Theoretical Cell Science

kao Wataru Fujibuchi, Ph.D. Professor   btn

As the first informatics laboratory at CiRA, we are engaging in 1) spatio-temporal analysis of cell differentiations to construct fundamental theories, 2) design of 3D tissues derived from iPS cells by single-cell analysis, 3) development of a human cell database and its medical application, and 4) establishment of drug screening system for cell therapy based on artificial intelligence.  To enhance quality control of engineered cells, we are further developing a reference database of all human cell types at single-cell levels. Using this database, we will construct a “cell periodic table” with which we will theoretically find unknown cell types or elucidate the natural history of cell type generation.

Research and Education

Our laboratory directs Japanese Society for Bioinformatics (JSBi) as a board member and leads “Japanese Society for Stem-Cell Informatics”, thus students are encouraged to give a few presentations in a year. Our laboratory has a new system; the wet group conducts demonstration experiments to verify theories, which is uncommon for informatics laboratories. Therefore, students may take a part in either wet or dry group and perform researches. The wet group develops advanced single-cell analysis technologies, measuring omics data from whole human cell types. With the obtained data, the dry group constructs a human cell database (SHOGoiN), developing algorithms and tools to analyze it. Both groups collaborate to challenge the birth mechanisms of cell types or diseased cells.
As educational activities, we have a meeting for journal news and research seminar once a week to polish up speed-reading and presentation skills. From this fiscal year, we started a student exchange program with Berlin-Brandenburg Center for Regenerative Therapies, and enthusiastic students may be allowed to stay in a couple of months even if they are in the first year. Importantly, we have options to hire students in our laboratory to support his or her school expenses.

1) Database for human cell information for cell studies and differentiation analyses

2) Photo of laboratory members

Recent Publications

  1. Ying Chen, Kunie Sakurai, Sumihiro Maeda, Tohru Masui, Hideyuki Okano, Johannes Dewender, Stefanie Seltmann, Andreas Kurtz, Hiroshi Masuya, Yukio Nakamura, Michael Sheldon, Juliane Schneider, Glyn N. Stacey, Yulia Panina, Wataru Fujibuchi.
    Integrated Collection of Stem Cell Bank Data, a Data Portal for StandardizedStem Cell Information
    Stem Cell Reports 16:1-9, 2021
  2. Yulia Panina, Junko Yamane, Kenta Kobayashi, Hideko Sone, Wataru Fujibuchi.
    Human ES and iPS Cells Display Less Drug Resistance Than Differentiated Cells, and Naïve-State Induction Further Decreases Drug Resistance
    The Journal of Toxicological Sciences 46(3):131-142, 2021
  3. Tomoya Mori, Haruka Takaoka, Junko Yamane, Cantas Alev, Wataru Fujibuchi.
    Novel computational model of gastrula morphogenesis to identify spatial discriminator genes by self-organizing map (SOM) clustering
    Scientific Reports 9, Article number:12597, 2019
  4. Sakurai K, Kurtz A, Stacey G, Sheldon M, and Fujibuchi W.
    First Proposal of Minimum Information About a Cellular Assay for Regenerative Medicine.
    Stem Cells Transl. Med. 5(10):1345-1361, 2016
  5. Yamane J, Aburatani S, Imanishi S, Akanuma H, Nagano R, Kato T, Sone H, Ohsako S and Fujibuchi W.
    Prediction of developmental chemical toxicity based on gene networks of human embryonic stem cells.
    Nucleic Acids Res. 44(12):5515-5528, 2016

Theoretical Cell Science

Professor: Wataru Fujibuchi
Researcher: Junko Yamane