M.D., Ph.D. Professor Seishi Ogawa
Generally, any disease is resulted from individual genetic background and environmental effects, which are remarkably associated with genomic heterogeneity of human beings. This means that the alterations of specific genes play an important role in the environmental reactions leading to each disease. For the understanding and overcoming such diseases, it is essential to investigate the molecular mechanisms of mutual relations between the genetic factors and environment. We focus our study on the clarification of genetic significance and consequences in various neoplasms.
Research and Education
It is true that “genetic defects cause cancers.” However, it is more complicated and difficult to fully understand cancers than implied by such a simple statement. Cancer is consisted of the genetically heterogeneous multiple cells which are derived from cancer stem cells acquiring somatic mutations during the sequential divisions. Recently, the advanced sequencing technologies help us to identify a huge amount of new genetic abnormalities. However, it is still remain to be elucidated how the functional relevance of these genetic events, especially, the clonal selections of cancer cells escaping form the immunogenic reactions establishes the malignant characteristics with genetic heterogeneity.
For the breakthrough of cancer genetics and pathology, we would like to widely recruit motivated young researchers, who are interested in our field. We most welcome the applications from those who have academic backgrounds of various expertise for instance, bioinformatics, advanced genomics, and molecular cell biology, irrespective of medical or clinical experiences. Our mission is to foster excellent researchers who will be well-known and highly appreciated across the globe.
- Kataoka K, Shiraishi Y, Takeda Y, Sakata S, Matsumoto M, Nagano S, Maeda T, Nagata Y, Kitanaka A, Mizuno S, Tanaka H, Chiba K, Ito S, Watatani Y, Kakiuchi N, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Itonaga H, Imaizumi Y, Totoki Y, Munakata W, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Masuda K, Minato N, Kashiwase K, Izutsu K, Takaori-Kondo A, Miyazaki Y, Takahashi S, Shibata T, Kawamoto H, Akatsuka Y, Shimoda K, Takeuchi K, Seya T, Miyano S, Ogawa S. Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers. Nature;534:402-406 2016.
- Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S.N Engl J Med;373:35-47 2015.
- Sato Y, Maekawa S, Ishii R, Sanada M, Morikawa T, Shiraishi Y, Yoshida K, Nagata Y, Sato-Otsubo A, Yoshizato T, Suzuki H, Shiozawa Y, Kataoka K, Kon A, Aoki K, Chiba K, Tanaka H, Kume H, Miyano S, Fukayama M, Nureki O, Homma Y, Ogawa S. Recurrent somatic mutations underlie corticotropin-independent Cushing’s syndrome. Science;344:917-920 2014.
- Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki S, Sugano S, Haferlach C, Koeffler HP, Shih LY, Haferlach T, Chiba S, Nakauchi H, Miyano S, Ogawa S. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature;478:64-69 2011.
- Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S. Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature;460:904-908 2009.
Seishi Ogawa M.D., Ph.D. Professor
Hideki Makishima M.D., Ph.D., F.A.C.P. Associate professor
Yasuhito Nannya M.D., Ph.D. Program-Specific Associate Professor
Tetuichi Yoshizato M.D., Ph.D. Assistant Professor
Ayana Kon M.D., Ph.D. Assistant Professor
Akinori Yoda M.D., Ph.D. Program-Specific Assistant Professor
Department of Pathology and Tumor biology, Kyoto University
F-building, Yoshidakonoecho, Sakyo-ku, Kyoto, 606-8315, Japan