Gastrointestinal SurgeryMedicine and Medical Science

M.D., Ph.D. Professor Kazutaka Obama

Our division performs highly precise minimally invasive surgery for gastrointestinal cancers, as well as benign diseases such as morbid obesity. To practice surgery that is truly beneficial to patients, we emphasize the process of resolving clinical questions scientifically, and plan and promote many clinical research projects. We also conduct basic research on the elucidation of the pathogenesis of gastrointestinal cancers and the development of new treatments, new medical technologies and surgical education systems. Through these research and clinical activities, we educate and train young surgeons with a broad perspective.

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Research and Education

Major research interests are as follows; 1) molecular biological analysis of gastrointestinal carcinomas including stem cell biology, 2) physiological assessment of postoperative gastrointestinal function, 3) development of new imaging system to unveil and understand more detailed surgical anatomy, 4) development of novel surgical procedures and surgical instruments, 5) active involvement in the multi-institutional clinical trials to evaluate outcome of the surgical treatments. Endoscopic operations have provided the clear, magnified view even in the narrowest of the human body space and contributed to disclose the surgical anatomy. The precise recognition of surgical anatomy is absolutely mandatory to perform radical operations for cancers, avoiding neural damages and preserving functions. In addition, firm basic research will provide a scientific rationale for surgical therapy. A new surgical therapy must be further evaluated in well-designed clinical studies. It is critical for surgical trainees to study surgical science as well as to obtain a good surgical skill. We are confident that our program provides both of these in the finest quality.

Recent Publications

  1. Shimoike N, Nishigori T, Yamashita Y, et al. Safety assessment of robotic gastrectomy and analysis of surgical learning process: a multicenter cohort study. Gastric Cancer. 2022 (in press).
  2. Okumura S, Konishi Y, Narukawa M, et al. Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion. Nat Commun. 2021;12:5674.
  3. Hanada K, Kawada K, Nishikawa G, et al. Dual blockade of macropinocytosis and asparagine bioavailability shows synergistic anti-tumor effects on KRAS-mutant colorectal cancer. Cancer Lett. 2021;522:129-141.
  4. Hisamori S, Okabe H, Tsunoda S, et al. Long-Term Outcomes of Laparoscopic Radical Gastrectomy for Highly Advanced Gastric Cancer: Final Report of a Prospective Phase II Trial (KUGC04). Ann Surg Oncol. 2021;28:8962-8972.
  5. Okada T, Hasegawa S, Nakamura T, et al. Precise three-dimensional morphology of the male anterior anorectum reconstructed from large serial histologic sections: A cadaveric study. Dis Colon Rectum. 2019;62(10):1238-1247.


Professor: Kazutaka Obama
Associate Professor: Koya Hida
Senior Lecturer: Shigeru Tsunoda
Program-specific Senior Lecturer: Nobuaki Hoshino
Assistant Professor: Shigeo Hisamori, Yoshiro Itatani, Tatsuto Nishigori, Ryosuke Okamura, Hisatsugu Maekawa, Keiko Kasahara, Shintaro Okumura

FAX :+81-75-751-3219

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