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Research Projects
EBM Research Center
Translational Research Center
National Bio Resource Project
Center for Innovation in Immunoregulative Technology and Therapeutics(AK Project) 
Center for frontier Medicine (G-COE)
Kyoto Unit Center for Japan Environment & Children’s Study (JECS)
TK Project
DSK Project: Laboratory for Malignancy Control Research 
TMK project upon operation of “Laboratory for Kidney Research” 
Program for Education and Research on Science and Technology in Public Sphere Center for Promotion of Interdisciplinary Education and Research Kyoto University

>Past Reserch

EBM Collaborative Research Center

The modern clinical medicine is markedly developing based on the advances of science and technology. In the future, new medical techniques are expected to be put to practical use continuously. In this context, the importance of evidence based medicine (EBM) is well-recognized for the medical development. EBM is implemented by integrating individual clinical expertise with the best available external clinical evidence from systematic research, and is aiming the conscientious, explicit, and judicious use of current best evidence.

EBM Collaborative Research Center

The EBM Research Center at Kyoto University was established in February 2001, which is the first collaborative institution for clinical research at national universities in Japan. Its purpose is to carry out prompt and accurate scientific evaluations of diagnostic and therapeutic methods by academia-initiative clinical trials related to EBM. The center has supported in terms of execution of clinical trials along with its management by providing technical know-how of ethical consideration, study design, physicians’ collaboration, patient recruitment, data management, and bio-statistical analysis. The EBM Research Center has so far carried out more than 20 academia-initiative clinical trials and been highly-evaluated internationally. We are working for establishing the clinical evidence in Japan and transmitting it worldwide. In detail, please refer to the following our website for more information.


Director of the EBM Research Center: Professor Kazuwa Nakao



Translational Research Center
To improve outcome of treatment or prevention from incurable diseases by creation and development of novel medical treatments and diagnoses is one of the big missions given to the Kyoto University Graduate School of Medicine and to Kyoto University Hospital.  For this purpose, in April 2001, Kyoto University Hospital took a new strategy to convert the findings of basic medicine and biology efficiently into novel clinical diagnosis and treatment by establishing a center, named Translational Research Center (TRC), to promote such translational and synthetic research.
Translational Research Center


Prof. T. Uchiyama, Director of the University Hospital and Professor of Dept. Hematology and Oncology has taken the directorship of the TRC.

The TRC consists of three departments, Departments of Experimental Therapeutics (for research to discover new drugs and to develop novel methods for diagnosis and treatment: Prof. A. Shimizu), of Clinical Trial Design and Management (for designing clinical trial, and protocol development, and statistical analysis of trial results: Prof. M.Fukushima), and of Clinical Innovative Medicine (for organizing clinical trial team and conducting clinical trial: Prof. M.Yokode).


Director of the Kyoto University Hospital: Professor Takashi Uchiyama





Cell/Biodynamics Simulation Project


This project is one part of the National BioResource Projects (NBRP) in Japan for more than 20 species including animals, plants, microbes, tissues and DNAs. It is founded by the Japanese Ministry of Education, Culture, Sports, Science and Technology (Monkasho) and started in 2002. The major purpose of this project is to collect, preserve, and provide bioresources (such as experimental animals and plants) that are essential experimental materials for life sciences research. The project also aims to improve the bioresources by increasing the value of bioresources through enriching genome information and developing fundamental technologies for preservation and other necessary procedures. The Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, is the central facility for the species rat.
1. Collection, preservation and provision of rat strain information.
2. Improving bioresources by increasing the value of bioresources through enriching genome information.
3. Measuring parameters for functional characterization of deposited rat strains. 4.Quality assurance through microbial and genetic monitoring conducted with all strains.
5. Coordination of research using deposited rat strains.
6. Overseas promotion of cryopreservation and assisted reproductive technologies.
7. Exchanging information around the rat in annual Rat Resource and Research Meeting.
NBRP-Rat contributes as the world’s largest rat repository to various fields of biomedical research. A catalogue of comparable, standardized and well characterized rat strains will lead to new and more precise research topics as well as it will facilitate biomedical sciences, drug discovery and advanced chemical research not only in Japan but worldwide.
Project Manager: Takashi Kuramoto, Ph.D., Associate Professor, Institute of Laboratory Animals, Graduate School of Medicine
3rd Term: April 2012 – March 2016




