We conduct cutting-edge research in collaboration with industry and academia with the aim of treating intractable and rare diseases, with a focus on skin diseases or a molecular mechanism common to diseases. The skin is an organ that surrounds the entire body. Skin diseases are very diverse, including infectious diseases, autoimmune diseases, allergic diseases, drug eruptions, and tumors. The skin is visible to all and can be touched directly. The strength of direct access to organs is one of the strengths of modern dermatology. Skin biopsies, stratum corneum sampling by tape stripping, artificial blisters are used to safely collect diseased cells, to which cutting-edge analysis techniques are applied. In addition, we target ferroptosis, abnormal splicing, GPCR signaling, etc. as molecular mechanisms common to diseases. Utilizing the strengths of Kyoto University, we will continue to advocate new disease concepts through exchanges with different fields and contribute to a better world.