Research and Education

In our department, a wide variety of cancer researches are ongoing such as elucidating carcinogenic mechanisms, developing new diagnostic modality and anticancer treatments, and clinical application of precision medicine. We are particularly interested in elucidating the molecular-level carcinogenic mechanism of esophageal squamous cell carcinoma by alcohol, which leads to developing the new preventive methods of esophageal cancer. Regarding the treatments, we are developing new concepts-based curative cancer treatments using both immune checkpoint inhibitors and nonsurgical modalities in investigator-initiated clinical trials. We have shown remarkable presence for leading the precision medicine in Japan, and have conducted a multi-institutional clinical study of comprehensive genomic profiling in Advanced Medical Care. OncoNephrology, a new interdisciplinary academic area about pharmacology of chemotherapy and renal dysfunction, is one of our most focused research projects in collaboration with other clinical departments. We also have projects of translational researches contributing to the early clinical development and projects for consortium of new medical real-world data (RWD) platform. Graduate school students and senior residents in our department can choose their favorite fields of research and receive specialized education.

Group photo of classroom members

Recent Publications

1. Combination therapy with WEE1 inhibition and trifluridine/tipiracil against esophageal squamous cell carcinoma. Nguyen Vu TH, Kikuchi O, Ohashi S, Saito T, Ida T, Nakai Y, Cao Y, Yamamoto Y, Kondo Y, Mitani Y, Kataoka S, Kondo T, Katada C, Yamada A, Matsubara J, Muto M. Cancer Sci 2023 Dec;114(12):4664-4676. doi: 10.1111/cas.15966. Epub 2023 Sep 19.
2. First-Line Genomic Profiling in Previously Untreated Advanced Solid Tumors for Identification of Targeted Therapy Opportunities. Matsubara J, Mukai K, Kondo T, Yoshioka M, Kage H, Oda K, Kudo R, Ikeda S, Ebi H, Muro K, Hayashi R, Tokudome N, Yamamoto N, Muto M. JAMA Netw Open 2023 Jul 3;6(7):e2323336. doi: 10.1001/jamanetworkopen.2023.23336. PMID: 37459099
3. Norihide Jo, Yu Hidaka, Osamu Kikuchi, Masaru Fukahori, Takeshi Sawada, Masahiko Aoki, Masaki Yamamoto, Miki Nagao, Satoshi Morita, Takako E Nakajima, Manabu Muto, Yoko Hamazaki. Impaired CD4+ T cell response in older adults is associated with reduced immunogenicity and reactogenicity of mRNA COVID-19 vaccination. Nat Aging 2023 Jan;3(1):82-92. 　doi: 10.1038/s43587-022-00343-4.
4. Keiji Nihei, Keiko Minashi, Tomonori Yano, Tadakazu Shimoda, Haruhiko Fukuda, Manabu Muto. Final analysis of diagnostic endoscopic resection followed by selective chemoradiotherapy for stage I esophageal cancer: JCOG0508. Gastroenterology 2023 Feb;164(2):296-299.e2. doi: 10.1053/j.gastro.2022.10.002.
5. Yosuke Mitani,Shinya Ohashi,Osamu Kikuchi,Yukie Nakai,Tomomi Ida,Ayaka Mizumoto,Yoshihiro Yamamoto,Tomoki Saito,Shigeki Kataoka,Junichi Matsubara,Atsushi Yamada,Masashi Kanai,Shigemi Matsumoto,Hiroaki Sakai,Kiyotsugu Yoshikawa,Eijiro Nakamura,Manabu Muto. HER2 G776S Mutation Promotes Oncogenic Potential in Colorectal Cancer Cells when Accompanied by Loss of APC Function. Sci Rep 2022 Jun 2;12(1):9213.

Laboratory

Professor: Manabu Muto
Program-Specific Professor: Shigemi Matsumoto
Associate Professor: Junichi Matsubara
Program-Specific Associate Professor: Shinya Ohashi, Atsushi Yamada
Lecturer: Akira Yokoyama
Program-Specific Lecturer: Chikatoshi Katada, Ryo Sakamoto､Motoo Nomura, Yukiko Mori, Takahiro Horimatsu
Assistant Professor: Masahiro Yoshioka
Program-Specific Assistant Professor: Masashi Tamaoki, Nobuko Kawaguchi,
Specific Hospital Assistant Professor: Takashi Nomizo, Tomohiro Kondo

TEL ： +81-75-751-4592
FAX ： +81-75-751-4594
e-mail ： clinonc10thanniv@kuhp.kyoto-u.ac.jp
URL ： http://oncology.kuhp.kyoto-u.ac.jp