M.D., Ph.D. Professor Motoko Yanagita
Our department was established in 2011, based on the remarkable progress in nephrology and the increase in the number of patients with kidney diseases.
Our research goal is to understand the pathophysiology of kidney disease progression and to propose novel and effective therapeutic agents, and our clinical mission is to provide the highest level of treatment for the patients with kidney diseases and provide comprehensive care for their comorbidities.
We will educate young physicians to become physician scientists with advanced clinical and research skills that can contribute to nephrology.
Research and education
Our laboratory conducts both basic and clinical research centered on the elucidation of the regulatory mechanisms of kidney injury and repair. In basic research, we aim to elucidate the pathogenesis of kidney diseases using state-of-the-art technologies such as single-cell analysis, spatial transcriptomics, and live imaging. Specifically, we aim to (1) elucidate the mechanism of delayed repair in aged kidneys, (2) analyze the spatiotemporal dynamics of energy metabolism in kidney disease, and (3) identify the cells responsible for kidney repair. Ultimately, we aim to identify novel therapeutic targets for human kidney disease and establish therapeutic agents.
In clinical research, we are working on (1) onconephrology, which integrates oncology and nephrology, and (2) AI-based diagnosis and prediction of kidney diseases.
Our department aims to nurture physician scientists who can acquire a deep understanding of the basic and clinical aspects of the disease, and who can elucidate their patient-oriented research questions by their own research skills.
Recent Publications
- Akiko Oguchi, Akari Suzuki, Shuichiro Komatsu, Hiroyuki Yoshitomi, Shruti Bhagat, Raku Son, Raoul Jean Pierre Bonnal, Shohei Kojima, Masaru Koido, Kazuhiro Takeuchi, Keiko Myouzen, Gyo Inoue, Tomoya Hirai, Hiromi Sano, Yujiro Takegami, Ai Kanemaru, Itaru Yamaguchi, Yuki Ishikawa, Nao Tanaka, Shigeki Hirabayashi, Riyo Konishi, Sho Sekito, Takahiro Inoue, Juha Kere, Shunichi Takeda, Akifumi Takaori-Kondo, Itaru Endo, Shinpei Kawaoka, Hideya Kawaji, Kazuyoshi Ishigaki, Hideki Ueno, Yoshihide Hayashizaki, Massimiliano Pagani, Piero Carninci, Motoko Yanagita, ITEC consortium, Nicholas Parrish, Chikashi Terao, Kazuhiko Yamamoto, Yasuhiro Murakawa. “An atlas of transcribed enhancers across helper T cell diversity for decoding human diseases” Science. 2024 Jul 5, 385(6704):eadd8394. doi: 10.1126/acience.add8394. Epub 2024 Jul 5. PMID:38963856
- Shigenori Yamamoto, Shinya Yamamoto, Masahiro Takahashi, Akiko Mii, Akihiro Okubo, Naoya Toriu, Shunsaku Nakagawa, Takaaki Abe, Shingo Fukuma, Hiromi Imamura, Masamichi Yamamoto, Motoko Yanagita, “Visualization of intracellular ATP dynamics in different nephron segments under pathophysiological conditions using the kidney slice culture system” Kidney Int. 2024 Jul 3:S0085-2538(24)00409-5. Doi: 10.1016/j.kint.2024.05.028. Online ahead of print. PMID:38996810
- Takahisa Yoshikawa, Akiko Oguchi, Naoya Toriu, Yuki Sato, Takashi Kobayashi, Osamu Ogawa, Hironori Haga, Satoko Sakurai, Takuya Yamamoto, Yasuhiro Murakawa, Motoko Yanagita. “Tertiary Lymphoid Tissues Are Microenvironments with Intensive Interactions between Immune Cells and Proinflammatory Parenchymal Cells in Aged Kidneys. J Am Soc Nephrol” 2023 Oct 1;34(10):1687-1708. doi: 10.1681/ASN.0000000000000202. Epub 2023 Aug 7. PMID: 37548710; PMCID: PMC10561819.
- Keiichi Kaneko, Yuki Sato, Eiichiro Uchino, Naoya Toriu, Mayo Shigeta, Hiroshi Kiyonari, Shuichiro Endo, Shingo Fukuma, Motoko Yanagita. “Lineage tracing analysis defines erythropoietin-producing cells as a distinct subpopulation of resident fibroblasts with unique behaviors” Kidney Int. 2022 Aug;102(2):280-292. doi: 10.1016/j.kint.2022.04.026. Epub 2022 May 27. PMID: 35644281.
- Yuki Sato, Akiko Oguchi, Yuji Fukushima, Kyoko Masuda, Naoya Toriu, Keisuke Taniguchi, Takahisa Yoshikawa, Xiaotong Cui, Makiko Kondo, Takeshi Hosoi, Shota Komidori, Yoko Shimizu, Harumi Fujita, Li Jiang, Yingyi Kong, Takashi Yamanashi, Jun Seita, Takuya Yamamoto, Shinya Toyokuni, Yoko Hamazaki, Masakazu Hattori, Yasunobu Yoshikai, Peter Boor, Jurgen Floege, Hiroshi Kawamoto, Yasuhiro Murakawa, Nagahiro Minato, Motoko Yanagita. “CD153/CD30 signailing promotes age-dependent tertiary lymphoid tissue expansion and kidney injury” J Clin Invest. 2022 Jan 18;132(2):e146071. doi: 10.1172/JCI146071. PMID: 34813503
Laboratory
Professor：Motoko Yanagita
Lecturer： Shinya Yamamoto
Special Appointment Lecturer (Hospital) ：Keiichi Kaneko
Assistant Professor： Shigenori Yamamoto
Program-Specific Assistant Professor, University Hospital： Yuichiro Kitai, Sayaka Sugioka, Shoko Ohno, Masahiro Takahashi, Takahisa Yoshikawa
Program-Specific Assistant Professor (Department of Adaptive and Maladaptive Responses in Health and Disease)：Ryo Yamada
Program-Specific Researcher (ASHBi)：Naoya Toriu, Yohei Iwashige
Program-Specific Researcher (Collaborative Research with Boehringer Ingelheim International GmbH)：Keisuke Taniguchi
TEL: +81 75-751-3860
FAX: +81 75-751-3859
e-mail: kidney2011@kuhp.kyoto-u.ac.jp
URL: https://kidney.kuhp.kyoto-u.ac.jp/