Diabetes, Endocrinology and Nutrition

Nobuya Inagaki, M.D., Ph.D. btn

The Department of Diabetes, Endocrinology and Nutrition contributes to the advancement of diabetology, endocrinology, and nutrition science. Advanced basic research on diabetes and endocrine diseases is conducted using leading-edge technologies in order to better understand the various pathological conditions and to discover novel therapeutic approaches. We also take the initiative in promoting clinical research, epidemiological studies, and patient education for improved treatment outcomes. The nutritional approach is employed to address serious social matters such as obesity, metabolic syndrome, dementia, and frailty. Our diverse experience provides young medical doctors an opportunity to become highly trained physicians.

Research and Education

We are investigating 1) islet biology, 2) mechanism of incretin secretion from enteroendocrine cells and incretin action in various organs, 3) genetic investigation of young-onset and familial clustered diabetes, 4) novel therapeutic approaches to obesity and diabetes using brown adipose tissue, 5) generation of endocrine organs including insulin-producing cells and vascular endothelium from iPS cells, 6) non-invasive imaging of pancreatic β-cell and adrenal gland, 7) basic research for disorders in pituitary-adrenal system, thyroid gland and bone metabolism, and 8) clinical research for diabetes, obesity, endocrine diseases, and nutrition. The approach ranges from clinical to basic, and the research scale varies from pioneering small-scale study to large-scale research funded by Health and Labor Sciences Research Grant. All the teaching staffs discuss with, advice, and encourage students and instruct the practical techniques required to carry out the experiments. In addition, we work at upbringing of the experts in diabetology and endocrinology who can provide high quality treatment with a broad perspective that transcends any narrow specialization.

Ⅰ.Research projects in diabetes and metabolic disorders

Ⅱ.Research projects in endocrine disorders and clinical nutrition

Recent Publications

  1. Fujiwara Y, Yamane S, Harada N, Ikeguchi-Ogura E, Usui R, Nakamura T, Iwasaki K, Suzuki K, Yabe D, Hayashi Y, Inagaki N. Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids. Am J Physiol Gastrointest Liver Physiol. 2021 Apr 1;320(4):G617-G626. doi: 10.1152/ajpgi.00312.2020. Epub 2021 Feb 3. PMID: 33533304.
  2. Tatsuoka H, Sakamoto S, Yabe D, Kabai R, Kato U, Okumura T, Botagarova A, Tokumoto S, Usui R, Ogura M, Nagashima K, Mukai E, Fujitani Y, Watanabe A, Inagaki N. Single-Cell Transcriptome Analysis Dissects the Replicating Process of Pancreatic Beta Cells in Partial Pancreatectomy Model. iScience. 2020 Nov 6;23(12):101774. doi: 10.1016/j.isci.2020.101774. eCollection 2020 Dec 18. PMID: 33294783.
  3. Kato T, Harada N, Ikeguchi-Ogura E, Sankoda A, Hatoko T, Lu X, Yasuda T, Yamane S, Inagaki N. Gene expression of nutrient-sensing molecules in I cells of CCK reporter male mice. J Mol Endocrinol. 2021 Jan;66(1):11-22. doi: 10.1530/JME-20-0134. PMID: 33151898.
  4. Ueda Y, Hirota K, Yamauchi I, Hakata T, Yamashita T, Fujii T, Yasoda A, Inagaki N. Is C-type natriuretic peptide regulated by a feedback loop? A study on systemic and local autoregulatory effect. PLoS One. 2020 Oct 1;15(10):e0240023. doi: 10.1371/journal.pone.0240023. eCollection 2020. PMID: 33002060.
  5. Murakami T, Fujimoto H, Fujita N, Hamamatsu K, Matsumoto K, Inagaki N.  Noninvasive Evaluation of GPR119 Agonist Effects on β-Cell Mass in Diabetic Male Mice Using 111In-Exendin-4 SPECT/CT. Endocrinology. 2019 Dec 1;160(12):2959-2968. doi: 10.1210/en.2019-00556. PMID: 31613319.

Diabetes, Endocrinology and Nutrition

Professor: Nobuya Inagaki
Associate Professor: Norio Harada
Program-Specific Associate Professor: Daisuke Taura
Special Appointment Lecturer (Hospital): Junji Fujikura
Assistant professor: Yoshihito Fujita, Daisuke Tanaka, Hisahito Fujii, Masahito Ogura, Kaori Ikeda, Shunsuke Yamane, Ichiro Yamauchi, Hiroyuki Fujimoto (Radioisotope Research Center, Agency for Health, Safety and Environment, Kyoto University)
Program-Specific Assistant Professor: Hisato Tatsuoka, Yohei Ueda, Takaaki Murakami
Program-Specific Professor (Preemptive Medicine and Lifestyle. Disease Research Center): Mayumi Inoue
Program-Specific Assistant Professor (Preemptive Medicine and Lifestyle. Disease Research Center): Tomoko Kuwahara, Makiko Tatsumi, Sachiko Kawashima
TEL : +81-75-751-3560
FAX : +81-75-751-4244
e-mail : tounaiei@kuhp.kyoto-u.ac.jp
URL : http://metab-kyoto-u.jp/