M.D., Ph.D. Professor Takashi Kobayashi
We have been dedicated to the development of novel treatment strategies and technologies in the fields of malignant diseases (prostatic cancer, renal cancer, urinary epithelial cancer, testicular cancer, etc.), kidney transplantation, and minimally invasive surgeries.
Through the close collaboration with our high-volume clinical department and basic research department, we conduct both translational researches on clinically unmet needs and biological researches on fundamental life science. in a well-balanced manner. We believe that this approach enables us to develop highly trained urological professionals who harbor the scientific and academic perspectives, which are essential abilities for Surgeon-scientists.
Research and Education
About 15 graduate students are engaged in our research laboratory at the Department of Urology, Kyoto University Graduate School of Medicine. Our research themes cover a wide range of topics such as uro-oncology, kidney transplantation, surgical techniques, and physiology of the urinary tract. We have been trying to elucidate the clinical questions and molecular mechanisms in these research fields using novel technologies such as next-generation sequencing, cell analysis, mouse models, and computer science. One of our strengths is that we have abundant clinical specimens (blood, urine, tumor tissue, etc.) obtained with the cooperation of patients at University Hospital and affiliated hospitals. Particularly, research using patient-derived xenograft (PDX) is one of the world’s leading fields in our department with a number of publications of original research and review articles. Although we are aware that research does not always work as we expected and can sometimes be painful, we are engaged in daily research with the motto of sharing the joy of revealing formerly unpreceded problems by original ingenuity.
Experiment using urological cancer cell lines
Basic research using clinical materials
Recent Publications
- Takeda M, Sakamoto H, Shibasaki N, Fukui T, Magaribuchi T, Sumiyoshi T, Utsunomiya N, Sawada A, Goto T, Kobayashi T, Ueda K, Yamasaki T, Ogawa O, Akamatsu S. Extracellular vesicles secreted from bone metastatic renal cell carcinoma promote angiogenesis and endothelial gap formation in bone marrow in a time-dependent manner in a preclinical mouse model. Front Oncol. 2023 Mar 23;13:1139049. doi: 10.3389/fonc.2023.1139049. eCollection 2023.
- Kono J, Ueda M, Sengiku A, Suadicani SO, Woo JT, Kobayashi T, Ogawa O, Negoro H. Flavonoid Nobiletin Attenuates Cyclophosphamide-Induced Cystitis in Mice through Mechanisms That Involve Inhibition of IL-1β Induced Connexin 43 Upregulation and Gap Junction Communication in Urothelial Cells. Int J Mol Sci. 2022 May 1;23(9):5037. doi: 10.3390/ijms23095037. PMID: 35563427
- Makino Y, Kamiyama Y, Brown JB, Tanaka T, Murakami R, Teramoto Y, Goto T, Akamatsu S, Terada N, Inoue T, Kodama T, Ogawa O, Kobayashi T. Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1. Commun Biol. 2022 Apr 1;5(1):299. doi: 10.1038/s42003-022-03227-w. PMID: 35365763
- Mizuno K, Sumiyoshi T, Okegawa T, Terada N, Ishitoya S, Miyazaki Y, Kojima T, Katayama H, Fujimoto N, Hatakeyama S, Shiota M, Yoshimura K, Matsui Y, Narita S, Matsumoto H, Kurahashi R, Kanno H, Ito K, Kimura H, Kamiyama Y, Sunada T, Goto T, Kobayashi T, Yamada H, Tsuchiya N, Kamba T, Matsuyama H, Habuchi T, Eto M, Ohyama C, Ito A, Nishiyama H, Okuno H, Kamoto T, Fujimoto A, Ogawa O, Akamatsu S. Clinical Impact of Detecting Low-Frequency Variants in Cell-Free DNA on Treatment of Castration-Resistant Prostate Cancer. Clin Cancer Res. 2021 Nov 15;27(22):6164-6173. doi: 10.1158/1078-0432.CCR-21-2328. Epub 2021 Sep 15. PMID: 34526361
- Kita Y, Hamada A, Saito R, Teramoto Y, Tanaka R, Takano K, Nakayama K, Murakami K, Matsumoto K, Akamatsu S, Yamasaki T, Inoue T, Tabata Y, Okuno Y, Ogawa O, Kobayashi T. Systematic chemical screening identifies disulfiram as a repurposed drug that enhances sensitivity to cisplatin in bladder cancer: a summary of preclinical studies. Br J Cancer. 2019 Dec;121(12):1027-1038. doi: 10.1038/s41416-019-0609-0. Epub 2019 Nov 1. PMID: 31673101 Free PMC article.
Laboratory
Professor: Takashi Kobayashi
Associate Professor: Ryoichi Saito
Senior Lecturer: Takayuki Goto
Assistant Professor: Kimihiko Masui・Yuki Kita・Takayuki Sumiyoshi・Jin Kono・Kaoru Murakami・Masashi Takeda・Takuro Sunada・Hajime Takamori
e-mail:uro＊kuhp.kyoto-u.ac.jp Please change ＊ to @ and send us an email.
URL:http://www.urology.kuhp.kyoto-u.ac.jp/