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 - Rehabilitation Sciences - Occupational Therapy
Clinical Cognitive Neuroscience
The rehabilitation has become very important in countries facing severe population aging. We aim at improving quality of life of clients with physical, psychological, cognitive or developmental limitations and are studying functional recovery for improved quality of life using various techniques in neuroscience, such as brain imaging techniques. Such an approach requires us to join multidisciplinary forces including occupational and physical therapies. We welcome young enthusiastic students interested in rehabilitation sciences regardless of their educational backgrounds.

  Motomi Toichi, Toshiko Futaki, Akira Mitani
Research and Education
Our group consists of three laboratories.
In Aging, Environment and QOL research lab, we focus on exploring issues related to older adults' cognitive functioning and activity in every day living in a variety of environments including community, long-term and institutional living situations from the perspective of consumers, family members and health care providers. We have also explored issues in aging with an intellectual disability and adaptation from cognitive neuroscientific perspectives (Fig. 1).
In Cognitive Neurophysiology lab, we aim at the clarification of neural and cognitive mechanisms that underlie clinical and behavioral problems associated with psychiatric and developmental disorders, which include schizophrenia, mood disorder, autistic disorder, Asperger’s disorder and AD/HD. Our main research technique consists of electroencephalography, event-related potentials, near-infrared spectroscopy, functional MRI as well as cognitive psychological measurements. We try to incorporate our findings into the therapeutic practice in order to establish more effective and evidence-based intervention (Figs. 2, 3).
In Neuroscience lab, we focus on a neural mechanism of functional recovery providing a neural substrate to underpin rehabilitation and try to develop novel rehabilitation strategies (neuroscience-based rehabilitation). We record magnetoencephalographic (MEG) signals from stroke patients to examine cortical reorganization corresponding to improved motor and sensory performance of the paretic limb (Fig. 4). We also investigate the plasticity of neural network underlying recovery of brain function using animal models.

Clinical Cognitive Neuroscience
Professor Toshiko Futaki,
Motomi Toichi,
Akira Mitani

Hiroshi Sakai,
Jun Matsubayashi
List for Tel,
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What do you interpret the picture relevant to “person-environment-occupation”? How do you make an approach the complexity and multiple interactions from cognitive neuroscientific perspective?
Optical imaging system using near-infrared spectroscopy.
The optical technique enables us to non-invasively measure hemodynamic changes in cerebral cortex under naturalistic conditions.
Changes of hemoglobin concentration in the prefrontal cortex.
The figure shows changes of hemoglobin variables due to cognitive processing (mathematical reasoning).
Equivalent current dipole location of motor fields during extension of the right thumb (MEG study).
Laboratory members.
Recent Publications
1. Tominaga, W., Matsubayashi, J., Deguchi, Y., Minami, C., Kinai, T., Nakamura, M., Nagamine, T., Matsuhashi, M., Mima, T., Fukuyama, H., Mitani, A. (2009) A mirror reflection of a hand modulates stimulus-induced 20-Hz activity. Neuroimage 46: 500-504.
2. Kinai, T., Matsubayashi, J., Minami, C., Tominaga, W., Nakamura, M., Nagamine, T., Matsuhashi, M., Mima, T., Fukuyama, H., Mitani, A. (2009) Modulation of stimulus-induced 20-Hz activity during lower extremity motor image. Neurosci Res 64: 335-337.
3. Sano, M., Futaki, T., Kobashi, R., Teranishi, K. (2006) Abnormal eye movement patterns on a 2-point alternate fixation task and a routes finding task in unilateral spatial neglect. Jpn. J. Occupational Therapy 25: 322-333.
4. Toichi M, Findling RL, Kubota Y, Calabrese, JR, Wiznitzer M, McNamara NK, Yamamoto K. (2004) Hemodynamic differences in the activation of the prefrontal cortex: Attention vs. higher cognitive processing. Neuropsychologia 42: 698-706.
5. Toichi M, Kamio Y, Okada T, Sakihama M, Youngstrom EA, Findling RL, Yamamoto K. (2002) A lack of self-consciousness in autism. American Journal of Psychiatry 159: 1422-1424.