Research and education

Our laboratory conducts both basic and clinical research centered on the elucidation of the mechanisms of kidney repair. In basic research, we focus on the intriguing “phenomena” found in human kidney disease, and aim to elucidate the pathogenesis of these “phenomena” using genetically engineered mice, in vivo imaging, and state-of-the-art technologies such as single-cell analysis, and to develop therapeutic strategies that can be applied to human kidney disease. Specifically, we aim to (1) elucidate the mechanism of delayed repair in aged kidneys, (2) analyze the spatiotemporal energy dynamics o in kidney disease, and (3) identify the cells responsible for kidney repair. Ultimately, we aim to identify novel therapeutic targets for human kidney disease.
In clinical research, we are working on (1) onconephrology, which integrates oncology and nephrology, and (2) research using artificial intelligence and big data analysis.
Our department aims to nurture physician scientists with a deep understanding of the basic and clinical aspects of the disease, and who can elucidate their patient-oriented research questions by their own research skills.

Recent Publications

1. Keiichi Kaneko, Yuki Sato, EiichiroUchino, Naoya Toriu, Mayo Shigeta, Hiroshi Kiyonari, Shuichiro Endo, Sshingo Fukuma, Motoko Yanagita. “Lineage tracing analysis defines erythropoietin-producing cells as a distinct subpopulation of resident fibroblasts with unique behaviors” Kidney Int. 102(2): 280-292. doi: 10.1016/j-kinit. 2022.04.026. Epub 2022 May 27
2. Yuki Sato, Akiko Oguchi, Yuji Fukushima, Kyoko Masuda, Naoya Toriu, Keisuke Taniguchi, Takahisa Yoshikawa, Xiaotong Cui, Makiko Kondo, Takeshi Hosoi, Shota Komidori, Yoko Shimizu, Harumi Fujita, Li Jiang, Yingyi Kong, Takashi Yamanashi, Jun Seita, Takuya Yamamoto, Shinya Toyokuni, Yoko Hamazaki, Masakazu Hattori, Yasunobu Yoshikai, Peter Boor, Jurgen Floege, Hiroshi Kawamoto, Yasuhiro Murakawa, Nagahiro Minato, Motoko Yanagita. “CD153/CD30 signailing promotes age-dependent tertiary lymphoid tissue expansion and kidney injury” J Clin Invest. 2022 Jan 18;132(2):e146071. doi: 10.1172/JCI146071. PMID: 34813503
3. Yu Ho Lee, Yuki Sato, Mitsuru Saito, Shingo Fukuma, Masaya Saito, Shigenori Yamamoto, Atsushi Komatsuda, Nobuhiro Fujiyama, Shigeru Satoh, Sang-Ho Lee, Peter Boor, Tomonori Habuchi, Juergen Floege, Motoko Yanagita. “Advanced Tertiary Lymphoid Tissues in Protocol Biopsies are Associated with Progressive Graft Dysfunction in Kidney Transplant Recipients” J Am Soc Nephrol. 2022 Jan;33(1):186-200. doi: 10.1681/ASN.2021050715. Epub 2021 Nov 1. PMID: 34725107
4. Shinya Yamamoto, Masamichi Yamamoto, Jin Nakamura, Akiko Mii, Shigenori Yamamoto, Masahiro Takahashi, Keiichi Kaneko, Eiichiro Uchino, Yuki Sato, Shingo Fukuma, Hiromi Imamura, Michiyuki Matsuda, Motoko Yanagita “Spatiotemporal ATP dynamics during acute kidney injury predicts renal prognosis” Journal of the American Society of Nephrology　2020 Dec;31(12):2855-2869. doi: 10.1681/ASN.2020050580. Epub 2020 Oct 12. PMID:33046532
5. Yuki Sato, Peter Boor, Shingo Fukuma, Barbara M. Klinkhammer, Hironori Haga, Osamu Ogawa, Jürgen Floege and Motoko Yanagita. “Developmental stages of tertiary lymphoid tissue reflect local injury and inflammation in mouse and human kidneys” Kidney Int. 2020 Aug;98(2):448-463. doi: 10.1016/j.kint.2020.02.023. Epub 2020 May 28.PMID: 32473779

Laboratory

Professor: Motoko Yanagita
Senior Lecturer: Takeshi Matsubara, Hideki Yokoi
Assistant Professor: Kaoru Sakai, Shinya Yamamoto, Keiichi Kaneko
Specific Hospital Assistant Professor: Shigenori Yamamoto, Yuichiro Kitai, Sayaka Sugioka, Takahisa Yoshikawa
Program-Specific Assistant Professor (Department of Adaptive and Maladaptive Responses in Health and Disease): Ryo Yamada
Program-Specific Researcher (ASHBi): Naoya Toriu, Youngna Kan

TEL: +81 75-751-3860
FAX: +81 75-751-3859
e-mail: kidney2011@kuhp.kyoto-u.ac.jp
URL: http://www.kidney.kuhp.kyoto-u.ac.jp/