M.D., Ph.D. Professor Motoko Yanagita
Our department was established in 2011, and its establishment is based on the remarkable progress in nephrology and the increase of patients with kidney disease in recent years.
Our research goal is to understand the pathophysiology of kidney disease and to propose effective therapeutic agents, and our clinical mission is to provide the highest level of treatment for kidney diseases and provide comprehensive care for the patients.
We will educate young physicians to become physician scientists with advanced clinical and research skills that can contribute to nephrology.
Research and education
Our laboratory conducts both basic and clinical research centered on the elucidation of the mechanisms of kidney repair. In basic research, we focus on the intriguing “phenomena” found in human kidney disease, and aim to elucidate the pathogenesis of these “phenomena” using genetically engineered mice, in vivo imaging, and state-of-the-art technologies such as single-cell analysis, and to develop therapeutic strategies that can be applied to human kidney disease. Specifically, we aim to (1) elucidate the mechanism of delayed repair in aged kidneys, (2) analyze the spatiotemporal energy dynamics o in kidney disease, and (3) identify the cells responsible for kidney repair. Ultimately, we aim to identify novel therapeutic targets for human kidney disease.
In clinical research, we are working on (1) onconephrology, which integrates oncology and nephrology, and (2) research using artificial intelligence and big data analysis.
Our department aims to nurture physician scientists with a deep understanding of the basic and clinical aspects of the disease, and who can elucidate their patient-oriented research questions by their own research skills.
Recent Publications
- Akiko Oguchi, Akari Suzuki, Shuichiro Komatsu, Hiroyuki Yoshitomi, Shruti Bhagat, Raku Son, Raoul Jean Pieer Bonnal, Shohei Kojima, Masaru Koido, Kazuhiro Takeuchi, Keiko Myouzen, Gyo Inoue, Tomoya Hirai, Hiromi Sano, Yujiro Takegami, Ai Kanemaru, Itaru Yamaguchi, Yuki Ishikawa, Nao Tanaka, Shigeki Hirabayashi, Riyo Konishi, Sho Sekito, Takahiro Inoue, Juha Kere, Shunichi Takeda, Akifumi Takaori-Kondo, Itaru Endo, Shinpei Kawaoka, Hideya Kawaji, Kazuyoshi Ishigaki, Hideki Ueno, Yoshihide Hayashizaki, Massimiliano Pagani, Piero Carninci, Motoko Yanagita; ITEC Consortium‡; Nicholas Parrish, Chikashi Terao, Kazuhiko Yamamoto, Yasuhiro Murakawa; ITEC Consortium Members. “An atlas of transcribed enhancers across helper T cell diversity for decoding human diseases” Science. 2024 Jul 5;385(6704):eadd8394. doi: 10.1126/science.add8394. Epub 2024 Jul 5. PMID: 38963856.
- Shigenori Yamamoto, Shinya Yamamoto, Masahiro Takahashi, Akiko Mii, Akihiro Okubo, Naoya Toriu, Shunsaku Nakagawa, Takaaki Abe, Shingo Fukuma, Hiromi Imamura, Masamichi Yamamoto, Motoko Yanagita. “Visualization of intracellular ATP dynamics in different nephron segments under pathophysiological conditions using the kidney slice culture system” Kidney Int. 2024 Sep;106(3):470-481. doi: 10.1016/j.kint.2024.05.028. Epub 2024 Jul 9. PMID: 38996810.
- Takahisa Yoshikawa, Akiko Oguchi, Naoya Toriu, Yuki Sato, Takashi Kobayashi, Osamu Ogawa, Hironori Haga, Satoko Sakurai, Takuya Yamamoto, Yasuhiro Murakawa, Motoko Yanagita. “Tertiary Lymphoid Tissues Are Microenvironments with Intensive Interactions between Immune Cells and Proinflammatory Parenchymal Cells in Aged Kidneys” J Am Soc Nephrol” 2023 Oct 1;34(10):1687-1708. doi: 10.1681/ASN.0000000000000202. Epub 2023 Aug 7. PMID: 37548710
- Keiichi Kaneko, Yuki Sato, EiichiroUchino, Naoya Toriu, Mayo Shigeta, Hiroshi Kiyonari, Shuichiro Endo, Sshingo Fukuma, Motoko Yanagita. “Lineage tracing analysis defines erythropoietin-producing cells as a distinct subpopulation of resident fibroblasts with unique behaviors” Kidney Int. 2022 Aug;102(2):280-292. doi: 10.1016/j.kint.2022.04.026. Epub 2022 May 27. PMID: 35644281.
- Yuki Sato, Akiko Oguchi, Yuji Fukushima, Kyoko Masuda, Naoya Toriu, Keisuke Taniguchi, Takahisa Yoshikawa, Xiaotong Cui, Makiko Kondo, Takeshi Hosoi, Shota Komidori, Yoko Shimizu, Harumi Fujita, Li Jiang, Yingyi Kong, Takashi Yamanashi, Jun Seita, Takuya Yamamoto, Shinya Toyokuni, Yoko Hamazaki, Masakazu Hattori, Yasunobu Yoshikai, Peter Boor, Jurgen Floege, Hiroshi Kawamoto, Yasuhiro Murakawa, Nagahiro Minato, Motoko Yanagita. “CD153/CD30 signailing promotes age-dependent tertiary lymphoid tissue expansion and kidney injury” J Clin Invest. 2022 Jan 18;132(2):e146071. doi: 10.1172/JCI146071. PMID: 34813503
Laboratory
Professor：Motoko Yanagita
Assistant Professor：Shinya Yamamoto, Keiichi Kaneko
Program-Specific Assistant Professor, University Hospital：Shigenori Yamamoto, Yuichiro Kitai, Sho Hasegawa, Kiyoka Sugioka, Takahisa Yoshikawa
Program-Specific Professor(Department of Adaptive and Maladaptive Responses in Health and Disease)：Ryo Yamada
Program-Specific Researcher：Keisuke Taniguchi
Program-Specific Researcher(ASHBi)：Naoya Toriu, Youngna Kang
TEL: +81 75-751-3860
FAX: +81 75-751-3859
e-mail: kidney2011@kuhp.kyoto-u.ac.jp
URL: http://www.kidney.kuhp.kyoto-u.ac.jp/