Human Brain Research Center

Tadashi Isa, M.D., Ph.D.
Director (concurrent service) btn

Human Brain Research Center (HBRC) conducts researches on non-invasive brain imaging and stimulation to investigate brain structures, functions and its recovery by novel methodology. A human 7 Tesla MRI system, installed less than 100 in the world and 5 in Japan, has been installed here in addition to a MEG system. We are developing new rehabilitative approaches to induce brain plasticity and improve dysfunctions more efficiently by combining brain stimulation and rehabilitative tasks. We are exploring human brain structures, functions and recovery of disabled function by cutting edge techniques.

Research and Education

The human brain comprises the largest and most developed system among animal species. Brain research should be done in a comprehensive and integrative way based on heterarchy (dynamic networking activities), not only in a reductionistic way based on hierarchy.
We focus on basic brain functions, pathophysiology and functional recovery in neurological and psychiatric disorders by using 7-T MRI, MEG and high-resolutional EEG for evaluation, and transcranial magnetic stimulation (TMS), direct current stimulation (tDCS) and static magnetic stimulation (tSMS) for treatment. Our aim is to contribute to clinical medicine and welfare of patients. We carry out education of the graduate school by collaborating with various medical departments related to neuropsychiatric diseases, regardless of whether it is in or out of the university.


Brain imaging: We conduct non-invasive neuroimaging studies from basics to clinical applications, including usage of a 7T-MRI system.

Regenerative systems neuroscience:  We conduct studies on recovery from brain dysfunction and disability by using hybrid rehabilitation techniques with non-invasive brain stimulation.

Recent Publications

  1. Okada T, Nanga RPR, Reddy R, Fujimoto K, Akasaka T, Thuy DHD, Kuribayashi H, Urushibata Y, Isa T (in submission) Hippocampal concentration of glutamate: A comparative study of glutamate CEST imaging and 1HMRS measurements at 7T.
  2. Okada T, Kuribayashi H, Kaiser LG, Urushibata Y, Salibi N, Seethamraju RT, Ahn S, Thuy DHD, Fujimoto K, Isa T (2020) Repeatability of proton magnetic resonance spectroscopy of the brain at 7 T: effect of scan time on semi-localized by adiabatic selective refocusing and short-echo time stimulated echo acquisition mode scans and their comparison. Quant Imaging Med Surg. Doi:10.21037/qims-20-517.
  3. Yokota Y, Okada T, Fushimi Y, Yamamoto A, Nakajima S, Fujimoto K, Oshima S, Koerzdoerfer G, Nittka M, Pfeuffer J, Togashi K (2020) Acceleration of 2D-MR fingerprinting by reducing the number of echoes with increased in-plane resolution: a volunteer study. MAGMA. Doi: 10.1007/s10334-020-00842-8.
  4. Koganemaru S, Mikami Y, Matsuhashi M, Truong DQ, Bikson M, Kansaku K, Mima T. (2020) Cerebellar transcranial alternating current stimulation modulates human gait rhythm. Neurosci Res. 156:265-270. doi: 10.1016/j.neures.2019.12.003.
  5. Koganemaru S, Kitatani R, Fukushima-Maeda A, Mikami Y, Okita Y, Matsuhashi M, Ohata K, Kansaku K, Mima T. (2019) Gait-Synchronized Rhythmic Brain Stimulation Improves Poststroke Gait Disturbance: A Pilot Study. Stroke. 50(11):3205-3212. doi: 0.1161/STROKEAHA.119.025354.

Human Brain Research Center

Director: Tadashi Isa, M.D., Ph.D.
Professor: Hirotaka Onoe, PhD.
Associate Professor: Tomohisa Okada, M.D., Ph.D.
Associate Professor: Satoko Koganemaru, M.D., Ph.D.
Assistant Professor: Thai Akasaka, M.D., Ph.D.
Assistant Professor: Atsushi Shima, M.D.
Research Associate: Dinh Ha Duy Thuy, M.D., Ph.D.
Research Associate: Liao Yen-Peng, Ph.D.
Research Associate: Shinichi Urayama, Ph.D.
Phone: +81-75-751-3695
FAX: +81-75-751-3202