Research and Education

In our department, a wide variety of cancer researches are ongoing such as elucidating carcinogenic mechanisms, developing new diagnostic modality and anticancer treatments, and clinical application of precision medicine. We are particularly interested in elucidating the molecular-level carcinogenic mechanism of esophageal squamous cell carcinoma by alcohol, which leads to developing the new preventive methods of esophageal cancer. Regarding the treatments, we are developing new concepts-based curative cancer treatments using both immune checkpoint inhibitors and nonsurgical modalities in investigator-initiated clinical trials. We have shown remarkable presence for leading the precision medicine in Japan, and have conducted a multi-institutional clinical study of comprehensive genomic profiling in Advanced Medical Care. OncoNephrology, a new interdisciplinary academic area about pharmacology of chemotherapy and renal dysfunction, is one of our most focused research projects in collaboration with other clinical departments. We also have projects of translational researches contributing to the early clinical development and projects for consortium of new medical real-world data (RWD) platform. Graduate school students and senior residents in our department can choose their favorite fields of research and receive specialized education.

Group photo of classroom members

Recent Publications

1. Aldh2 and the tumor suppressor Trp53 play important roles in alcohol-induced squamous field cancerization. Kondo Y, Ohashi S, Katada C, Nakai Y, Yamamoto Y, Tamaoki M, Kikuchi O, Yamada A, Hirohashi K, Mitani Y, Kataoka S, Saito T, Nguyen Vu TH, Kondo T, Uneno Y, Sunami T, Yokoyama A, Matsubara J, Matsuda T, Naganuma S, Oryu K, Flashner S, Shimonosono M, Nakagawa H, Muto M. J Gastroenterol 2025 in press.
2. Organ-On-A-Chip Platforms Created Through Buckled Microchannels of Porous Hydrogel Films. Takahashi R, Tanaka A, Saito T, Ohashi S, Muto M, Yamaguchi M. Adv Mater Technol 2025 in press.
3. First-Line Genomic Profiling in Previously Untreated Advanced Solid Tumors for Identification of Targeted Therapy Opportunities. Matsubara J, Mukai K, Kondo T, Yoshioka M, Kage H, Oda K, Kudo R, Ikeda S, Ebi H, Muro K, Hayashi R, Tokudome N, Yamamoto N, Muto M. JAMA Netw Open 2023 Jul 3;6(7):e2323336. doi: 10.1001/jamanetworkopen.2023.23336. PMID: 37459099.
4. Combination therapy with WEE1 inhibition and trifluridine/tipiracil against esophageal squamous cell carcinoma. Nguyen Vu TH, Kikuchi O, Ohashi S, Saito T, Ida T, Nakai Y, Cao Y, Yamamoto Y, Kondo Y, Mitani Y, Kataoka S, Kondo T, Katada C, Yamada A, Matsubara J, Muto M. Cancer Sci 2023 Dec;114(12):4664-4676. doi: 10.1111/cas.15966.
5. Age-related remodelling of oesophageal epithelia by mutated cancer drivers. Yokoyama A, Kakiuchi N, Yoshizato T, Nannya Y, Suzuki H, Takeuchi Y, Shiozawa Y, Sato Y, Aoki K, Kim SK, Fujii Y, Yoshida K, Kataoka K, Nakagawa MM, Inoue Y, Hirano T, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Nishikawa Y, Amanuma Y, Ohashi S, Aoyama I, Horimatsu T, Miyamoto S, Tsunoda S, Sakai Y, Narahara M, Brown JB, Sato Y, Sawada G, Mimori K, Minamiguchi S, Haga H, Seno H, Miyano S, Makishima H, Muto M, Ogawa S. Nature 2019 Jan;565(7739):312-317. doi: 10.1038/s41586-018-0811-x.

Laboratory

Professor: Manabu Muto
Program-Specific Professor: Shigemi Matsumoto
Associate Professor: Junichi Matsubara
Program-Specific Associate Professor: Shinya Ohashi, Atsushi Yamada, Chikatoshi Katada
Lecturer: Akira Yokoyama
Program-Specific Lecturer: Ryo Sakamoto､Motoo Nomura, Yukiko Mori, Takahiro Horimatsu, Chang Liu
Assistant Professor: Masahiro Yoshioka
Program-Specific Assistant Professor: Masashi Tamaoki, Nobuko Kawaguchi, Tomohiro Kondo, Takashi Nomizo, Shigeki Kataoka

TEL ： +81-75-751-4592
FAX ： +81-75-751-4594
e-mail ： clinonc10thanniv@kuhp.kyoto-u.ac.jp
URL ： http://oncology.kuhp.kyoto-u.ac.jp