M.D., Ph.D. Professor Kazutaka Obama
Our division performs highly precise minimally invasive surgery for gastrointestinal cancers, as well as benign diseases such as morbid obesity. To practice surgery that is truly beneficial to patients, we emphasize the process of resolving clinical questions scientifically, and plan and promote many clinical research projects. We also conduct basic research on the elucidation of the pathogenesis of gastrointestinal cancers and the development of new treatments, new medical technologies and surgical education systems. Through these research and clinical activities, we educate and train young surgeons with a broad perspective.
Research and Education
Major research interests are as follows; 1) molecular biological analysis of gastrointestinal carcinomas including stem cell biology, 2) physiological assessment of postoperative gastrointestinal function, 3) development of new imaging system to unveil and understand more detailed surgical anatomy, 4) development of novel surgical procedures and surgical instruments, 5) active involvement in the multi-institutional clinical trials to evaluate outcome of the surgical treatments. Endoscopic operations have provided the clear, magnified view even in the narrowest of the human body space and contributed to disclose the surgical anatomy. The precise recognition of surgical anatomy is absolutely mandatory to perform radical operations for cancers, avoiding neural damages and preserving functions. In addition, firm basic research will provide a scientific rationale for surgical therapy. A new surgical therapy must be further evaluated in well-designed clinical studies. It is critical for surgical trainees to study surgical science as well as to obtain a good surgical skill. We are confident that our program provides both of these in the finest quality.
Recent Publications
- Masui H, Kawada K, Itatani Y, et al. Synergistic antitumor activity by dual blockade of CCR1 and CXCR2 expressed on myeloid cells within the tumor microenvironment. Br J Cancer. 2024;131(1):63-76.
- Okamura R, Aoyama R, Tsunoda S, et al. Management challenges and the role of adjuvant chemotherapy in remnant gastric cancer: an analysis of 313 patients from the KEGG multicenter observational study. Gastric Cancer. 2024;27(6):1302-1310.
- Horita K, Hida K, Itatani Y, et al. Real-time detection of active bleeding in laparoscopic colectomy using artificial intelligence. Surg Endosc. 2024;38(6):3461-3469.
- Morimoto T, Takemura Y, Miura T, et al. Novel and efficient method for culturing patient-derived gastric cancer stem cells. Cancer Sci. 2023;114(8):3259-3269.
- Hanada K, Kawada K, Nishikawa G, et al. Dual blockade of macropinocytosis and asparagine bioavailability shows synergistic anti-tumor effects on KRAS-mutant colorectal cancer. Cancer Lett. 2021;522:129-141.
Laboratory
Professor: Kazutaka Obama
Associate Professor: Koya Hida
Senior Lecturer: Shigeru Tsunoda, Shigeo Hisamori
Program-Specific Senior Lecturer: Nobuaki Hoshino
Assistant Professor: Yoshiro Itatani, Tatsuto Nishigori, Ryosuke Okamura, Hisatsugu Maekawa, Keiko Kasahara, Shintaro Okumura, Takashi Sakamoto
TEL：+81-75-751-3650
FAX ：+81-75-751-3219
e-mail：060surg1@mail2.adm.kyoto-u.ac.jp
URL：https://gisurg.kuhp.kyoto-u.ac.jp/