Radiation Oncology and Image-Applied Therapy

溝脇先生 Takashi Mizowaki, M.D., Ph.D. Professor btn

We are developing innovative radiotherapy technology to eradicate cancers. In molecular biological research, we are investigating causes for radioresistances and developing methods to overcome them through the analyses of DNA, RNA, proteins, etc. in experimental samples and clinical human cancer samples. In physical engineering research, we are driving forward high-precision radiotherapy such as intensity-modulated radiotherapy(IMRT), stereotactic radiotherapy and four-dimensional radiotherapy. We welcome the participation of physicians, biologists, and physical engineers who are interested in these translational approaches for cancer therapy.

Research and Education

■ Biological approach

We are promoting a wide range of basic research. Specifically, development of new radiosensitizers, omics analysis of genomes, modeling of cell dynamics after irradiation with deep learning. We collaborate with the Laboratory of Cancer Cell Biology of Kyoto University for research of mechanism of cancer cells in the field of microbiology and the Institute for Integrated Radiation and Nuclear Science for basic research of boron neutron capture therapy (BNCT).

■ Physical engineering approach

We are developing high-precision radiotherapy and innovative beam delivery technique including dynamic tumor-tracking and Dynamic WaveArc irradiation as well as their treatment plans and quality control. Our final goal is to perform personalized radiotherapy based on the molecular tracking radiotherapy which fuses biological approaches to physical techniques.

■ Clinical research

We aim to apply results from the radiobiological and physical researches to clinical practice. We are conducting clinical trials on multidisciplinary treatment which combines high-precision radiotherapy with surgery/chemotherapy. Systemic organs can be our target: brain, lung, breast, esophagus, pancreas, prostate, rectum, anal canal, etc.

 

Neutrophil extracellular traps (NETs, shown in green) triggered by intravascular redox imbalance entrap circulating tumor cells (shown in red) at the lungs and promote pulmonary metastasis.

r-042-2

Dynamic tracking irradiation with (Vero4DRT) high precision image-guided radiation therapy device, which was developed in conjunction


Recent Publications

  1. Inoue M, Enomoto M, Yoshimura M, Mizowaki T. Pharmacological inhibition of sodium-calcium exchange activates NADPH oxidase and induces infection-independent NETotic cell death. Redox Biology, in press.
  2. Shintani T, Kishi N, Matsuo Y, Ogura M, Mitsuyoshi T, Araki N, Fujii K, Okumura S, Nakamatsu K, Kishi T, Atsuta T, Sakamoto T, Narabayashi M, Ishida Y, Sakamoto M, Fujishiro S, Katagiri T, Kim YH, Mizowaki T. Incidence and Risk Factors of Symptomatic Radiation Pneumonitis in Non-Small-Cell Lung Cancer Patients Treated with Concurrent Chemoradiotherapy and Consolidation Durvalumab. Clin Lung Cancer, in press.
  3. Iramina H, Nakamura M, Mizowaki T. Actual delivered dose calculation on intra-irradiation cone-beam computed tomography images: a phantom study. Phy Med Biol, 66, 015007, 2021.
  4. Hirashima H, Ono T, Nakamura M, Miyabe Y, Mukumoto N, Iramina H, Mizowaki T. Improvement of prediction and classification performance for gamma passing rate by using plan complexity and dosiomics features. Radiother Oncol, 153, 250-257, 2020.
  5. Nakamura A, Hiraoka M, Itasaka S, Nakamura M, Akimoto M, Ishihara Y, Mukumoto N, Goto Y, Kishi T, Yoshimura M, Matsuo Y, Yano S, Mizowaki T. Evaluation of Dynamic Tumor-tracking Intensity-modulated Radiotherapy for Locally Advanced Pancreatic Cancer. Sci Rep, 2018; 8. 17096(pp1-10).

Radiation Oncology and Image-Applied Therapy

Professor:Takashi Mizowaki
Associate Professor:Yukinori Matsuo
Senior Lecturer:Michio Yoshimura・ Katsuyuki Sakanaka
Assistant professor: Aya Nakajima・Minoru Inoue・Ryota Nakashima ・Megumi Uto
Program-Specific Assistant professor:Kiyonao Nakamura・Rihito Aizawa・Nobutaka Mukumoto・Tomohiro Ono・Hiraku Iramina・Hideaki Hirashima
TEL:+81-75-751-3417
FAX:+81-75-771-9749
e-mail:radonc+ku@kuhp.kyoto-u.ac.jp
URL:http://radiotherapy.kuhp.kyoto-u.ac.jp