Ph.D. Professor Yoko Hamazaki
The immune system protects our bodies against infectious pathogens. It is also responsible for immune rejection that occurs when organs are transplanted into a human body and is involved in the onset and pathology of various age-related diseases including cancers and lifestyle diseases. We will strive to explore the fundamental principles of immunology and develop strategies for controlling immune reactions in order to advance medicine and medical applications, especially focusing on T cell and thymus biology.
Research and Education
Our research themes:
Development and functions of supporting cells for lymphohematopoietic tissues such as thymic epithelial cells, which play a central role in the differentiation and selection of T cells.
- Induction of thymic epithelial cells from iPS cells and reconstruction of thymic functions.
- Mechanisms of thymic involution and activation of thymic functions.
- Mechanisms of immunosenescence and its association with age-related diseases.
- Regulation of the human immune system.
Ａ）Medullary thymic epithelial cells crucial for central tolerance induction
Ｂ）A Colony derived from thymic epithelial stem cells
Laboratory members
Recent Publications
- Booster COVID-19 mRNA vaccination ameliorates impaired B-cell but not T-cell responses in older adults
Kometani K, Yorimitsu T, Jo N, Yamaguchi E, Kikuchi O, Fukahori M, Sawada T, Tsujimoto Y, Sunami A, Li M, Ito T, Pretemer Y, Gao Y, Hidaka Y, Yamamoto M, Kaku N, Nakagama Y, Kido Y, Grifoni A, Sette A, Nagao M, Morita S, Nakajima TE, Muto M and Hamazaki Y Front. Immunol. 15:1455334. doi: 10.3389/fimmu.2024.1455334（2024） - Jo N, Hidaka Y, Kikuchi O, Fukahori M, Sawada T, Aoki M, Yamamoto M, Nagao M, Morita S, Nakajima TE, Muto M, Hamazaki Y✝. Impaired CD4+ T cell response in older adults is associated with reduced immunogenicity and reactogenicity of mRNA COVID-19 vaccination. Nat Aging. 2023 Jan;3(1):82-92.✝Correspondence
- Hamazaki Y✝, Sekai M, Minato N. Medullary thymic epithelial stem cells: role in thymic epithelial cell maintenance and thymic involution. Immunol Rev. 2016 May;271(1):38-55. ✝Correspondence
- Sekai M, Hamazaki Y✝, Minato N. Medullary thymic epithelial stem cells maintain a functional thymus 4to ensure lifelong central T cell tolerance. Immunity. 2014 Nov 14: 41(5), 753–761. ✝Correspondence
- Hamazaki Y, Fujita H, Kobayashi T, Choi Y, Scott HS, Matsumoto M, Minato N. Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin. Nat. Immunol. 2007 Mar; 8(3):304-11.
Laboratory
Professor：Yoko Hamazaki