Diagnostic PathologyMedicine and Medical Science

M.D. Professor Hironori Haga

Diagnostic pathology is a medical specialty aiming the diagnosis of diseases, based mainly on light microscopic examination of tissues or cells. Although most of our study focuses on histomorphology based on formalin-fixed, paraffin-embedded tissues, it always needs integration of molecular tests and clinicopathologic correlation. Techniques of immunohistochemistry and in situ hybridization are rapidly improving and allowing us to understand the mechanisms of diseases and to decide how to treat the patients.

Lab Website

Research and Education

Current research fields include 1) lung cancer, 2) pathology of signal transduction, and other clinicopathologic studies of various organs. We have contributed to validation of the current WHO classification of lung adenocarcinoma; Elucidation of roles of inhibitory receptors in tumor cells is another theme of our study and can be closely related to treatment of the patients. For clinicopathologic studies, in-house diagnostic database, image analysis using virtual microscopy, and tissue microarray technique are also available.

1:Expression of GATA-binding factor 6 (GATA6) and prognosis of lung cancer

2:Loss of killer immunoglobulin-like receptor (KIR) 2DL4 in the placenta is associated with infertility

Recent Publications

  1. Ito H, Yoshizawa A, Terada K, Nakakura A, Rokutan-Kurata M, Sugimoto T, Nishimura K, Nakajima N, Sumiyoshi S, Hamaji M, Menju T, Date H, Morita S, Bise R, Haga H. Deep learning-based assay for programmed death ligand 1 immunohistochemistry scoring in non-small cell lung carcinoma: Does it help pathologists score? Mod Pathol. 2024 Apr 6. Online ahead of print.
  2. Saka M, Fujimoto M, Mizoguchi K, Tsujimura M, Saeki M, Hirata M, Shibuya S, Odani K, Sakurai T, Yuba Y, Moriyoshi K, Nakajima N, Sumiyoshi S, Kono F, Ono K, Shirase T, Watanabe C, Yoshizawa A, Haga H. Insulin-like Growth Factor II mRNA-binding Protein 3 is a Highly Sensitive Marker for Intravascular Large B-cell Lymphoma: Immunohistochemical Analysis of 152 Pathology Specimens From 88 Patients. Am J Surg Pathol. 2024 Mar 18. Online ahead of print.
  3. Katsuragawa H, Sumiyoshi S, Ikegami N, Hashimoto S, Hajiro T, Taguchi Y, Kobashi Y, Haga H, Yoshizawa A. Histopathological significance of connective tissue disease-associated interstitial lung disease in transbronchial lung cryobiopsy specimens. Pathol Res Pract. 2024 Jan 2. Online ahead of print.
  4. Nakagawa R, Minamiguchi S, Kataoka TR, Fujikura J, Masui T, Fujimoto M, Yamada Y, Takeuchi Y, Teramoto Y, Ito H, Saka M, Kitamura K, Otsuki S, Nishijima R, Haga H. Circularity of islets is a distinct marker for the pathological diagnosis of adult non-neoplastic hyperinsulinemic hypoglycemia using surgical specimens. Diagn Pathol. 2023;18:115.
  5. Hirata M, Kogame T, Adachi S, Haga H. Galactosidase-catalyzed fluorescence amplification method (GAFAM): sensitive fluorescent immunohistochemistry using novel fluorogenic β-galactosidase substrates and its application in multiplex immunostaining. Histochem Cell Biol. 2023;159:233-246.


Professor Hironori Haga
Associate professor Sachiko Minamiguchi,Masakazu Fujimoto
Assistant professor Yasuhide Takeuchi,Yuki Teramoto,Hiroaki Ito,Kentaro Tsuji, Yoshiki Iemura

TEL +81-75-751-4946
FAX +81-75-751-4948
e-mail pathology@kuhp.kyoto-u.ac.jp
URL https://byori.kuhp.kyoto-u.ac.jp

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