Clinical Laboratory Medicine

Miki Nagao, M.D., Ph.D., Professor

Emerging and re-emerging infectious diseases and increasing drug resistance in various pathogenic microorganisms have created a worldwide interest in infectious diseases. Our aims are to develop novel diagnostic methodologies and to identify clinical evidence that will lead to more efficient management of infectious diseases. Our mission is to develop young, promising clinicians and investigators who will take an active part internationally in the fields of clinical infectious diseases, infection epidemiology, and clinical microbiology.

Research and Education

Infection is caused by a variety of pathogens from a virion to a multicellular parasite, while infected hosts show a range of immunological status from completely healthy to severely immunocompromised. Many modalities such as microscopical examination, culturing, direct detection of antigens or genomes, are now available for the identification of causative pathogens leading to the initiation of optimal treatment. However, the correct cause cannot always be accurately identified, so that there is a growing need for the development and practical application of new technologies. To meet this need, we are cooperating with the clinical laboratory of Kyoto University Hospital and with many industries for the development and practical use of novel diagnostic methods for infectious diseases.
Unfortunately, the resources for adequate education in and management of infectious diseases in Japan have been insufficient compared with those available in other developed countries. To improve this situation, scientific rationality, rather than unsubstantiated “authoritative” comments, must take priority for better practice with regard to infectious diseases. At Kyoto University Hospital, we have been providing a sophisticated consultation service regarding efficient diagnostic procedures and appropriate management of patients with severe infection, which has resulted in a steady improvement of the prognosis for patients with nosocomial sepsis. In addition, we are educating both medical students and residents in the management of patients with infectious diseases on the basis of up-to-date clinical evidence.

Time-scaled phylogeny of multi-drug resistant Escherichia coli ST131 genomes

Diagnostic performance of SARS-CoV-2 detection assays

Recent Publications

  1. Nakano S, Fujisawa T, Ito Y, Chang B, Matsumura Y, Yamamoto M, Suga S, Ohnishi M, Nagao M. Nationwide surveillance of paediatric invasive and non-invasive pneumococcal disease in Japan after the introduction of the 13-valent conjugated vaccine, 2015–2017. Vaccine. 2020;38:1818-1824.
  2. Matsumura, Y., Tsuchido, Y., Yamamoto, M., Nakano, S., Nagao, M. Development of a fully automated PCR assay for the detection of Pneumocystis jirovecii using the GENECUBE system. Medical mycology. 2019;57:841-847.
  3. Noguchi, T., Matsumura, Y., Kanahashi, T., Tanaka, M., Tsuchido, Y., Matsumura, T., Nakano, S., Yamamoto, M., Nagao, M., Ichiyama, S. Role of TEM-1 -Lactamase in the Predominance of Ampicillin-Sulbactam-Nonsusceptible Escherichia coli in Japan. Antimicrobial Agents and Chemotherapy. 2019;63:e02366-18.
  4. Yamamoto, M., Matsumura, Y., Gomi, R., Matsuda, T., Nakano, S., Nagao, M., Tanaka, M., Ichiyama, S. Molecular analysis of a blaIMP-1-Harboring class 3 integron in multidrug-resistant Pseudomonas fulva. Antimicrobial Agents and Chemotherapy. 2018;62:e00701-18.
  5. Nagao, M., Yamamoto, M., Matsumura, Y., Yokota, I., Takakura, S., Teramukai, S., Ichiyama, S. Complete adherence to evidence-based quality-of-care indicators for Staphylococcus aureus bacteremia resulted in better prognosis. Infection. 2017;45;83-91.

Clinical Laboratory Medicine

Professor : Miki Nagao
Associate Professor : Yasufumi Matsumura
Senior Lecturer : Takefumi Hitomi, Masaki Yamamoto
Assistant Professor : Yasuyuki Arai, Eri Kato, Taro Noguchi, Tomoyasu Jo, Yasuhiro Tsuchido, Satomi Yukawa
TEL : +81-75-751-3502
FAX : +81-75-751-3233