M.D., Ph.D. Professor Hiroshi Date
The Department of Thoracic Surgery was founded in 1941 and has evolved from one of the earliest programs of its kind in Japan into a leading international thoracic surgery program. Video-assisted thoracoscopic surgery and robotic-assisted surgery have become standard approaches in our department for lung cancer surgery. Our lung transplant program has become the most active one in Japan, having performed 368 lung transplants to date. Thoracic surgeons trained in our department perform over 9,000 cases of thoracic surgery annually in affiliated hospitals, accounting for about 10% of all cases in Japan.
Research and Education
Faculty research within the Department of Thoracic Surgery covers a wide range of interests, including lung cancer, lung transplantation, and regenerative medicine. For lung cancer research, we are investigating prognostic factors following lung cancer surgery using specimens removed in the operating room. Recently, the EMT (epithelial-mesenchymal transition) mechanism has been extensively studied in our laboratory. We have developed an RFID (radiofrequency identification) system that can be used to localize undetectable small lung nodules, successfully utilized in over 200 patients. For lung transplant research, we have developed the ET-Kyoto solution for preservation, which is now clinically used in various institutions. We are also conducting studies on lung transplantation using donors after cardiac death, employing an ex-vivo lung perfusion animal model. We were the first in the world to successfully perform an inverted lobar lung transplantation, ABO blood type incompatible transplant, and combined lung and liver transplant. The Department of Thoracic Surgery provides education and treatment for a full range of complex general thoracic problems, including diagnoses, examinations, and both surgical and non-surgical therapies.
Stuff surgeons in Thoracic Surgery
①Lung transplantation research research ②Immunological research ③Cancer research ④Artificial trachea research
Recent Publications
- Date H. Living-donor lobar lung transplantation. J Heart Lung Transplant. 2024 Jan;43(1):162-168. doi: 10.1016/j.healun.2023.09.006. Epub 2023 Sep 11. PMID: 37704161
- Mineura K, Tanaka S, Goda Y, Terada Y, Yoshizawa A, Umemura K, Sato A, Yamada Y, Yutaka Y, Ohsumi A, Nakajima D, Hamaji M, Menju T, Kreisel D, Date H. Fibrotic progression from acute cellular rejection is dependent on secondary lymphoid organs in a mouse model of chronic lung allograft dysfunction. Am J Transplant. 2024 Feb 23:S1600-6135(24)00162-X. doi: 10.1016/j.ajt.2024.02.020. Online ahead of print. PMID: 38403187
- Murata Y, Yutaka Y, Hirata R, Hidaka Y, Hamaji M, Yoshizawa A, Kishimoto Y, Omori K, Date H. Development of novel layered polyglycolic acid sheet for regeneration of critical-size defect in rat trachea. Eur J Cardiothorac Surg. 2023 May 2;63(5). doi: 10.1093/ejcts/ezad159. PMID: 37097899
- Yutaka Y, Sato T, Hidaka Y, Kato T, Kayawake H, Tanaka S, Yamada Y, Ohsumi A, Nakajima D, Hamaji M, Menju T, Date H. Electromagnetic navigation bronchoscopy-guided radiofrequency identification marking in wedge resection for fluoroscopically invisible small lung lesions. Eur J Cardiothorac Surg. 2022 Dec 2;63(1):ezad006. doi: 10.1093/ejcts/ezad006. PMID: 36617166
- Nishikawa S, Menju T, Takahashi K, Miyata R, Chen-Yoshikawa TF, Sonobe M, Yoshizawa A, Sabe H, Sato T, Date H. Statins may have double-edged effects in patients with lung adenocarcinoma after lung resection. Cancer Manag Res 11:3419-32, 2019.
Laboratory
Professor: Hiroshi Date
Associate Professor: Toshi Menju
Lecturer: Daisuke Nakajima, Yojiro Yutaka
Assistant Professor: Satona Tanaka, Ryota Sumitomo, Shigeto Nishikawa, Hidenao Kayawake
Program Specific Assistant Professor, University hospital: Ichiro Sakanoue
TEL: +81-75-751-4975
FAX: +81-75-751-4974
E-mail: thoracic@kuhp.kyoto-u.ac.jp
URL: https://thoracic.kuhp.kyoto-u.ac.jp/