Kazutaka Obama, M.D., Ph.D. Professor
Our division performs highly precise minimally invasive surgery for gastrointestinal cancers, as well as benign diseases such as morbid obesity. To practice surgery that is truly beneficial to patients, we emphasize the process of resolving clinical questions scientifically, and plan and promote many clinical research projects. We also conduct basic research on the elucidation of the pathogenesis of gastrointestinal cancers and the development of new treatments, new medical technologies and surgical education systems. Through these research and clinical activities, we educate and train young surgeons with a broad perspective.
Research and EducationMajor research interests are as follows; 1) molecular biological analysis of gastrointestinal carcinomas including stem cell biology, 2) physiological assessment of postoperative gastrointestinal function, 3) development of new imaging system to unveil and understand more detailed surgical anatomy, 4) development of novel surgical procedures and surgical instruments, 5) active involvement in the multi-institutional clinical trials to evaluate outcome of the surgical treatments.
Endoscopic operations have provided the clear, magnified view even in the narrowest of the human body space and contributed to disclose the surgical anatomy. The precise recognition of surgical anatomy is absolutely mandatory to perform radical operations for cancers, avoiding neural damages and preserving functions. In addition, firm basic research will provide a scientific rationale for surgical therapy. A new surgical therapy must be further evaluated in well-designed clinical studies.
It is critical for surgical trainees to study surgical science as well as to obtain a good surgical skill. We are confident that our program provides both of these in the finest quality.
- Kiyasu Y, Kawada K, Hirai H, et al. Disruption of CCR1-mediated myeloid cell accumulation suppresses colorectal cancer progression in mice. Cancer Lett. 2020;487:53-62.
- Ogawa R, Yamamoto T, Hirai H, et al. Loss of SMAD4 promotes colorectal cancer progression by recruiting tumor-associated neutrophils via the CXCL1/8-CXCR2 axis. Clin Cancer Res. 2019;25(9):2887-2899.
- Okada T, Hasegawa S, Nakamura T, et al. Precise three-dimensional morphology of the male anterior anorectum reconstructed from large serial histologic sections: A cadaveric study. Dis Colon Rectum. 2019;62(10):1238-1247.
- Murakami K, Obama K, Tsunoda S, et al. Linear or circular stapler? A propensity score-matched, multicenter analysis of intracorporeal esophagojejunostomy following totally laparoscopic total gastrectomy. Surg Endosc. 2020;34(12):5265-5273.
- Fujita Y, Nishigori T, Kadokawa Y, et al. Comparative outcomes of laparoscopic gastrectomy and open gastrectomy for scirrhous gastric cancer: a multicenter retrospective cohort study. Ann Surg Open, in press.
Gastrointestinal SurgeryProfessor: Kazutaka Obama
Associate Professor: Kenji Kawada
Senior Lecturer: Shigeru Tsunoda, Koya Hida
Assistant Professor: Shigeo Hisamori, Yoshiro Itatani, Tatsuto Nishigori, Tomoaki Okada, Ryosuke Okamura