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 - Clinical Medicine (Core Departments) - Surgery for Sensory and Motor Systems
Ophthalmology and Visual Sciences
Vision is a very important function for human life. The process of vision is very complicated that requires numerous components of eye and brain work together. Our focus in research is to clarify the mechanism of various vision threatening eye diseases and to develop new therapeutic approaches for them. To harmonize the ideas from clinics with good quality research, students must tackle not only in research but also in clinical works. You are qualified to join our department if you have a desire to see the details of eye diseases.

  Nagahisa Yoshimura, M.D., Ph.D.
Professor
Research and Education
Everything related to vision is theme in our department. Vision is a very important function for human life and our interests of research is to understand underlying mechanisms of ocular diseases and the abnormalities that lead to severe visual loss. Our mission is to carry out high-grade laboratory research through observation and knowledge that can be obtained in the clinics.
Eye is a very small organ with the size of around 25mm in diameter. However, the structure and function of the eye is very complicated and many of the pathogenesis of ocular diseases has not been clarified yet. Because of the complexity, eye research requires many kinds of knowledge including not only vascular biology, neural cell biology, molecular cell biology, embryology, anatomy, genetics, but engineering, physics and electrophysiology. It is very exciting to put these knowledge and ideas together to precede eye research.
One of the main interests in our laboratory are chorioretinal diseases. On-going projects now are to figure out the detailed mechanism in the development of vascular diseases including age-related macular degeneration and diabetic retinopathy, and retinal vascular regeneration or targeted gene therapy using bone marrow progenitor cells, and an alternate approach to identifying potential therapeutic avenues to treating diseases for which there are currently no effective treatments including retinal degenerative diseases. With industrial partners, recently, we have developed new-generation optical coherence tomography (OCT) and now vigorously working to elucidate the pathophysiology of various chorioretinal diseases with the use of new-generation OCT.
It s not easy to do research and clinical work simultaneously, however, we believe that there is something important for clinicians that can be obtained only though intensive research experience. We hope you will join us and share the excitement of eye research.


Ophthalmology and Visual Sciences
Professor Nagahisa Yoshimura
Associate
 Professor


Masanori Hangai
Senior
 Lecturer


Kazuaki Miyamoto,
Akitaka Tsujikawa
Assistant
 Professor


Kenji Yamashiro,
Sotaro Ooto,
Tadamichi Akagi,
Tomoaki Murakami,
Hanako Ikeda,
Akio Oishi,
Akihito Uji,
Norimoto Goto,
Ken Ogino
TEL +81-75-751-3248
FAX +81-75-752-0933
e-mail eyemed.kyoto-u.ac.jp
URL http://www.kuhp.kyoto-u.ac.jp/~ganka/
Recent Publications
1. Nukada M, Hangai M, Mori S, Nakano N, Nakanishi H, Ohashi-Ikeda H, Nonaka A, Yoshimura N. Detection of localized retinal nerve fiber layer defects in glaucoma using enhanced spectral-domain optical coherence tomography. Ophthalmology 118: 1038-1048, 2011
2. Tomita K, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Otani A, Nakayama Y, Yoshimura N. Treatment of polypoidal choroidal vasculopathy with photodynamic therapy combined with intravitreal injections of ranibizumab. Am J Ophthalmol 153: 68-80, 2012
3. Uji A, Hangai M, Ooto S, Takayama K, Arakawa N, Imamura H, Nozato K, Yoshimura N. The source of moving particles in parafoveal capillaries detected by adaptive optics scanning laser ophthalmoscopy. Invest Ophthalmol Vis Sci. 20: 171-178, 2012
4. Nakano N, Ikeda HO, Hangai M, Muraoka Y, Toda Y, Kakizuka A, Yoshimura N. Longitudinal and simultaneous imaging of retinal ganglion cells and inner retinal layers in a mouse model of glaucoma induced by N-methyl-D-aspartate. Invest Ophthalmol Vis Sci. 52:8754-8762, 2011
retinal nerve fiber layer defects in glaucoma Ref.1
reatment of polypoidal choroidal vasculopathy with photodynamic therapy combined with intravitreal injections of ranibizumab Ref.2
parafoveal capillaries detected by adaptive optics scanning laser ophthalmoscopy. Ref.3
ganglion cells in glaucoma model mice Ref.4
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