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 - Laboratory Science - Information Technology and Medical Engineering
Medical Imaging System Sciences
Aiming to earlier diagnosis, improved accuracy of diagnosis and adequate treatment support, in our laboratory, we have researched advanced medical equipment. The topics being studied cover both of the fundamental research and clinical application. The former includes developing real-time and non-invasive sensing and imaging of biomedical information, which is relevant to tissue characteristics and function in addition to morphology. The latter includes applications of advanced ultrasound and optical imaging technology to diagnosis and minimally-invasive treatment support of diseases such as beast cancer, chronic hepatitis, myocardial infarction.

  Tsuyoshi Shiina, PhD(in Eng. & Med. Sci)
Research and Education
Nowadays, non-invasive imaging equipment such as CT, MRI, US is indispensable to medical care. However, diagnostic information about tissue characteristics and function is insufficient compared with morphological information. Then, there is a real need for development of advanced medical imaging modalities for earlier diagnosis and more accurate differential diagnosis. In our laboratory, using ultrasound which has the advantage of being non-invasive, real-time, many biomedical imaging technologies such as 3-D blood flow vector imaging, myocardial contractility imaging have been investigated. As for imaging of tissue characteristics, real-time tissue elasticity imaging has been developed in our laboratory and world’s first practical use of elasography for breast cancer diagnosis was achieved in collaboration with industries and university.
In recent years, we started research on novel non-invasive imaging modality which combines ultrasound and optics, in the project ‘Innovative Techno-Hub for Integrated Medical Bio-imaging’ financed by JST and MEXT.
Including this, we are now working the following research topics.
(1)Ultrasound tissue elasticity imaging
 a)Breast cancer, prostate cancer diagnosis
 b)Quantitative assessment of arteriosclerosis
 c)Staging of fibrosis and CAD for hepatic cirrhosis
(2)Myocardial contractility imaging
(3)3-D blood flow imaging
(4)Fusion technology of ultrasound and optical imaging
(5)Ubiquitous medical image diagnosis
(6)Theory for non-invasive biomedical measurement and medical imaging analysis.
Through these research works, we also aim to foster human resource to be active in wide fields from development of medical equipment to clinical practice.

Medical Imaging System Sciences
Professor Tsuyoshi Shiina

Kenichi Otsuka
Assistant Professor:Shuhui Bu
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Ultrasound tissue elasticity imaging equipment(elasography)
Elastogram of breast cancer(non-invasive ductal carcinoma )
Assessment of coronary plaque using IVUS elastography
Ubiquitous medical image diagnosis
Recent Publications
1. H. Nakagawa, S. Ueno, T. Shiina, M. Kotani, S. Kubota, "Application of radical chain reactions to drug release controlling of liposomal carriers under high magnetic fields," Journal of Applied Physics, Vol. 105, 07B323, 2009.
2. T. Shiina, M. Yoshida, M. Yamakawa, N. Nitta: “Microscopic Measurement of Three-Dimensional Distribution of Tissue Viscoelasticity,” Acoustical Imaging, pp.11-18, 2008.
3. T. Shiina: “In vitro 3-D Measurement of Tissue Viscoelasticity by Ultrasound”, Int. Journal of Appl. Biomed. Eng. Vol.1, No.1, pp.1-6,2008.
4. H. Nakagawa, T. Shiina, M. Sekino, M. Kotani, S. Ueno: “Fusion and Molecular Aspects of Liposomal Nanocarriers Incorporated with Isoprenoids,” IEEE Trans. NanoBioscience, Vol. 6, pp. 219-222, 2007.
5. A. Itoh, E. Ueno, E. Tohno, H. Kamma, H. Takahashi, T. Shiina, M. Yamakawa, T. Matsumura: “Breast Disease: Clinical Application of Ultrasound Elastography for Diagnosis,” Radiology, Vol. 231, No. 2, pp. 341-350, 2006.