Cell/Biodynamics Simulation Project

Translational Research CenterThe morbidity of patients with the allergic diseases is now reaching almost one third of the total Japanese population. It has also been reported that more than 200 million people suffered from these diseases in the advanced nations. Further, several kinds of cancer still have high mortality rates and there are many patients suffering from intractable immunological diseases including autoimmune diseases. It is evident that establishment of safe immunoregulation technologies is required for the development of organ transplantation and regenerative medicine, which are expected to be medical cures of the next generation.

Some of the critical processes for the drug development in the Japanese pharmaceutical industry still remain at a bottleneck, including discovery and identification of the novel target molecule for the drug discovery, rational drug design and synthesis, compound conversion technology, validation procedures for drug candidates in medical applications, technology to evaluate the advantages of biological drugs, and efficient translational research.

In order to overcome these fundamental issues and discover new drugs to cure above severe diseases, the Faculty of Medicine, Kyoto University is starting to develop innovative "immunoregulative drugs and technologies" by co-researching with one of the biggest Japanese pharmaceutical companies Astellas Pharma Inc. Kyoto University and Astellas will work jointly to achieve the break-through innovations in drug discovery system and innovative drugs of the next generation.

This innovation center has been adopted to the program, "Formation of Innovation Center for Fusion of Advanced Technologies," funded by the Japanese Science and Technology Agency (JST) under the Ministry of Education, Culture, Sports, Science and Technology (MEXT).


Kyoto Unit Center for Japan Environment & Children’s Study (JECS)

The Japan Environment and Children's Study (JECS), a birth cohort study, was launched in 2011 in order to evaluate the impact of various environmental factors on children's health and development. Recruiting expecting mothers for 3 years, exposure measurements and follow-up surveys begin at the early stage of pregnancy and will continue until the participating child reaches the age of 13. It is the Ministry of the Environment that conducts such a nation-wide and long-term birth cohort study involving 100,000 parent-child pairs in total across 15 regions of the nation. Kyoto Unit Center is one of the regional centers of JECS, which is supported by two research institutes; one is Kyoto University Graduate School of Medicine and School of Public Health, and the other is Center for Baby Science, Doshisha University Graduate School of Psychology. We examine growth and health condition of the children who are born in 1) Sakyo and Kita Wards in Kyoto City, 2) Kizugawa City, and 3) Nagahama City. Further information about the study is described in the URL below. We hope many pregnant women who live in these regions will take part in this significant study in order to build in the future a secure environment where children can grow up healthy and parents can raise them with confidence in safety.

Project Leader:Ikuo Konishi, M.D., Ph.D.

Director of Kyoto Unit Center & Professor of Obstetrics and Gynecology,

Kyoto University Graduate School of Medicine


Cell/Biodynamics Simulation Project

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Cell/Biodynamics Simulation Project

Cancer is probably inevitable in organisms that have flexible mechanisms in regulating development, growth, and tissue repair. Malignant behaviors of cancer cells, however, must be controllable. In this project, we focus on several promising areas of cancer research (e.g., angiogenesis, invasion, metastasis, hypoxia-response, epigenetics, alternative splicing, and bioinformatics) to elucidate the essential features and molecular bases of malignant phenotypes associated with cancer cells.  Our aim is to make the best use of such knowledge as rapidly as possible in the clinic. 

Project Leader:Prof. Makoto Noda, Graduate School of Medicine
Laboratory Chief:Prof. Hiroshi Hiai, Graduate School of Medicine

Industrial Partner: Dainippon Sumitomo Pharma Co., Ltd.

