Associate Professor Kentaro Ibuki
Our research aims to elucidate the virus-host interactions involved in viral infection and pathogenicity. Unlike other microorganisms such as bacteria and fungi, viruses cannot grow without utilizing the functions of the host cell. Therefore, we believe that understanding the relationship between virus growth and host cell functions will lead to elucidation of the pathogenesis mechanism. Currently, we are focusing on the growth mechanisms and pathogenesis of mosquito-borne viruses and HIV.
Research and Education
Our group is currently working on the following research themes to understand the relationship between virus pathogenicity and host cell functions.
- Mosquito-borne viruses
・Effects of competitive proliferation of multiple mosquito-borne viruses on virus pathogenicity (Fig.1).
・Elucidation of the mechanism of inhibition of mosquito-borne virus proliferation by symbiotic bacteria and insect-specific viruses. - Primate immunodeficiency viruses
・Understanding the pathological mechanism of the virus and effective protective immunity using an experimental system of Simianized-mice (Fig.2).
・Understanding the mechanism of spread and proliferation of the virus during the acute phase of infection, focusing on dendritic cells and macrophages. - Extracellular vesicles (EVs)
・Effect of EVs obtained from plants on the human immune system.
In our group, each graduate student works on their own research topic and acquires skills and knowledge in virology, immunology, and cell biology.
Publications
- Matsuyama-Murata M, Inaba K, Horiuchi R, Fukazawa Y, Ibuki K et al. (2013) Genetic similarity of circulating and small intestinal virus at the end stage of acute pathogenic simian-human immunodeficieny virus infection. Front Microbiol 4:204.
- Himeno A, Akagi T, Uto T, Wang X, Baba M, Ibuki K et al. (2010) Evaluation of the immune response and protective effects of rhesus macaques vaccinated with biodegradable nanoparticles carrying gp120 of human immunodeficiency virus. Vaccine 28(32) 5377-5385.
- Matsuda K, Inaba K, Fukazawa Y, Matsuyama M, Ibuki K et al. (2010) In vivo analysis of a new R5 tropic SHIV generated from the highly pathogenic SHIV-KS661, a derivative of SHIV-89.6. Virology 399(1) 134-143.
- Inaba K, Fukazawa Y, Matsuda K, Himeno A, Matsuyama M, Ibuki K et al. (2010) Small intestine CD4+ cell reduction and enteropathy in simian/human immunodeficiency virus KS661-infected rhesus macaques in the presence of low viral load. J.Gen.Virol. 91(Pt3) 773-781.
- Yamamoto H, Li TC, Koshimoto C, Ito K, Kita M, Miyashita N, Arikawa J, Yagami K, Asano M, Tezuka H, Suzuki N, Kurosawa T, Shibahara T, Furuya M, Mohri S, Sato H, Ohsawa K, Ibuki K, Takeda N. (2008) Serological evidence for hepatitis E virus infection in laboratory monkeys and pigs in animal facilities in Japan. Exp. Anim. 57(4) 367-376.
Laboratory
Associate Professor：Kentaro Ibuki
Tel：+81-75-751-4178
FAX:+81-75-751-4178
e-mail：Ibuki.kentaro.7s@kyoto-u.ac.jp