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 - Laboratory Science - Medical Labolatory Science
Innovational Laboratory Medicine
The cause of diseases can be largely classified into tumor, infection, heredity, hemodynamic disorder, immune disorder, metabolic disorder, and environmental factor, while we focus our researches on tumor, heredity, and infection. Our objective is to study the nature of diseases regardless of the field of laboratory testing, and we believe the outcome will help the development of laboratory testing studies. We educate students about these causes of diseases through lectures and experiments. We coordinate with the department of clinical laboratory and the department of diagnostic pathology so that we can integrate basic and clinical medicine.

  Tetsuya Takakuwa
Research and Education
1. Analysis of the normal and abnormal morphogenesis in human embryo (Takakuwa) Congenital Anomaly Research Center stores several ten thousands of human embryo samples. To explore normal human development and find novel abnormalities and diseases, and the cause of them, by utilizing non-invasive, 3-dimensional analysis method like MR imaging and EFIC imaging.The data contribute to a better understanding of morphogens of human embryo, and serve as a useful reference for fetal medicine and prenatal diagnosis.
2.Mechanism of humoral immune response against retrovirus infection (Ibuki)
We are trying to develop an extremely sensitive ELISA for measurement of an anti-virus specific antibody against SIV or SHIV and with it, examine whether humoral immunity is related to control of the virus multiplication in the monkeys infected with SIV or SHIV.
3.Study on the mechanism of resistance against anti-HIV-1 drugs using SHIV-monkey model. (collaboration with Lab. for Viral Replication, I.V.R.) (Ibuki)
To elucidate the acquisition mechanism of drug-resistance of HIV-1 during ART (anti-retroviral therapy), we analyze the viral mutation in rhesus macaques infected with SHIV having the HIV-1 pol gene before and after ART.

Innovational Laboratory Medicine
Professor Tetsuya Takakuwa

Kentaro Ibuki
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Stage 56 Embryo MR imaging.
Virus particle and genome structure of SHIV.
Recent Publications
1. Yamada S, Takakuwa T, The Human Embryo, InTech – Open Access Publisher, Rijeka, Croatia, 2012
2. Kagurasho M, Yamada S, Takakuwa T et al, Movement of the external ear in human embryo, Head Face Med. 2012 Feb 1;8(1):2.
3. Nakashima T, Yamada S, Takakuwa T et al, Morphometric analysis of the brain vesicles during the human embryonic period by magnetic resonance microscopic imaging, Congenit Anom (Kyoto). 2012 Mar;52(1):55-8 
4. Hirose A, Yamada S, Takakuwa T et al, Embryonic liver morphology and morphometry by magnetic resonance microscopic imaging , Anat Rec (Hoboken). 2012 Jan;295(1):51-9.
5. Tsuruyama T, Maruyama Y, Kanaya K, Takakuwa T et al, MLV integration induces the formation of transcription factor complexes on palindromic sequences in the Stat5a gene during the development of pre-B lymphomagenesis, Am J Pathol. 2011;178(3):1374-86.
6. Himeno A. Akagi T. Uto T. Wang X. Baba M. Ibuki K. et al. : Evaluation of the immune response and protective effects of rhesus macaques vaccinated with biodegradable nanoparticles carrying gp120 of human immunodeficiency virus. Vaccine, 28(32): 5377-5385, 2010
7. Matsuda K. Inaba K. Fukazawa Y.Matsuyama M. Ibuki K. et al. : In vivo analysis of a new R5 tropic SHIV generated from the highly pathogenic SHIV-KS661, a derivative of SHIV-89.6. Virology, 399(1): 134-143, 2010
8. Inaba K. Fukazawa Y. Matsuda K. Himeno A. Matsuyama M. Ibuki K. et al. : Small intestine CD4+ cell reduction and enteropathy in simian/human immunodeficiency virus KS661-infected rhesus macaques in the presence of low viral load. J. Gen. Virol., 91(Pt3): 773-781, 2010