Professor Junko Takita
The most important thing in the Pediatrics is “development”. A number of pediatric diseases are derived from the disorders during developmental process. Therefore, investigations on them should lead to the exploitation of new diagnosis and treatment for intractable diseases. By imposing close relationship between clinic and laboratory on our research, we would like to apply our outcomes obtained from clinic and laboratory to children with intractable diseases.
Research and EducationAs a clinical department, further developing translational research is the most important mission in order to provide optimized and high-quality medicine for patients. Therefore, to elucidate molecular mechanisms and develop new therapeutic strategies of intractable pediatric diseases, we currently perform multi-omics analysis using genetic and epigenetic approaches. In addition, we also apply human iPS cell technology to get a better understanding of etiologies of congenital diseases and establish regenerative medicine for patients with intractable diseases. Our research projects are aiming to contribute to the development of pediatric research as well as life science. We will continue to foster and inspire excellent physician scientists who devote their professional effort seeking new knowledge about basic research to care patients.
- Tanaka K, Kato I, Tanaka M, Morita D, Matsuda K, Takahashi Y, Nakahata T, Umeda K, Hiramatsu H, Adachi S, Takita J, Nakazawa Y. Direct Delivery of piggyBac CD19 CAR T Cells Has Potent Anti-tumor Activity against ALL Cells in CNS in a Xenograft Mouse Model. Mol Ther Oncolytics. 2020 May 26;18:37-46. doi: 10.1016/j.omto.2020.05.013. eCollection 2020 Sep 25. PMID: 32637579
- Hanaoka S, Iwanaga K, Tomotaki S, Niwa F, Takita J, Kawai M. Antenatal corticosteroids for threatened labour facilitate thyroid maturation among preterm neonates. Clin Endocrinol (Oxf). 2020 Jun 26. doi: 10.1111/cen.14272. Online ahead of print.PMID: 32589812
- Yoshida T, Jonouchi T, Osafune K, Takita J, Sakurai H. A Liver Model of Infantile-Onset Pompe Disease Using Patient-Specific Induced Pluripotent Stem Cells. Front Cell Dev Biol. 2019 Nov 29;7:316. doi: 10.3389/fcell.2019.00316. eCollection 2019.PMID: 31850350
- Shiba T, Tanaka T, Ida H, Watanabe M, Nakaseko H, Osawa M, Shibata H, Izawa K, Yasumi T, Kawasaki Y, Saito MK, Takita J, Heike T, Nishikomori R. Functional evaluation of the pathological significance of MEFV variants using induced pluripotent stem cell-derived macrophages. J Allergy Clin Immunol. 2019 Nov;144(5):1438-1441.e12. doi: 10.1016/j.jaci.2019.07.039. Epub 2019 Sep 18. No abstract available. PMID: 31542286
- Yoshinaga D, Baba S, Makiyama T, Shibata H, Hirata T, Akagi K, Matsuda K, Kohjitani H, Wuriyanghai Y, Umeda K, Yamamoto Y, Conklin BR, Horie M, Takita J, Heike T. Phenotype-Based High-Throughput Classification of Long QT Syndrome Subtypes Using Human Induced Pluripotent Stem Cells. Stem Cell Reports. 2019 Aug 13;13(2):394-404. doi: 10.1016/j.stemcr.2019.06.007. Epub 2019 Aug 1.PMID: 31378668
PediatricsProfessor: Junko Takita
Associate Professor: Masahiko Kawai, Takahiro Yasumi
Senioir Lecture: Hidefumi Hiramatsu, Katsutsugu Umeda
Assistant Professor:Siro Baba, Takuya Hirata, Atsushi Yokoyama, Kazushi Izawa, Kogoro Iwanaga, Itaru Kato, Takeshi Yoshida, Satoshi Saida,Seiichi Tomotaki