Drug Discovery Medicine


Narumiya, Shuh, M.D., Ph.D. Professor btn

At the Department of Drug Discovery Medicine, we work closely with supporting pharmaceutical companies and nurture people with talents required for drug discovery and development in a new era. We accept both medical graduates and graduates from other disciplines for our master’s and doctoral program. The goal of our curriculum is to make graduates ready to work in a wide variety of positions in drug discovery and development, including (not limited) researchers both in academia and pharmaceutical companies, entrepreneurs, managers in drug discovery and development, and managers in academia-pharma collaboration.

Research and Education


In Layer 1 of our program, lectures and laboratory courses will be provided for non-MD students to acquire systematic knowledge of core basic science in medicine. In Layer 2, all students further acquire essential knowledge in the current drug discovery and development such as clinical human genetics, bioinformatics, etc. and, in Layer 3, they participate in a series of seminars studying pathophysiology of human diseases and engaging in active discussion on target identification and development of new therapeutic modalities using several diseases as representative examples. Finally, in Layer 4, trainees are exposed to studies in wider areas related to drug discovery and development such as bio-bank, big data science, precision medicine, clinical trials, intellectual properties, regulatory science, and business models, all of which are important in filling gaps among academia, companies and society to facilitate delivery of drugs to the patients. In parallel with such educational course works, students conduct their own research projects by participating in academia-pharma collaborative projects ongoing at the Medical Innovation Center and other departments of Kyoto University.

Recent Publications

  1. Narumiya, S., Thumkeo, D, Rho signaling research: history, current status and future directions, FEBS Letters 592(11): 1763-1776, 2018
  2. Aoki, T. et al. (2017) Prostaglandin E2-EP2-NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms. Science Signaling, 10(465). pii: eaah6037.
  3. Deguchi, Y. et al.(2016) mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety. Cell Reports, 17, 2405-2417.
  4. SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells. Ohtsuki G, Piochon C, Adelman JP, Hansel C. Neuron, Volume 75, Issue 1, 108-120; 12 Jul 2012, doi: 10.1016/j.neuron.2012.05.025
  5. Honda, M., Oki, S., et al. High resolution spatial transcriptome analysis by photo-isolation chemistry. BioRxiv, 2020.

Drug Discovery Medicine

Professor and Chair: Narumiya, Shuh
Professor: Ohtsuki, Gen
Professor: Saotome, Chikako
Associate Professor: Thumkeo, Dean
Associate Professor: Oki, Shinya
Assistant Professor: Ajiro, Masahiko
TEL:075-366-7417
FAX:075-762-1884
MAIL:contact@ddm.med.kyoto-u.ac.jp
URL:http://www.mic.med.kyoto-u.ac.jp/dddm_en/