In our division, we are practicing multi-modality treatments consisting of surgical operation and others for patients with hepato-biliary and pancreatic malignancies. We are undertaking extension of surgical indication based on the latest outcomes of clinical studies. Our practice includes minimally invasive surgery such as laparoscopic cholecystectomy, laparoscopic splenectomy, laparoscopic hepatectomy, and laparoscopic-robotic pancreatectomy for benign and malignant diseases. Our experience includes one of the largest series of living-donor liver transplantation (LDLT). It is our goal to produce leading surgeons through cutting edge researches and intensive training of surgical skills.
Research and EducationStudies on development of molecular-targeted therapy against hepatocellular carcinoma, mechanism of chemotherapy-induced liver injury, and molecular mechanism of liver fibrosis are conducted. We execute experiments for differentiation and cell transplantation of several kinds of stem/progenitor cells such as ES cells, iPS cells, hepatic stem cells, and hepatic progenitor cells. We focus on the identification and characterization of cancer stem cells of liver and pancreatic cancer. To improve clinical outcome of pancreatic cancer, we are actively undertaking the international collaborative study on precursors to pancreatic cancer or PanIN. We have islet transplantation program both in clinical practice and basic research. Development of “chimeric liver”, mesenchymal stem cell transplantation with liver transplantation, development of novel strategy/algorithm for intensive portal venous pressure, and development of a novel perfusion preservation of liver grafts by “machine perfusion” are investigated. We support graduate students not only to laboratory research, but also to learn advanced medicine and to study abroad. Conferring the degree, they can play active parts in education, research and clinic.
(Figure) Liver regeneration using decellularized liver scaffold
Macroscopic observation and histological analysis of the engineered liver graft recellularized with primary rat hepatocytes and endothelial cells. Arrowheads indicate endothelial cells attached on the vascular lumen in the decellularized liver scaffold. (Am J Transplant. 2018 in press)
- Preoperative platelet count is associated with increased risk of posthepatectomy grade A liver failure in right lobe donors for liver transplantation. Yoshino K, Taura K, Ikeno Y, Okuda Y, Nishio T, Yamamoto G, Seo S, Yagi S, Hata K, Kaido T, Okajima H, Uemoto S. Liver Transpl. 2018 Apr 20. doi: 10.1002/lt.25181.
- CAAT/enhancer binding protein-homologous protein deficiency attenuates liver ischemia/reperfusion injury in mice. Wada S, Hatano E, Yoh T, Nakamura N, Okuda Y, Okuno M, Kasai Y, Iwaisako K, Seo S, Taura K, Uemoto S. Liver Transpl. 2018 May;24(5):645-654. doi: 10.1002/lt.25053. Epub 2018 Apr 16.
- Establishment of practical recellularized liver graft for blood perfusion using primary rat hepatocytes and liver sinusoidal endothelial cells. Kojima H, Yasuchika K, Fukumitsu K, Ishii T, Ogiso S, Miyauchi Y, Yamaoka R, Kawai T, Katayama H, Yoshitoshi-Uebayashi EY, Kita S, Yasuda K, Sasaki N, Komori J, Uemoto S. Am J Transplant. 2018 Jan 16. doi: 10.1111/ajt.14666. [Epub ahead of print]
- A High Portal Venous Pressure Gradient Increases Gut-Related Bacteremia and Consequent Early Mortality After Living Donor Liver Transplantation. Yao S, Yagi S, Uozumi R, Iida T, Nagao M, Okamura Y, Anazawa T, Okajima H, Kaido T, Uemoto S.
- A Prospective Study of Intensity-modified Radiation Therapy in Comparison with Conventional 3D-RT for BR Pancreatic Cancer Patients with Arterial Involvement. Masui T, Takaori K, Anazawa T, Sato A, Nakano K, Uchida Y, Yogo A, Goto Y, Matsumoto S, Kodama Y, Kanai M, Isoda H, Mizumoto M, Kawaguchi Y, Shibuya K, Itasaka S, Uemoto S. Anticancer Res. 2017 Dec;37(12):7023-7030.
Hepato- Biliary-Pancreatic Surgery and TransplantationAssociate Professor ： Kyoichi Takaori・Toshimi Kaido・Kojiro Taura
Senior Lecturer：Toshihiko Masui・Shintaro Yagi
Assistant Professor：Koichiro Hata・Satoru Seo・Naoko Kamo・Takashi Ito
Takamichi Ishii・Ken Fukumitsu・Kazuyuki Nagai・Takayuki Anazawa・Satoshi Ogiso