M.D., Ph.D. Professor Masaki Mandai
In the clinical field of obstetrics and gynecology, we manage physiological and psychological problems during the entire women’s life. In addition, obstetricians and gynecologists manage specialized field of pathophysiology; i.e. pregnancy and disease of female pelvic organs. In our department of gynecology and obstetrics, all postgraduate residents can learn characteristics of female pathophysiology, and can acquire basic knowledge about primary care in obstetric and gynecological emergency. In the research field, obstetrics and gynecology contain various research issues such as perinatology, gynelocogical oncology and reproductive pathophysiology.
Research and Education
Our department has four clinical/research (oncology, perinatology, reproduction medicine, health care). In oncology unit, we promote to perform minimally invasive surgery (laparoscopic and robotic) for all gynecologic disease. By omics analysis, we elucidate the tumor immunosuppressive mechanism, and investigate new tool of cancer-health care including dietary interventions in gynecologic malignancies. The perinatal lab investigates the repairing mechanism of ruptured fetal membranes, and isolation, culture, and functional analysis of villous stem cells from early pregnancy and full-term placenta using iPS cells. In reproduction unit, we perform immunotherapy using autologous PBMC for recurrent implantation failure, PGT-A, and oncofertility treatment for child and AYA patients. We clarify the mechanism of embryo implantation, development of immature oocyte, and improvement of embryo culture environment. In health care unit, we are developing an evidence-based smartphone application for self-rating of menstruation-associated symptoms which enables appropriate diagnosis for premenstrual disorders. We also perform fMRI study to investigate the mechanism of emotional symptoms relating to menstruation.
Recent Publications
- Suzuki H, Hamada K, Hamanishi J, Ueda A, Murakami R, Taki M, Mizuno R, Watanabe K, Sato H, Hosoe Y, Ito H, Yamanoi K, Yoshitomi H, Kakiuchi N, Yamaguchi K, Matsumura N, Ogawa S, Ueno H, Mandai M.
Artificial intelligence-based spatial analysis of tertiary lymphoid structures and clinical significance for endometrial cancer.
Cancer Immunol Immunother. 2025 Feb 1;74(3):84. doi: 10.1007/s00262-024-03929-6. PMID: 39891665 - Yasuda E, Kawamura Y, Ueda Y, Takakura M, Matsuzaka Y, Matsuzaka S, Inohaya A, Chigusa Y, Mandai M, Mogami H.
Potential mechanisms for chorioamniotic membrane rupture after subchorionic hematoma.
Am J Obstet Gynecol. 2025 Aug;233(2):125.e1-125.e18. doi: 10.1016/j.ajog.2025.01.031. Epub 2025 Jan 30.
PMID: 39892838 - Takakura M, Kawamura Y, Ueda Y, Matsuzaka S, Yasuda E, Matsuzaka Y, Inohaya A, Chigusa Y, Mandai M, Narumiya S, Yuhki KI, Mogami H.
Prostacyclin Assists in the Repair of Ruptured Amnions through the Proliferation and Migration of Amnion Mesenchymal Cells.
Am J Pathol. 2025 Oct;195(10):1808-1821. doi: 10.1016/j.ajpath.2025.06.002. Epub 2025 Jul 9.
PMID: 40645581 - Yusuke Sagae, Akihito Horie, Akihiro Yanai, Tsutomu Ohara, Baku Nakakita, Yoshimi Kitawaki, Asuka Okunomiya, Hirohiko Tani, Ken Yamaguchi, Junzo Hamanishi, John P. Lydon, Takiko Daikoku, Hideto Watanabe, Masaki Mandai. Versican provides the provisional matrix for uterine spiral artery dilation and fetal growth. Matrix Biol. 2023 Jan;115:16-31.
- Ohsuga, M. Egawa, Y. Takahashi, Y. Ikeda, K. Tsuyuki, K. Kanatani, F. Niwa, K. Hirabayashi, T. Nakayama, M. Mandai, The Japan Environment and Children’s Study Group. Association between low MCV in early pregnancy and perinatal mental health in the Japan Environment and Children’s Study and the possible effect of iron deficiency.
J Affect Disord.2024 Jul 1;356:34-40. PMID: 38583601
Laboratory
Professor : Masaki Mandai
Associate professor : Haruta Mogami
Junior Associate professor : Yoshitsugu Chigusa、Ryusuke Murakami、Koji Yamanoi
Assistant professor : Miho Egawa、Mana Taki 、Asuka Okunomiya、Masumi Sunada、Rin Mizuno
Program-Specific Junior Associate Professor : Ayaka Yamaguchi
Program-Specific Assistant Professor, University Hospital : Maya Komatsu、Yukiko Okada、Eriko Yausda、Tsutomu Ohara、Taito Miyamoto、Yosuke Kawamura、Takuma Oosuga、Akihiro Yanai
TEL ： +81-75-751-3269
FAX ： +81-75-761-3967
e-mail ： kuobgyn@kuhp.kyoto-u.ac.jp
URL ： http://www.kuhp.kyoto-u.ac.jp/~obgy/