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 - Laboratory Science - Medical Laboratory Science
Applied Laboratory Science
Laboratory science aims to establish and realize concepts and methods for extracting and analyzing various information from molecular and cellular levels to the organ level, for the purpose of elucidating structure and function of livings, clarifying etiology and pathophysiology of various diseases and establishing diagnosis and treatment of diseases. In this area, we focus on structural and functional analysis indispensable for diagnosis or treatment of diseases. Accordingly, we promote studies on new concept and technology on the basis of medicine, biology and information technology. We intend to encourage new talents who will act as a leader in the fields of education, research and clinical practice.

  Akihiko Nakaizumi,
Souichi Adachi

Research and Education
【Adachi Labo】
Many hematologic malignancies of children have been cured because of progression of treatments. But, still some of these patients relapse or suffer serious complications. Our laboratory has many projects related with new treatments or diagnostic tools in these patients.
(1) Mechanism of new type of cell death induced by molecular target therapy
(2) Development of new treatments and new prognostic factors in child AML
(3) Analysis of serious complications in patients after stem cell transplantation.
【Nakaizumi Labo】
Our aim is to bring up a talented person familiar with various laboratory examinations related to pancreatobiliary malignancies. I hope that he/she will play an active role as an equal partner of gastroenterologist in the clinical setting.
Our laboratory has many projects related with new diagnostic tools or treatments in the patients with pancreatobiliary malignancies.
(1) Early diagnosis of pancreatobiliary malignancies
(2) Endoscopic diagnosis and treatments
(3) Analysis of the high risk group for pancreatic cancer and development of the medical checkup system for the early detection of pancreatic cancer
(4) Conventional or rapid cytological examinations in digestive malignancies.

Applied Laboratory Science
Professor Souichi Adachi,
Akihiko Nakaizumi

Hiroshi Itoh
List for Tel,
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Homepage Adachi Labo
Adachi's Lab
Nakaizumi's Lab
Recent Publications
1. Bando M, Iwakura H, Ariyasu H, Hosoda H, Yamada G, Hosoda K, Adachi S, Nakao K, Kangawa K, Akamizu T. Transgenic overexpression of intra-islet ghrelin does not affect insulin secretion or glucose metabolism in vivo. AJP - Endocrinology and Metabolism in press
2. Kato I, Niwa A, Heike T, Fujino H, Saito MK, Umeda K, Hiramatsu H, Ito M, Morita M, Nishinaka Y, Adachi S, Ishikawa F, Nakahata T. Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis. Plos One in press
3. Nishinaka Y, Arai T, Adachi S, Takaori-Kondo A, Yamashita K: Singlet oxygen is essential for neutrophil extracellular trap formation. Biochem Biophys Res Commun in press
4. Yamaguchi K, Kanemitsu S, Hatori T, Maguchi H, Shimizu Y, Tada M, Nakagohri T, Hanada K, Osanai M, Noda Y, Nakaizumi A, Furukawa T, Ban S, Nobukawa B, Kato Y, Tanaka M. Pancreatic ductal adenocarcinoma derived from IPMN and pancreatic ductal adenocarcinoma concomitant with IPMN. Pancreas. 2011;40:571-580.
5. Michihiro Mori, Tomoyuki Miyamoto, Hiromasa Yakushiji, Setsuyo Ohno, Yasuyuki Miyake, Takuya Sakaguchi, Manabu Hattori, Atsushi Hongo, Akihiko Nakaizumi, Masatsugu Ueda, Eiji Ohno. Effects of N-[N-(3,5-difluorophenacetyl-L-alanyl)]-Sphenylglycine t-butyl ester (DAPT) on cell proliferation and apoptosis in Ishikawa endometrial cancer cells. Human Cell 2011/12/22
6. Takahashi H, Ohigashi H, Ishikawa O, Eguchi H, Gotoh K, Yamada T, Nakaizumi A, Uehara H, Tomita Y, Nishiyama K, Yano M, Serum CA19-9 alterations during preoperative gemcitabine-based chemoradiation therapy for resectable invasive ductal carcinoma of the pancreas as an indicator for therapeutic selection and survival. Annals of surgery. 2010; 251: 461-469.