Cardiovascular Surgery

Kenji Minatoya, M.D., Ph.D. Professor btn

We provide evidence-based standardized surgical treatments for patients with various acquired (valvular / coronary / cardiomyopathy / arrhythmia) and congenital heart diseases, and vascular diseases (aortic / peripheral). We also deal with advanced surgical care including endovascular repair for aortic aneurysms, transcatheter aortic valve implantation and ventricular assist devices for severe heart failure. We pursue cardiac and vascular regenerative researches under broad collaborations with institutes nationwide ranging from basic to clinical researches, and translational researches to pioneer the frontier of cardiovascular surgical treatments.

Research and Education

Research: We study surgical treatments for cases in which conventional surgery has been ineffective. Our research theme includes cardiac regeneration using human iPS cell-derived cardiac tissue sheets, prevention of complications related to cardiopulmonary bypass, development of surgical devices, phenotype control of vascular grafts using microRNAs, and development of decellularized vascular xenograft. We are preparing a clinical study of cardiac regenerative therapy for severe heart failure using human iPS cell-derived cardiac tissue as translational research. We also conduct observational studies from a registry database of patients undergone cardiovascular surgery from our affiliated institutes nationwide.
Education: We focus on medical students’ education and the training of trainees who are the future of cardiovascular surgery. In particular, we emphasize the development of communication skills, which are essential for cardiovascular surgeons. We provide trainees with operator opportunities while they perform their roles in the team as a team player. We use periodic questionnaires to assess the trainees’ training and achievement level. They rotated in our affiliated institutes according to their skills .


Figure 1
Members of the department

Figure 2
A: Thick viable (5-layered) human iPS cell-derived cardiac tissue sheets transplanted onto the heart of a porcine myocardial infarction model.
B: Rat cardiopulmonary bypass model.


Recent Publications

  1. Osada H, Ho WJ, Yamashita H, Yamazaki K, Ikeda T, Minatoya K, Masumoto H. Novel device prototyping for endoscopic cell sheet transplantation using a three-dimensional printed simulator. Regen Ther. 2020;15:258-264.
  2. Minatoya K, Inoue Y, Sasaki H, Tanaka H, Seike Y, Oda T, Omura A, Iba Y, Ogino H, Kobayashi J. Total arch replacement using a 4-branched graft with antegrade cerebral perfusion. J Thorac Cardiovasc Surg. 2019;157:1370-1378.
  3. Nishio H, Masumoto H, Sakamoto K, Yamazaki K, Ikeda T, Minatoya K. MicroRNA-145-loaded poly(lactic-co- glycolic acid) nanoparticles attenuate venous intimal hyperplasia in a rabbit model. J Thorac Cardiovasc Surg. 
 2019;157(6):2242-2251.
  4. Ishigami M, Masumoto H, Ikuno T, Aoki T, Kawatou M, Minakata K, Ikeda T, Sakata R, Yamashita JK, 
Minatoya K. Human iPS cell-derived cardiac tissue sheets for functional restoration of infarcted porcine 
hearts. PLoS One. 2018;13:e0201650.
  5. Kawatou M, Masumoto H, Fukushima H, Morinaga G, Sakata R, Ashihara T, Yamashita JK. Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue. Nat Commun. 2017;8:1078.

Cardiovascular Surgery

Professor: Kenji Minatoya
Associate Professor: Tadashi Ikeda
Senior Lecturer: Kazuhiro Yamazaki
Assistant Professor: Hideo Kanemitsu
Specially-appointed Assistant Professor: Hidetoshi Masumoto
Assistant Professor: Masahide Kawatou
Institute for Advancement of Clinical and Translational Science (iACT) Specific hospital Assistant Professor: Takahide Takeda
Specific hospital Assistant Professor: Yujiro Ide, Motoyuki Kumagai, Jiro Sakai
Tel: +81-75-751-3780 or 3784
FAX: +81-75-751-3098
e-mail: cvs@kuhp.kyoto-u.ac.jp
URL: http://kyoto-cvs.jp/english/