Term: April 2011 - March 2016


Cell/Biodynamics Simulation Project

Our research teams are focusing on the elucidation of the mechanisms underlying the progression of chronic kidney disease (CKD) and the discovery of the therapeutic approaches towards CKD. Due to limited understanding of its pathophysiology, the current medication globally available does not always give enough satisfaction to patient with CKD, which fails to attenuate the increase in the number of patients with end-stage renal disease. Knowing the precise biochemical and molecular mechanism(s) underlying the pathogenesis of CKD enables us to find appropriate therapeutic approaches. Thus, our research purpose and goal are to figure out how CKD starts and progresses, and to find out the way(s) to counteract or reverse the progression. To reach this goal, integrated collaboration with pharmaceutical industry is in progress upon a five-year credit.

Project Leader:Professor Motoko YANAGITA, MD.Ph.D. Graduate School of Medicine
Sub-leader:Toshiaki AKIRA, Ph.D, Professor specially appointed by Graduate School of Medicine.

Industrial Partner: Mitsubishi Tanabe Pharma Corporation and Kyoto University

Duration: 5 years (with review at 3 years)

Basic agreement on institution-level collaborative R&D signed March 11, 2011


Cell/Biodynamics Simulation Project

Japan has been promoting science and technology (S&T) for 15 years under three successive Science and Technology Basic Plans. The 4th Basic Plan also provides for the “integrated development of science, technology, and innovation (STI) policy”. In furthering the relationship of S&T to society, it is necessary to carry out STI policy, as part of policies for society and the public good, with the broad participation of citizens, gaining their understanding and trust.



Program for Education and Research on Science and Technology in Public Sphere (STiPS)

Kyoto University, with Osaka University, was selected as one of the sites for the human resource development of "SciREX: Science for RE-designing Science, Technology and Innovation Policy" by the Ministry of Education, Culture, Sports, Science, and Technology. The program aims to promote international-level research and human resource development at the graduate schools selected as the Hub Institutions for educating experts of evidence-based policy making as well as researchers who shall deepen and expand the emerging research field of "science of STI policy”.

In February 2012, a unit for “Program for Education and Research on science and Technology in Public Sphere” was set up in the Center for the Promotion of Interdisciplinary Education and Research in Kyoto University.

To establish science and technology innovation policies, it is necessary to develop evidence based policymaking not only by evidences based “quantifiable data” including the methodology of technology assessment but also process of public engagement in science and technology with deliberation “intensive debate” by various stakeholders including citizens.

Our educational program from 2013 establishes a minor specialization as a part of existing master’s programs with the aim of developing 2 types of human resource; “link” between different academic disciplines, and “link” among academics, policy and society with a focus on ethical, legal and social issues (ELSI) in science and technology.



Research for creating policies that inspire innovation and solve social issues

Conceptual diagram of the decision-making from the various regions

With regard to the research for focusing on ELSI in science and technology, graduate students will engage in important theme such as prioritization among different policy issues and optimization of allocation of limited resource.

Conceptual diagram of evidence-based innovation policy

With regard to the research for developing evidence-based innovation policy, visualization is one of the essential methodology for solve the social issues. Graduate students will also focus to the circulation of the collecting real-world data, creating database, analyzing including technology assessment, creating evidences, generating policies, and formulating hypothesis. These methods are also considered useful of various fields including energy, environment, agriculture, food products, engineering, and space science.

In order to achieve our missions, we assume that there is an urgent need to foster personnel who are capable enough to think beyond their own specialized fields, and to meet science and technology and social challenges from comprehensive and diversified perspectives. We also address to develop human resources with knowledge, sense and practical capacity to conduct activities and research on public engagement and possible career paths on completion of the program expect various research positions; government jobs; position as a policy secretary: think tank employee; university research strategist; and risk communication staff; and more.

More information is available in the link of the web page is




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