazuya Nagao, Kyohei Yamaji, Hiroki Shiomi, Yugo Yamashita
［Program-Specific Assistant Professor, University Hospital］Kenji Nakatsuma, Yuta Tsujisaka
［Program-Specific Associate Professor (Department of Community Medicine Supporting System)］Hideyuki Kinoshita
［Program-Specific Senior Lecturer (Department of Community Medicine Supporting System)］Takeru Makiyama
［Associate Professor Institute of Advancement of Clinical and Translational Science Department of Clinical Research Facilitation Kyoto University Hospital］Takao Kato
［Assistant Professor Institute for Advancement of Clinical and Translational Science (iACT)］Erika Yamamotob
［Assistant Professor (Hospital – Clinical Laboratory)］Shushi Nishiwaki
［Preemptive Medicine and Lifestyle Disease Research Center Program-Specific Senior Lecturer］Osamu Baba、Eri Kato
TEL：+81-75-751-4254
FAX：+81-75-751-3289
e-mail：junkan@kuhp.kyoto-u.ac.jp
URL：https://cardio.kuhp.kyoto-u.ac.jp/