Gynecology and Obstetrics

Masaki Mandai, M.D., Ph.D. Professor btn

In the clinical field of obstetrics and gynecology, we manage physiological and psychological problems during the entire women’s life. In addition, obstetricians and gynecologists manage specialized field of pathophysiology; i.e. pregnancy and disease of female pelvic organs. In our department of gynecology and obstetrics, all postgraduate residents can learn characteristics of female pathophysiology, and can acquire basic knowledge about primary care in obstetric and gynecological emergency. In the research field, obstetrics and gynecology contain various research issues such as perinatology, gynelocogical oncology and reproductive pathophysiology.

Research and Education

Our department has four clinical/research (oncology, perinatology, reproduction medicine, health care). In oncology unit, we promote to perform minimally invasive surgery (laparoscopic and robotic) for all gynecologic disease. By omics analysis, we elucidate the tumor immunosuppressive mechanism, and investigate new tool of cancer-health care including dietary interventions in gynecologic malignancies. The perinatal lab aims to develop regenerative medicine for placental function, elucidate the mechanisms of amniotic membrane repair, develop treatments for obstetric crisis hemorrhage and premature rupture of membranes, and develop kits to predict preterm birth. In reproduction unit, we perform immunotherapy using autologous PBMC for recurrent implantation failure, PGT-A, and oncofertility therapy for child and AYA patients. We clarify the mechanism of embryo implantation, development of immature oocyte.
In health care unit, we are developing an evidence-based smartphone application for self-rating of menstruation-associated symptoms which enables appropriate diagnosis for premenstrual disorders. We also perform fMRI study to investigate the mechanism of emotional symptoms relating to menstruation.

Recent Publications

  1. Mana Taki, Kaoru Abiko, Masayo Ukita, Ryusuke Murakami, Koji Yamanoi, Ken Yamaguchi, Junzo Hamanishi, Tsukasa Baba, Noriomi Matsumura and Masaki Mandai. Tumor Immune Microenvironment during Epithelial-Mesenchymal Transition. Clin Can Res. In press.
  2. Yamanoi K, Baba T, Abiko K, Hamanishi J, Yamaguchi K, Murakami R, Taki M, Hosoe Y, Murphy SK, Konishi I, Mandai M, Matsumura N. Acquisition of a side population fraction augments malignant phenotype in ovarian cancer. Sci Rep. 2019 Oct 2;9(1):14215.
  3. Takai H, Kondoh E, Mogami H, Kawasaki K, Chigusa Y, Sato M, Kawamura Y, Murakami R, Matsumura N, Konishi I, Mandai M. Placental sonic hedgehog pathway regulates foetal growth via insulin-like growth factor axis in preeclampsia. J Clin Endocrinol Metab. 2019 May 23:jc.2019-00335.
  4. Kawasaki K, Kondoh E, Chigusa Y, Kawamura Y, Mogami H, Takeda S, Horie A, Baba T, Matsumura N, Mandai M, Konishi I. Metabolomic Profiles of Placenta in Preeclampsia. Hypertension. 2019 Mar;73(3):671-679.
  5. Ueda M, Sato Y, Horie A, Tani H, Miyazaki Y, Okunomiya A, Matsumoto H, Hamanishi J, Kondoh E, Mandai M. Endovascular trophoblast expresses CD59 to evade complement-dependent cytotoxicity. Mol Cell Endocrinol. 2019 Jun 15;490:57-67.

Gynecology and Obstetrics

Professor : Masaki Mandai
Associate professor : Eiji Kondoh
Junior Associate professor : Junzo Hamanishi, Akihito Horie, Ken Yamaguchi
Assistant professor : Haruta Mogami, Yoshitsugu Chigusa, Miho Egawa, Koji Yamanoi, , Mana Taki, Kentaro Sekiyama, Ayaka Yamaguchi, Masumi Sunada, Masayo Ukita, Asuka Okunomiya, Yusuke Sagae, Yosuke Kawamura.
TEL: +81-75-751-3269
FAX: +81-75-761-3967
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